Assessment of the precision in co-registration of structural MR images and PET images with localized binding

Abstract The aim of the present study was to access and compare the accuracy and reproducibility of two fully automatic and two manual methods for co-registration of structural T1-weighted MR images and functional images with localized binding. It is concluded that for functional images with distributed binding all over the brain, such as F18-FDG images, the automatic methods are preferable, while for images with localized binding, such as F18-Altanserin 5-HT 2A neuroreceptor images, it is essential to use methods that handle this special problem, like the proposed manual methods.

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