Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registry

M. Giacomini | M. Antonelli | T. Welte | P. Wendel-Garcia | C. Cogliati | D. Gommers | S. Jakob | M. Jeitziner | C. Ince | S. Tharwat | S. Grazioli | J. Pugin | M. Filipovic | E. Catena | A. Ramelet | A. Carsetti | F. Roche-Campo | A. Hollinger | M. Siegemund | R. Schuepbach | V. Zotzmann | T. Wengenmayer | M. Wu | J. Bartussek | R. Nikandish | Y. Que | E. Reverter | A. Westphalen | P. Buehler | M. Elhadi | L. Salvi | Javier Fernández | P. Castro | C. Gebhard | T. Wengenmayer | A. Dullenkopf | N. Marczin | A. Magliocca | M. Brenni | P. Guerci | Jorge Gámez-Zapata | M. Biggiogero | H. T. Hashim | S. Brugger | M. Bocci | P. Schott | Peter Schott | E. Gamberini | D. Heuberger | F. Boroli | B. Seeliger | A. Moser | G. Bolondi | J. Montomoli | S. Ceruti | A. Glotta | A. Potalivo | M. Losser | T. Aslanidis | A. Ouyahia | M. Rais | U. Pietsch | E. Casarotta | M. Hilty | K. Marquardt | E. Rezoagli | A. Fogagnolo | H. Aguirre-Bermeo | S. Keiser | Tobias Hübner | I. Galal | E. Colak | J. Wiegand | P. Locher | T. Fumeaux | E. Novy | Marie-Hélène Perez | P. Bühler | M. P. Montes | K. Stahl | A. Christ | G. Kleger | T. Tschoellitsch | E. Sauras-Colón | R. Ensner | Luis A. Martínez | B. Zalba-Etayo | Paolo Giaccaglia | T. Neff | C. Schrag | M. C. Martin-Delgado | F. Turrini | N. Zellweger | S. David | R. Colombo | R. Rodríguez-García | Marco Betello | M. Abdoun | Abdulmueti Alhadi | Hind Alameen | Arowa Alansari | P. Fodor | D. Franch-Llasat | A. Korsós | S. Cereghetti | Hatem Ksouri | G. Sridharan | Jonathan Montomoli | M. Michot | H. Redecker | Isabelle Fleisch | C. Haberthuer | S. Fabbri | Antje Heise | E. Kleinert | S. Bouaoud | G. Vizmanos-Lamotte | F. M. zu Bentrup | M. Simonini | Jens Meier | M. M. Bitondo | J. Marrel | Abdurraouf Abusalama | M. Jayyab | P. Concha | A. Klarer | G. Barana | Pedro Arias-Sánchez | Pedro Arias-Sanchez | J. Apolo | G. Gangitano | Mario Alfaro-Farias | Nadine Gehring | Herminia Lozano-Gómez | B. Yuen | Anja Baltussen Weber | J. Escós-Orta | Frank Hillgaertner | Marilene Franchitti Laurent | M. Laube | M. Studhalter | C. Buerkle | Matthias P. Pedro Reto A. Jonathan Philippe Thierry Souad A Hilty Wendel-Garcia Schuepbach Montomoli | A. Caballero | Hugo Tirapé-Castro | Ibrahim Abdehaleem | G. Jurkolow | Luqman Abdulkhudhur Ahmed | Francesca Maciopinto | E. de Camillis | M. Venturi | O. Omar | Muhannud Binnawara | Ahmed Arhaym | M. Alsharif | Xiana Taboada-Fraga | A. Lander-Azcona | Angela Algaba-Calderon | Severin Urech | L. Merki | A. Lambert | Barbara Lienhardt-Nobbe | Petra Salomon | Marianne Sieber | Christian Bürkle | Peter Gerecke | Mallory Moret-Bochatay | M. Stephan | Daniela Selz | Anette Ristic | Jean-Christophe Laurent | T. Gaspert | Patrick S. Fodor | Pedro D. Wendel Garcia | Kim-Jana Fehlbier | A. Danial | Maher Almousa | Yazan Abdulbaki | Kamil Sannah | Saba Al-Ameri | P. D. W. Garcia | Michael Stephan | Mohammed Alsharif | A. Ristic | Mario Alfaro-Farias | Alberto Fogagnolo | Gian-Reto Kleger | Raquel Rodríguez-García | Herminia Lozano-Gómez | Frank Hillgaertner | Sara Cereghetti | Christian Bürkle | Julien Marrel | Marilene Franchitti Laurent | Thierry Fumeaux | P. Arias-Sanchez | Diego Franch-Llasat | Claudia Schrag | Nuria Zellweger | Gianfilippo Gangitano | Gerardo Vizmanos-Lamotte | Anja Baltussen Weber | Jesus Oscar Escos-Orta | Theodoros Aslanidis | Christian Buerkle | Stefanie Keiser | Jesús Escós-Orta | S. Al-ameri | Osama Omar | M. Perez | Govind Sridharan | Mario Alfaro-Farias | Anja Baltussen Weber | Thomas Tschoellitsch | Gian-Reto Kleger | Esther Sauras-Colón | Christian Buerkle | Theodoros Aslanidis

[1]  Miguel Ángel Martínez,et al.  Non-invasive oxygenation support in acutely hypoxemic COVID-19 patients admitted to the ICU: a multicenter observational retrospective study , 2022, Critical Care.

