Using laser capture microdissection to study fiber specific signaling in locomotor muscle in COPD: A pilot study

Quadriceps dysfunction is important in chronic obstructive pulmonary disease (COPD), with an associated increased proportion of type II fibers. Investigation of protein synthesis and degradation has yielded conflicting results, possibly due to study of whole biopsy samples, whereas signaling may be fiber‐specific. Our objective was to develop a method for fiber‐specific gene expression analysis.

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