Effect of intravenously applied canrenoate on ampullar endolymphatic potential.

The effect of canrenoate, an aldosterone antagonist, on the ampullar endolymphatic potential (AEP) was examined to assess a possible role for aldosterone in the ampulla. Intravenous administration of canrenoate increased the AEP amplitude in a dose-dependent manner, with a significant reduction of the AEP negative component induced by anoxia. Pretreatment with aldosterone attenuated the AEP change produced by canrenoate. The results suggest that aldosterone may be involved in the modulation of ampullar function.

[1]  M. Drescher,et al.  High affinity aldosterone binding sites (Type I receptors) in the mammalian inner ear , 1993, Hearing Research.

[2]  M. Drescher,et al.  Aldosterone mediates an increase in [3H]ouabain binding at Na+, K+ -ATPase sites in the mammalian inner ear , 1993, Brain Research.

[3]  B. Rossier,et al.  Aldosterone regulation of gene transcription leading to control of ion transport. , 1992, Hypertension.

[4]  S. Komune,et al.  Ototoxic effect of potassium canrenoate on the guinea pig cochlea. , 1991, Acta oto-laryngologica.

[5]  R. O'neil.  Aldosterone regulation of sodium and potassium transport in nsport in the cortical collecting duct , 1990 .

[6]  K. Rarey,et al.  Presence of type I and type II/IB receptors for adrenocorticosteroid hormones in the inner ear , 1989, Hearing Research.

[7]  O. Oudar,et al.  Sodium transfer from endolymph through a luminal amiloride-sensitive channel. , 1989, The American journal of physiology.

[8]  W. Ward,et al.  Phenylarsine oxide inhibition of endocytosis: effects on asialofetuin internalization. , 1989, The American journal of physiology.

[9]  J. Funder,et al.  Type I receptors in parotid, colon, and pituitary are aldosterone selective in vivo. , 1987, The American journal of physiology.

[10]  R. O'neil,et al.  Effects of mineralocorticoids on transport properties of cortical collecting duct basolateral membrane. , 1986, The American journal of physiology.

[11]  D. Benos,et al.  The amiloride-sensitive sodium channel. , 1986, The American journal of physiology.

[12]  D. C. Marcus.  Characterization of potassium permeability of cochlear duct by perilymphatic perfusion of barium. , 1984, The American journal of physiology.

[13]  G. Giebisch,et al.  Intracellular microelectrode characterization of the rabbit cortical collecting duct. , 1983, The American journal of physiology.

[14]  J. Kokko,et al.  Renal target sites and the mechanism of action of aldosterone. , 1983, Mineral and electrolyte metabolism.

[15]  K. Geering,et al.  Hormonal regulation of (Na+,K+)-ATPase biosynthesis in the toad bladder. Effect of aldosterone and 3,5,3'-triiodo-L-thyronine. , 1982, The Journal of biological chemistry.

[16]  I. Edelman.  Receptors and effectors in hormone action on the kidney. , 1981, The American journal of physiology.

[17]  R. Thalmann,et al.  Effects of anoxia and ethacrynic acid upon ampullar endolymphatic potential and upon high energy phosphates in ampullar wall , 1976, The Laryngoscope.

[18]  B. M. Johnstone,et al.  Production and role of inner ear fluid , 1975, Progress in Neurobiology.

[19]  J. Funder,et al.  Glucocorticoid and mineralocorticoid receptors in gut mucosa. , 1975, Endocrinology.

[20]  U. Schmidt,et al.  Sodium- and potassium-activated ATPase. A possible target of aldosterone. , 1975, The Journal of clinical investigation.

[21]  D. Feldman,et al.  The roles of plasma binding and receptor specificity in the mineralocorticoid action of aldosterone. , 1973, Endocrinology.

[22]  R. Kimura.  XLVIII Distribution, Structure, and Function of Dark Cells in the Vestibular Labyrinth , 1969, The Annals of otology, rhinology, and laryngology.