[2]  Stephan Luna,et al.  Increased mortality in patients with COVID-19 receiving extracorporeal respiratory support during the second wave of the pandemic , 2021, Intensive Care Medicine.

[3]  M. Antonelli,et al.  Time course of risk factors associated with mortality of 1260 critically ill patients with COVID-19 admitted to 24 Italian intensive care units , 2021, Intensive Care Medicine.

[4]  Christopher M. Horvat,et al.  Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19 , 2021, The New England journal of medicine.

[5]  J. Laffey,et al.  Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial , 2021, The Lancet Respiratory Medicine.

[6]  Miguel A Hernán,et al.  Causal analyses of existing databases: no power calculations required. , 2021, Journal of clinical epidemiology.

[7]  P. Buehler,et al.  What every intensivist should know about Tocilizumab , 2021, Critical Care.

[8]  T. V. Van Boeckel,et al.  Near real-time observation reveals increased prevalence of young patients in the ICU during the emerging third SARS-CoV-2 wave in Switzerland. , 2021, Swiss medical weekly.

[9]  T. Welte,et al.  Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort , 2021, Critical Care.

[10]  S. Hamacher,et al.  Evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months , 2021, Intensive Care Medicine.

[11]  M. Antonelli,et al.  Effect of Helmet Noninvasive Ventilation vs High-Flow Nasal Oxygen on Days Free of Respiratory Support in Patients With COVID-19 and Moderate to Severe Hypoxemic Respiratory Failure: The HENIVOT Randomized Clinical Trial. , 2021, JAMA.

[12]  Christopher M. Horvat,et al.  Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 - Preliminary report , 2021, medRxiv.

[13]  M. Hernán,et al.  BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting , 2021, The New England journal of medicine.

[14]  A. Mebazaa,et al.  Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study , 2020, Intensive Care Medicine.

[15]  T. Briggs,et al.  Patient factors and temporal trends associated with COVID-19 in-hospital mortality in England: an observational study using administrative data , 2020, The Lancet Respiratory Medicine.

[16]  Jennifer L. Bell,et al.  Effect of Hydroxychloroquine in Hospitalized Patients with COVID-19 , 2020, The New England Journal of Medicine.

[17]  Jennifer L. Bell,et al.  Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial , 2020, The Lancet.

[18]  J. Ziegel,et al.  Probabilistic analysis of COVID-19 patients’ individual length of stay in Swiss intensive care units , 2020, medRxiv.

[19]  A. Murray,et al.  Non-compliance with COVID-19-related public health measures among young adults in Switzerland: Insights from a longitudinal cohort study , 2020, Social Science & Medicine.

[20]  W. Maier,et al.  Access to intensive care in 14 European countries: a spatial analysis of intensive care need and capacity in the light of COVID-19 , 2020, Intensive Care Medicine.

[21]  M. Mckee,et al.  Comparison of Deaths Rates for COVID-19 across Europe During the First Wave of the COVID-19 Pandemic , 2020, Frontiers in Public Health.

[22]  M. Shankar-Hari,et al.  Trends in Intensive Care for Patients with COVID-19 in England, Wales, and Northern Ireland , 2020, American journal of respiratory and critical care medicine.

[23]  M. Antonelli,et al.  Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort , 2020, EClinicalMedicine.

[24]  L. Dodd,et al.  Remdesivir for the Treatment of Covid-19 — Final Report , 2020, The New England journal of medicine.

[25]  Burcu Tepekule,et al.  icumonitoring.ch: a platform for short-term forecasting of intensive care unit occupancy during the COVID-19 epidemic in Switzerland. , 2020, Swiss medical weekly.

[26]  J. Beitler,et al.  Physiologic Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome , 2019, American journal of respiratory and critical care medicine.

[27]  D. Cohen,et al.  Publisher's Note , 2017, Neuroscience & Biobehavioral Reviews.

[28]  R. Casaburi,et al.  Exercise, ageing and the lung , 2016, European Respiratory Journal.

[29]  T. Welte,et al.  Prediction of in-hospital death from community-acquired pneumonia by varying CRB-age groups , 2012, European Respiratory Journal.

[30]  Sunil J Rao,et al.  Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis , 2003 .

[31]  W. Lim,et al.  Dexamethasone in Hospitalized Patients with Covid-19 , 2021 .

[32]  Ewout W. Steyerberg,et al.  Focus on : Contemporary Methods in Biostatistics ( I ) Regression Modeling Strategies , 2017 .

[33]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .