COX2 expression and Erk1/Erk2 activity mediate Cot-induced cell migration.

[1]  S. Hattori,et al.  Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Regulates Actin Organization and Cell Motility by Phosphorylating the Actin Cross-Linking Protein EPLIN , 2007, Molecular and Cellular Biology.

[2]  P. Tsichlis,et al.  Tumor Progression Locus-2 Is a Critical Regulator of Pancreatic and Lung Inflammation during Acute Pancreatitis* , 2007, Journal of Biological Chemistry.

[3]  S. Alemany,et al.  TRAF6 and Src kinase activity regulates Cot activation by IL-1. , 2006, Cellular signalling.

[4]  N. Pommery,et al.  Mechanisms leading to COX-2 expression and COX-2 induced tumorigenesis: topical therapeutic strategies targeting COX-2 expression and activity. , 2006, Anti-cancer agents in medicinal chemistry.

[5]  Steve Gerondakis,et al.  Diverse Toll-like receptors utilize Tpl2 to activate extracellular signal-regulated kinase (ERK) in hemopoietic cells. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[6]  N. Kalia,et al.  Rac1 Is Essential for Platelet Lamellipodia Formation and Aggregate Stability under Flow* , 2005, Journal of Biological Chemistry.

[7]  Amanda Y. Chan,et al.  Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion , 2005, Oncogene.

[8]  M. Backlund,et al.  Mechanisms for the Prevention of Gastrointestinal Cancer: The Role of Prostaglandin E2 , 2005, Oncology.

[9]  K. Wu Control of cyclooxygenase-2 transcriptional activation by pro-inflammatory mediators. , 2005, Prostaglandins, leukotrienes, and essential fatty acids.

[10]  C. Tsatsanis,et al.  Expression of the Tpl2/Cot oncogene in human T-cell neoplasias , 2004, Molecular Cancer.

[11]  Marshall W. Anderson,et al.  Mutational activation of the MAP3K8 protooncogene in lung cancer , 2004, Genes, chromosomes & cancer.

[12]  Y. Surh,et al.  Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. , 2004, Biochemical pharmacology.

[13]  A. Masuda,et al.  A serine/threonine kinase, Cot/Tpl2, modulates bacterial DNA-induced IL-12 production and Th cell differentiation. , 2004, The Journal of clinical investigation.

[14]  P. Cohen,et al.  15-Deoxy-Δ12,14-prostaglandin J2 Regulates Endogenous Cot MAPK Kinase Kinase 1 Activity Induced by Lipopolysaccharide* , 2003, Journal of Biological Chemistry.

[15]  S. Alemany,et al.  The COOH-Terminal Domain of Wild-Type Cot Regulates Its Stability and Kinase Specific Activity , 2003, Molecular and Cellular Biology.

[16]  C. Dumitru,et al.  Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40 , 2003, The EMBO journal.

[17]  Benjamin Geiger,et al.  How do microtubules guide migrating cells? , 2002, Nature Reviews Molecular Cell Biology.

[18]  Jeonghee Cho,et al.  Induction of COX‐2 by LPS in macrophages is regulated by Tpl2‐dependent CREB activation signals , 2002, The EMBO journal.

[19]  L. Young,et al.  The Oncogenic Protein Kinase Tpl-2/Cot Contributes to Epstein-Barr Virus-Encoded Latent Infection Membrane Protein 1-Induced NF-κB Signaling Downstream of TRAF2 , 2002, Journal of Virology.

[20]  W. Arthur,et al.  RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity. , 2001, Molecular biology of the cell.

[21]  A. Ridley Rho GTPases and cell migration. , 2001, Journal of cell science.

[22]  M. Fresno,et al.  Cot Kinase Induces Cyclooxygenase-2 Expression in T Cells through Activation of the Nuclear Factor of Activated T Cells* , 2001, The Journal of Biological Chemistry.

[23]  S. Alemany,et al.  p27kif Protein Levels and E2F Activity Are Targets of Cot Kinase During G1 Phase Progression in T Cells1 , 2001, The Journal of Immunology.

[24]  G. Kollias,et al.  TNF-α Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway , 2000, Cell.

[25]  J. Gutkind,et al.  Multiple Mitogen-Activated Protein Kinase Signaling Pathways Connect the Cot Oncoprotein to the c-junPromoter and to Cellular Transformation , 2000, Molecular and Cellular Biology.

[26]  G. Sourvinos,et al.  Overexpression of the Tpl-2/Cot oncogene in human breast cancer , 1999, Oncogene.

[27]  E. Salmon,et al.  Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblasts , 1999, Nature Cell Biology.

[28]  Alan Hall,et al.  Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement , 1999, The Journal of cell biology.

[29]  L. Johnston,et al.  TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105 , 1999, Nature.

[30]  S. Alemany,et al.  Cot Kinase Activates Tumor Necrosis Factor-α Gene Expression in a Cyclosporin A-resistant Manner* , 1998, The Journal of Biological Chemistry.

[31]  R. DuBois,et al.  Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells , 1998, Cell.

[32]  R. Walker,et al.  Modulation of myoepithelial-associated alpha6beta4 integrin in a breast cancer cell line alters invasive potential. , 1997, Experimental cell research.

[33]  S. Alemany,et al.  Cot kinase regulation of IL-2 production in Jurkat T cells. , 1997, Journal of immunology.

[34]  J. Peli,et al.  Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis. , 1996, Oncogene.

[35]  D. Pappin,et al.  Activation of MEK‐1 and SEK‐1 by Tpl‐2 proto‐oncoprotein, a novel MAP kinase kinase kinase. , 1996, The EMBO journal.

[36]  S. Aaronson,et al.  Expression cDNA cloning of a serine kinase transforming gene. , 1993, Oncogene.

[37]  P. Tsichlis,et al.  Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[38]  J. Miyoshi,et al.  Structure and transforming potential of the human cot oncogene encoding a putative protein kinase , 1991, Molecular and cellular biology.

[39]  B. Fingleton Matrix metalloproteinases: roles in cancer and metastasis. , 2006, Frontiers in bioscience : a journal and virtual library.

[40]  M. Serrano,et al.  Induction of senescence by oncogenic Ras. , 2001, Methods in enzymology.