Analysis of dialysate fluids with the use of a potentiometric electronic tongue

Abstract.This work presents the application of a potentiometric electronic tongue in non-invasive monitoring of dialysis treatment. The sensor array composed of classical ion-selective electrodes and biosensors was used for the measurements of dialysate fluids containing creatinine and urea additives at concentrations commonly present in post-dialysate fluids. The responses of sensors were processed using partial least squares method. The device was capable of determining urea and creatinine in the range of concentrations (3–12 and 0.10–0.32 mmol · L−1 for urea and creatinine, respectively). Moreover, simulated samples typical for the initial and final phase of dialysis could be differentiated.

[1]  A. Dybko,et al.  Potentiometric electronic tongue based on integrated array of microelectrodes , 2007 .

[2]  A. Machado,et al.  Array of potentiometric sensors for simultaneous analysis of urea and potassium. , 2005, Talanta.

[3]  Larisa Lvova,et al.  Chemical sensor array for multicomponent analysis of biological liquids , 1999 .

[4]  Andrew D. Ellington,et al.  Solution-based analysis of multiple analytes by a sensor array: toward the development of an electronic tongue , 1998 .

[5]  Patrycja Ciosek,et al.  Sensor arrays for liquid sensing--electronic tongue systems. , 2007, The Analyst.

[6]  D. Reinhoudt,et al.  UO2-salenes: neutral receptors for anions with a high selectivity for dihydrogen phosphate , 1992 .

[7]  Patrycja Ciosek,et al.  The analysis of sensor array data with various pattern recognition techniques , 2006 .

[8]  Zulfiqur Ali,et al.  Chemical Sensors for Electronic Nose Systems , 2005 .

[9]  Patrycja Ciosek,et al.  The Recognition of Growth Conditions and Metabolic Type of Plants by a Potentiometric Electronic Tongue , 2006 .

[10]  Dean P. Neikirk,et al.  Mimicking the mammalian sense of taste through single-component and multicomponent analyte sensors , 2002 .

[11]  Eric V Anslyn,et al.  Differential receptor arrays and assays for solution-based molecular recognition. , 2006, Chemical Society reviews.

[12]  Antonella Macagnano,et al.  Electronic nose and electronic tongue integration for improved classification of clinical and food samples , 2000 .

[13]  J B Shear,et al.  Development of multianalyte sensor arrays composed of chemically derivatized polymeric microspheres localized in micromachined cavities. , 2001, Journal of the American Chemical Society.

[14]  P. Ciosek,et al.  Polymeric membrane ion-selective and cross-sensitive electrode-based electronic tongue for qualitative analysis of beverages. , 2004, The Analyst.

[15]  R. Koncki,et al.  Bioanalytical system for control of hemodialysis treatment based on potentiometric biosensors for urea and creatinine , 2004 .

[16]  John T McDevitt,et al.  A microbead array chemical sensor using capillary-based sample introduction: toward the development of an "electronic tongue". , 2005, Biosensors & bioelectronics.

[17]  R. Hakim,et al.  Adequacy of hemodialysis. , 1992, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[18]  Zbigniew Brzozka,et al.  Classification of beverages using a reduced sensor array , 2004 .

[19]  R. Koncki,et al.  Penicillin enzyme biosensors based on pH membrane electrodes , 1996 .

[20]  Júlia M C S Magalhães,et al.  Array of potentiometric sensors for the analysis of creatinine in urine samples. , 2002, The Analyst.

[21]  Zulfiqur Ali,et al.  Data analysis for electronic nose systems , 2006 .

[22]  Francisco Céspedes,et al.  Automatic sequential injection analysis electronic tongue with integrated reference electrode for the determination of ascorbic acid, uric acid and paracetamol , 2007 .

[23]  C Di Natale,et al.  Direct and two-stage data analysis procedures based on PCA, PLS-DA and ANN for ISE-based electronic tongue-Effect of supervised feature extraction. , 2005, Talanta.

[24]  Zbigniew Brzozka,et al.  Electronic tongue for flow-through analysis of beverages , 2006 .

[25]  Salvador Alegret,et al.  Potentiometric bioelectronic tongue for the analysis of urea and alkaline ions in clinical samples. , 2007, Biosensors & bioelectronics.

[26]  T. Depner.  Prescribing Hemodialysis: A Guide to Urea Modeling , 1990 .

[27]  Eric V Anslyn,et al.  Sensing A Paradigm Shift in the Field of Molecular Recognition: From Selective to Differential Receptors. , 2001, Angewandte Chemie.