In vivo measurements of irreversible and reversible transverse relaxation rates in human basal ganglia at 7 T: making inferences about the microscopic and mesoscopic structure of iron and calcification deposits

The goal of this study was to measure irreversible and reversible transverse relaxation rates in the globus pallidus and putamen at 7 T, and to use these rates to make inferences about the sub‐voxel structure of iron and calcification deposits.

[1]  Nikolaus Weiskopf,et al.  Microstructural imaging of human neocortex in vivo , 2018, NeuroImage.

[2]  Dmitry S. Novikov,et al.  Transverse NMR relaxation in biological tissues , 2018, NeuroImage.

[3]  A. Heerschap,et al.  Visualization of calcium phosphate cement in teeth by zero echo time 1H MRI at high field , 2018, NMR in biomedicine.

[4]  Jonathan R. Polimeni,et al.  Advantages of cortical surface reconstruction using submillimeter 7 T MEMPRAGE , 2018, NeuroImage.

[5]  Sebastian Weingärtner,et al.  Gaussian signal relaxation around spin echoes: Implications for precise reversible transverse relaxation quantification of pulmonary tissue at 1.5 and 3 Tesla , 2017, Magnetic resonance in medicine.

[6]  A. MacKay,et al.  Magnetic Resonance of Myelin Water: An in vivo Marker for Myelin , 2016, Brain plasticity.

[7]  C. Tempany-Afdhal,et al.  Characterizing gradient echo signal decays in gynecologic cancers at 3T using a Gaussian augmentation of the monoexponential (GAME) model , 2016, Journal of magnetic resonance imaging : JMRI.

[8]  Onur Afacan,et al.  Fast myelin water fraction estimation using 2D multislice CPMG , 2016, Magnetic resonance in medicine.

[9]  Minh Phuong Nguyen,et al.  The Neuromelanin-related T2* Contrast in Postmortem Human Substantia Nigra with 7T MRI , 2016, Scientific Reports.

[10]  R. Deichmann,et al.  T2’-Imaging to Assess Cerebral Oxygen Extraction Fraction in Carotid Occlusive Disease: Influence of Cerebral Autoregulation and Cerebral Blood Volume , 2016, PloS one.

[11]  F. Fennessy,et al.  Characterization of gradient echo signal decays in healthy and cancerous prostate at 3T improves with a Gaussian augmentation of the mono‐exponential (GAME) model , 2016, NMR in biomedicine.

[12]  Md Nasir Uddin,et al.  Value of transverse relaxometry difference methods for iron in human brain. , 2016, Magnetic resonance imaging.

[13]  Ralf Deichmann,et al.  Quantitative T2, T2*, and T2′ MR imaging in patients with ischemic leukoaraiosis might detect microstructural changes and cortical hypoxia , 2015, Neuroradiology.

[14]  Dimitrios Mitsouras,et al.  On the lorentzian versus Gaussian character of time‐domain spin‐echo signals from the brain as sampled by means of gradient‐echoes: Implications for quantitative transverse relaxation studies , 2015, Magnetic resonance in medicine.

[15]  Thomas Christen,et al.  Comparison of R2′ measurement methods in the normal brain at 3 tesla , 2015, Magnetic resonance in medicine.

[16]  Daniel K Sodickson,et al.  Rapid and accurate T2 mapping from multi–spin‐echo data using Bloch‐simulation‐based reconstruction , 2015, Magnetic resonance in medicine.

[17]  Susumu Mori,et al.  Probing region-specific microstructure of human cortical areas using high angular and spatial resolution diffusion MRI , 2015, NeuroImage.

[18]  G. B. Pike,et al.  MRI‐based myelin water imaging: A technical review , 2015, Magnetic resonance in medicine.

[19]  P. Seevinck,et al.  Simultaneous R2*, R2, and R2′ quantification by combining S0 estimation of the free induction decay with a single spin echo: A single acquisition method for R2 insensitive quantification of holmium‐166–loaded microspheres , 2015, Magnetic resonance in medicine.

