Possible increased risk for Alzheimer's disease associated with neprilysin gene

[1]  M. Oda,et al.  Dinucleotide repeat polymorphisms in the Neprilysin gene are not associated with sporadic Alzheimer's disease , 2002, Neuroscience Letters.

[2]  T. Iwatsubo,et al.  Neprilysin Degrades Both Amyloid β Peptides 1–40 and 1–42 Most Rapidly and Efficiently among Thiorphan- and Phosphoramidon-sensitive Endopeptidases* , 2001, The Journal of Biological Chemistry.

[3]  G. Siest,et al.  Apolipoprotein E-∈A allele and Alzheimer's disease , 1993, The Lancet.

[4]  R. Ce Neprilysin content is reduced in Alzheimer brain areas. , 2001 .

[5]  P. Winship,et al.  POLYMORPHISM , 1945, Physics and Chemistry of Molecular Assemblies.

[6]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[7]  D. Comas,et al.  Joint analysis of candidate genes related to Alzheimer's disease in a Spanish population , 2003, Psychiatric genetics.

[8]  R. Brumback,et al.  A familial case of Alzheimer's disease without tau pathology may be linked with chromosome 3 markers , 1999, Human Genetics.

[9]  J. Morris,et al.  A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia , 1998, Nature Genetics.

[10]  M. Pericak-Vance,et al.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[11]  R. Tanzi,et al.  The gene defects responsible for familial Alzheimer's disease. , 1996, Neurobiology of disease.

[12]  T. Saido,et al.  Region‐specific reduction of Aβ‐degrading endopeptidase, neprilysin, in mouse hippocampus upon aging , 2002, Journal of neuroscience research.

[13]  D. Westaway,et al.  Aβ-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Aβ pathology , 2002, Neuroscience Research.

[14]  P. Mcgeer,et al.  Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of β-amyloid peptide , 2001, Neuroscience Letters.

[15]  J. Weber,et al.  Mutation of human short tandem repeats. , 1993, Human molecular genetics.

[16]  D. Selkoe,et al.  The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease , 1998 .

[17]  R. Tanzi,et al.  REVIEWThe Gene Defects Responsible for Familial Alzheimer's Disease , 1996, Neurobiology of Disease.

[18]  J. Haines,et al.  Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.

[19]  M A Pericak-Vance,et al.  Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. , 1993, Neurology.

[20]  C. Reilly Neprilysin content is reduced in Alzheimer brain areas , 2001, Journal of Neurology.

[21]  D. T. Vernier,et al.  Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. , 1990, Journal of lipid research.

[22]  N. Inestrosa,et al.  Neurotoxicity of acetylcholinesterase amyloid β‐peptide aggregates is dependent on the type of Aβ peptide and the AChE concentration present in the complexes , 1999, FEBS letters.

[23]  P. S. St George-Hyslop,et al.  Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. , 2002, Neuroscience research.

[24]  T. Saido,et al.  Metabolic Regulation of Brain Aβ by Neprilysin , 2001, Science.

[25]  R. Blesa,et al.  Apolipoprotein E4 allele frequency in Spanish Alzheimer and control cases , 1995, Neuroscience Letters.

[26]  M. Shipp,et al.  Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[27]  M. Yamada,et al.  Lack of association of neprilysin polymorphism with Alzheimer's disease and Alzheimer's disease-type neuropathological changes , 2001, Journal of neurology, neurosurgery, and psychiatry.

[28]  R. Nitsch,et al.  Aβ42-induced Increase in Neprilysin Is Associated with Prevention of Amyloid Plaque Formation in Vivo * , 2002, The Journal of Biological Chemistry.

[29]  D. Selkoe The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease. , 1998, Trends in cell biology.