Surface Functionalization of Gold Nanoparticles with Red Blood Cell Membranes

Gold nanoparticles are enclosed in cellular membranes derived from natural red blood cells (RBCs) by a top-down approach. The gold nanoparticles exhibit a complete membrane surface layer and biological characteristics of the source cells. The combination of inorganic gold nanoparticles with biological membranes is a compelling way to develop biomimetic gold nanostructures for future applications, such as those requiring evasion of the immune system.

[1]  Konstantin Sokolov,et al.  Preventing protein adsorption and macrophage uptake of gold nanoparticles via a hydrophobic shield. , 2012, ACS nano.

[2]  Liangfang Zhang,et al.  Erythrocyte‐Inspired Delivery Systems , 2012, Advanced healthcare materials.

[3]  Xiaogang Liu,et al.  Improving colorimetric assays through protein enzyme-assisted gold nanoparticle amplification. , 2012, Accounts of chemical research.

[4]  Stefaan De Smedt,et al.  Cytotoxic effects of gold nanoparticles: a multiparametric study. , 2012, ACS nano.

[5]  Mark R. Servos,et al.  Instantaneous and quantitative functionalization of gold nanoparticles with thiolated DNA using a pH-assisted and surfactant-free route. , 2012, Journal of the American Chemical Society.

[6]  Mostafa A. El-Sayed,et al.  The golden age: gold nanoparticles for biomedicine. , 2012, Chemical Society reviews.

[7]  V. Fulari,et al.  Fluorescence quenching using plasmonic gold nanoparticles , 2011 .

[8]  Ronnie H. Fang,et al.  Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform , 2011, Proceedings of the National Academy of Sciences.

[9]  Z. Fayad,et al.  A fluorescent, paramagnetic and PEGylated gold/silica nanoparticle for MRI, CT and fluorescence imaging. , 2010, Contrast Media & Molecular Imaging.

[10]  Dennis E Discher,et al.  Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels. , 2010, Blood cells, molecules & diseases.

[11]  Chad A. Mirkin,et al.  Gold nanoparticles for biology and medicine. , 2010, Angewandte Chemie.

[12]  Shaoyi Jiang,et al.  Ultralow‐Fouling, Functionalizable, and Hydrolyzable Zwitterionic Materials and Their Derivatives for Biological Applications , 2010, Advanced materials.

[13]  Lei Zhang,et al.  Functionalizable and ultra stable nanoparticles coated with zwitterionic poly(carboxybetaine) in undiluted blood serum. , 2009, Biomaterials.

[14]  Chad A. Mirkin,et al.  Gene regulation with polyvalent siRNA-nanoparticle conjugates. , 2009, Journal of the American Chemical Society.

[15]  Claudia Calcagno,et al.  Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform. , 2008, Nano letters.

[16]  M. van Lookeren Campagne,et al.  Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg. , 2008, Blood.

[17]  Keitaro Yoshimoto,et al.  Completely dispersible PEGylated gold nanoparticles under physiological conditions: modification of gold nanoparticles with precisely controlled PEG-b-polyamine. , 2008, Langmuir : the ACS journal of surfaces and colloids.

[18]  Sabine Neuss,et al.  Size-dependent cytotoxicity of gold nanoparticles. , 2007, Small.

[19]  E. Zubarev,et al.  Paclitaxel-functionalized gold nanoparticles. , 2007, Journal of the American Chemical Society.

[20]  M. Blanchard‐Desce,et al.  Quenching of molecular fluorescence on the surface of monolayer-protected gold nanoparticles investigated using place exchange equilibria. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[21]  Erich Sackmann,et al.  Polymer-supported membranes as models of the cell surface , 2005, Nature.

[22]  Ching-An Peng,et al.  Reduced Phagocytosis of Colloidal Carriers Using Soluble CD47 , 2003, Pharmaceutical Research.

[23]  D. Reinhoudt,et al.  Fluorescence quenching of dye molecules near gold nanoparticles: radiative and nonradiative effects. , 2002, Physical review letters.

[24]  M. L. Hallensleben,et al.  Gold Nanoparticles with Covalently Attached Polymer Chains. , 2001, Angewandte Chemie.

[25]  C. Lagenaur,et al.  Role of CD47 as a marker of self on red blood cells. , 2000, Science.

[26]  R. Waugh,et al.  Effects of lost surface area on red blood cells and red blood cell survival in mice. , 1996, The American journal of physiology.

[27]  M. Spiess,et al.  Heads or tails — what determines the orientation of proteins in the membrane , 1995, FEBS letters.

[28]  H. Müller-Eberhard,et al.  Isolation of a human erythrocyte membrane protein capable of inhibiting expression of homologous complement transmembrane channels. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[29]  M. Shin,et al.  Homologous species restriction in lysis of human erythrocytes: a membrane-derived protein with C8-binding capacity functions as an inhibitor. , 1986, Journal of immunology.

[30]  R M Hochmuth,et al.  Mechanical measurement of red cell membrane thickness. , 1983, Science.

[31]  M. Conrad,et al.  Role of sialic acid in erythrocyte survival , 1975 .

[32]  D. Alling,et al.  AN EVALUATION OF ANTIMALARIAL COMBINATIONS AGAINST PLASMODIUM BERGHEI IN THE MOUSE. , 1963, The Journal of parasitology.

[33]  J. Oncley,et al.  The contribution of sialic acid to the surface charge of the erythrocyte. , 1962, The Journal of biological chemistry.