[20]  Yi Wang,et al.  Quantitative susceptibility mapping (QSM): Decoding MRI data for a tissue magnetic biomarker , 2014, Magnetic resonance in medicine.

[21]  Ralf Deichmann,et al.  Quantitative T2′-Mapping in Acute Ischemic Stroke , 2014, Stroke.

[22]  M. Neema,et al.  Iron and multiple sclerosis , 2014, Neurobiology of Aging.

[23]  Christian Langkammer,et al.  Differential developmental trajectories of magnetic susceptibility in human brain gray and white matter over the lifespan , 2014, Human brain mapping.

[24]  Ludwig Kappos,et al.  Multicenter R2* mapping in the healthy brain , 2014, Magnetic resonance in medicine.

[25]  Jens Fiehler,et al.  Reversible, irreversible and effective transverse relaxation rates in normal aging brain at 3T , 2014, NeuroImage.

[26]  Tian Liu,et al.  Intracranial calcifications and hemorrhages: characterization with quantitative susceptibility mapping. , 2013, Radiology.

[27]  Friedhelm E Zanella,et al.  T2′‐ and PASL‐based perfusion mapping at 3 Tesla: influence of oxygen‐ventilation on cerebral autoregulation , 2012, Journal of magnetic resonance imaging : JMRI.

[28]  F E Zanella,et al.  Age-Related Changes of Cerebral Autoregulation: New Insights with Quantitative T2′-Mapping and Pulsed Arterial Spin-Labeling MR Imaging , 2012, American Journal of Neuroradiology.

[29]  David H Salat,et al.  Alterations in brain transition metals in Huntington disease: an evolving and intricate story. , 2012, Archives of neurology.

[30]  Xavier Golay,et al.  Reduced R2′ in multiple sclerosis normal appearing white matter and lesions may reflect decreased myelin and iron content , 2012, Journal of Neurology, Neurosurgery & Psychiatry.

[31]  R. Bammer,et al.  Compensation of slice profile mismatch in combined spin‐ and gradient‐echo echo‐planar imaging pulse sequences , 2012, Magnetic resonance in medicine.

[32]  E. Hahn,et al.  Spin Echoes , 2011 .

[33]  P. Gowland,et al.  Simultaneous quantification of T2 and T′2 using a combined gradient echo‐spin echo sequence at ultrahigh field , 2010, Magnetic resonance in medicine.

[34]  R. Lebel,et al.  Transverse relaxometry with stimulated echo compensation , 2010, Magnetic resonance in medicine.

[35]  Maria Grazia Bruzzone,et al.  Age-related iron deposition in the basal ganglia: quantitative analysis in healthy subjects. , 2009, Radiology.

[36]  B. Keil,et al.  Design Optimization of a 32-Channel Head Coil at 7 T , 2009 .

[37]  Götz Thomalla,et al.  T2' imaging predicts infarct growth beyond the acute diffusion-weighted imaging lesion in acute stroke. , 2008, Radiology.

[38]  J Fiehler,et al.  Age-Dependent Normal Values of T2* and T2′ in Brain Parenchyma , 2008, American Journal of Neuroradiology.

[39]  André J. W. van der Kouwe,et al.  Brain morphometry with multiecho MPRAGE , 2008, NeuroImage.

[40]  Vasily L Yarnykh,et al.  Actual flip‐angle imaging in the pulsed steady state: A method for rapid three‐dimensional mapping of the transmitted radiofrequency field , 2007, Magnetic resonance in medicine.

[41]  R. Strecker,et al.  Vessel size imaging in humans , 2005, Magnetic resonance in medicine.

[42]  Hisashi Tanaka,et al.  Determination of transverse relaxation rate for estimating iron deposits in central nervous system , 2005, Neuroscience Research.

[43]  E. Haacke,et al.  Imaging iron stores in the brain using magnetic resonance imaging. , 2005, Magnetic resonance imaging.

[44]  Wilson Fong.  Handbook of MRI Pulse Sequences , 2005 .

