HNPCC mutations in hMSH2 result in reduced hMSH2-hMSH6 molecular switch functions.

[1]  A. Bowcock,et al.  Genetic instability in human ovarian cancer cell lines. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[2]  R. Scott,et al.  Mutational analysis of the hMSH2 gene reveals a three base pair deletion in a family predisposed to colorectal cancer development. , 1994, Human molecular genetics.

[3]  R. Lothe,et al.  Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas. , 1995, Human Molecular Genetics.

[4]  B. Ponder,et al.  Mutation screening of MSH2 and MLH1 mRNA in hereditary non-polyposis colon cancer syndrome. , 1996, Journal of medical genetics.

[5]  P. Modrich,et al.  Mismatch repair in replication fidelity, genetic recombination, and cancer biology. , 1996, Annual review of biochemistry.

[6]  R. Kolodner,et al.  Biochemistry and genetics of eukaryotic mismatch repair. , 1996, Genes & development.

[7]  M. Schwab,et al.  Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer. , 1996, Human molecular genetics.

[8]  R. Fishel,et al.  MutS homologs in mammalian cells. , 1997, Current opinion in genetics & development.

[9]  P. Hsieh,et al.  Photocross-linking of the NH2-terminal Region of Taq MutS Protein to the Major Groove of a Heteroduplex DNA* , 1997, The Journal of Biological Chemistry.

[10]  J. Rüschoff,et al.  Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. , 1997, Cancer research.

[11]  C. Turc‐Carel,et al.  Cloning and expression analysis of a meiosis-specific MutS homolog: the human MSH4 gene. , 1997, Genomics.

[12]  J. Griffith,et al.  MutS mediates heteroduplex loop formation by a translocation mechanism , 1997, The EMBO journal.

[13]  R. Fishel,et al.  The Human Mismatch Recognition Complex hMSH2-hMSH6 Functions as a Novel Molecular Switch , 1997, Cell.

[14]  P. Peltomäki,et al.  Mutations predisposing to hereditary nonpolyposis colorectal cancer: database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer. , 1997, Gastroenterology.

[15]  P. Hsieh,et al.  Interaction of MutS Protein with the Major and Minor Grooves of a Heteroduplex DNA* , 1997, The Journal of Biological Chemistry.

[16]  S R Sprang,et al.  G protein mechanisms: insights from structural analysis. , 1997, Annual review of biochemistry.

[17]  A. de la Chapelle,et al.  Mutations predisposing to hereditary nonpolyposis colorectal cancer. , 1997, Advances in cancer research.

[18]  K. Bjornson,et al.  DNA-dependent Activation of the hMutSα ATPase* , 1998, The Journal of Biological Chemistry.

[19]  L. Gu,et al.  ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair. , 1998, Nucleic acids research.

[20]  R. Fishel.  Mismatch repair, molecular switches, and signal transduction. , 1998, Genes & development.

[21]  Satya Prakash,et al.  ATP-dependent Assembly of a Ternary Complex Consisting of a DNA Mismatch and the Yeast MSH2-MSH6 and MLH1-PMS1 Protein Complexes* , 1998, The Journal of Biological Chemistry.

[22]  R. Fishel,et al.  Interactions of Human hMSH2 with hMSH3 and hMSH2 with hMSH6: Examination of Mutations Found in Hereditary Nonpolyposis Colorectal Cancer , 1998, Molecular and Cellular Biology.

[23]  T. Sokolsky,et al.  A Mutation in the MSH6 Subunit of the Saccharomyces cerevisiae MSH2-MSH6 Complex Disrupts Mismatch Recognition* , 1999, The Journal of Biological Chemistry.

[24]  R. Fishel.  Signaling mismatch repair in cancer , 1999, Nature Medicine.

[25]  J. Tytell,et al.  Germ-line msh6 mutations in colorectal cancer families. , 1999, Cancer research.

[26]  J. Griffith,et al.  hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA. , 1999, Molecular cell.

[27]  R. Fishel,et al.  Dissociation of Mismatch Recognition and ATPase Activity by hMSH2-hMSH3* , 1999, The Journal of Biological Chemistry.

[28]  C. Croce,et al.  hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis. , 1999, Cancer research.

[29]  P. Møller,et al.  Familial endometrial cancer in female carriers of MSH6 germline mutations , 1999, Nature Genetics.

[30]  T. Kunkel,et al.  Functional Interaction of Proliferating Cell Nuclear Antigen with MSH2-MSH6 and MSH2-MSH3 Complexes* , 2000, The Journal of Biological Chemistry.

[31]  P. Tran,et al.  Analysis of yeast MSH2-MSH6 suggests that the initiation of mismatch repair can be separated into discrete steps. , 2000, Journal of molecular biology.

[32]  R. Iyengar,et al.  Signaling Networks The Origins of Cellular Multitasking , 2000, Cell.

[33]  Anastassis Perrakis,et al.  The crystal structure of DNA mismatch repair protein MutS binding to a G·T mismatch , 2000, Nature.

[34]  R. Fishel,et al.  The Role of Mismatched Nucleotides in Activating the hMSH2-hMSH6 Molecular Switch* , 2000, The Journal of Biological Chemistry.

[35]  M. Berardini,et al.  The effect of O6-methylguanine DNA adducts on the adenosine nucleotide switch functions of hMSH2-hMSH6 and hMSH2-hMSH3. , 2000, The Journal of biological chemistry.

[36]  R. Kolodner,et al.  Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex , 2000, Nature Genetics.

[37]  J. Jiricny,et al.  Mismatch Recognition and DNA-dependent Stimulation of the ATPase Activity of hMutSα Is Abolished by a Single Mutation in the hMSH6 Subunit* , 2000, The Journal of Biological Chemistry.

[38]  Wei Yang,et al.  Crystal structures of mismatch repair protein MutS and its complex with a substrate DNA , 2000, Nature.

[39]  T. Kunkel,et al.  Asymmetric Recognition of DNA Local Distortion , 2001, The Journal of Biological Chemistry.

[40]  P. Hsieh,et al.  Composite active site of an ABC ATPase: MutS uses ATP to verify mismatch recognition and authorize DNA repair. , 2001, Molecular cell.

[41]  H. Hollema,et al.  A role for MLH3 in hereditary nonpolyposis colorectal cancer , 2001, Nature Genetics.

[42]  R. Fishel,et al.  The selection for mismatch repair defects in hereditary nonpolyposis colorectal cancer: revising the mutator hypothesis. , 2001, Cancer research.

[43]  K. Kinzler,et al.  The role of hPMS1 and hPMS2 in predisposing to colorectal cancer. , 2001, Cancer research.

[44]  P. Tran,et al.  MSH-MLH complexes formed at a DNA mismatch are disrupted by the PCNA sliding clamp. , 2001, Journal of molecular biology.

[45]  A. Grossman,et al.  Visualization of mismatch repair in bacterial cells. , 2001, Molecular cell.

[46]  P. Hsieh,et al.  Molecular mechanisms of DNA mismatch repair. , 2001, Mutation research.

[47]  Richard Fishel,et al.  Activation of Human MutS Homologs by 8-Oxo-guanine DNA Damage* , 2002, The Journal of Biological Chemistry.

[48]  R. Fishel,et al.  Mismatch Repair and the Hereditary Non-polyposis Colorectal Cancer Syndrome (HNPCC) , 2002, Cancer investigation.