[45]  S. Furui,et al.  MRI appearances of calcified regions within intracranial tumours , 2004, Neuroradiology.

[46]  Norihiko Fujita,et al.  Quantitative mapping of cerebral deoxyhemoglobin content using MR imaging , 2003, NeuroImage.

[47]  R. Goebel,et al.  7T vs. 4T: RF power, homogeneity, and signal‐to‐noise comparison in head images , 2001, Magnetic resonance in medicine.

[48]  Michael B. Smith,et al.  Signal‐to‐noise ratio and absorbed power as functions of main magnetic field strength, and definition of “90°” RF pulse for the head in the birdcage coil , 2001, Magnetic resonance in medicine.

[49]  M. Décorps,et al.  Vessel size imaging , 2001, Magnetic resonance in medicine.

[50]  M A Fernández-Seara,et al.  Postprocessing technique to correct for background gradients in image‐based R*2 measurements , 2000, Magnetic resonance in medicine.

[51]  R. Chandra,et al.  MR imaging of microvasculature , 2000, Magnetic resonance in medicine.

[52]  G. Pike,et al.  Correction for B1 and B0 variations in quantitative T2 measurements using MRI , 2000, Magnetic resonance in medicine.

[53]  P D Griffiths,et al.  Iron in the basal ganglia in Parkinson's disease. An in vitro study using extended X-ray absorption fine structure and cryo-electron microscopy. , 1999, Brain : a journal of neurology.

[54]  R A Knight,et al.  MR imaging of human brain at 3.0 T: preliminary report on transverse relaxation rates and relation to estimated iron content. , 1999, Radiology.

[55]  G. Perry,et al.  Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[56]  E M Haacke,et al.  An MRI method for measuring T2 in the presence of static and RF magnetic field Inhomogeneities , 1997, Magnetic resonance in medicine.

[57]  F W Wehrli,et al.  Method for image-based measurement of the reversible and irreversible contribution to the transverse-relaxation rate. , 1996, Journal of magnetic resonance. Series B.

[58]  D. Bihan,et al.  Molecular diffusion, tissue microdynamics and microstructure , 1995 .

[59]  P. Basser.  Inferring microstructural features and the physiological state of tissues from diffusion‐weighted images , 1995, NMR in biomedicine.

[60]  E. Haacke,et al.  Theory of NMR signal behavior in magnetically inhomogeneous tissues: The static dephasing regime , 1994, Magnetic resonance in medicine.

[61]  C. S. Poon,et al.  Practical T2 quantitation for clinical applications , 1992, Journal of magnetic resonance imaging : JMRI.

[62]  R. Henkelman,et al.  High signal intensity in MR images of calcified brain tissue. , 1991, Radiology.

[63]  J. Mugler,et al.  Three‐dimensional magnetization‐prepared rapid gradient‐echo imaging (3D MP RAGE) , 1990, Magnetic resonance in medicine.

[64]  J C Gore,et al.  Errors in the measurements of T2 using multiple‐echo MRI techniques. I. Effects of radiofrequency pulse imperfections , 1986, Magnetic resonance in medicine.

[65]  R. Switzer,et al.  The regional distribution and cellular localization of iron in the rat brain , 1984, Neuroscience.

[66]  J. Thompson,et al.  Neuroradiology of tuberous sclerosis in children. , 1974, Radiology.

[67]  R. Berk,et al.  Idiopathic familial cerebrovascular ferrocalcinosis (Fahr's disease) and review of differential diagnosis of intracranial calcification in children. , 1969, The American journal of roentgenology, radium therapy, and nuclear medicine.

[68]  B. Hallgren,et al.  THE EFFECT OF AGE ON THE NON‐HAEMIN IRON IN THE HUMAN BRAIN , 1958, Journal of neurochemistry.

[69]  S. Meiboom,et al.  Modified Spin‐Echo Method for Measuring Nuclear Relaxation Times , 1958 .

[70]  E. Purcell,et al.  Effects of Diffusion on Free Precession in Nuclear Magnetic Resonance Experiments , 1954 .