Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1.

[1]  S. Janmohamed,et al.  Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential. , 2010, Cell stem cell.

[2]  Andreas Trumpp,et al.  Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair , 2008, Cell.

[3]  Allen D. Delaney,et al.  Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. , 2009, Blood.

[4]  S. Morrison,et al.  Hematopoietic stem cells do not depend on N-cadherin to regulate their maintenance. , 2009, Cell stem cell.

[5]  A. Iwama,et al.  TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. , 2009, Blood.

[6]  Nathan C Boles,et al.  Mouse hematopoietic stem cell identification and analysis , 2009, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

[7]  Ingo Roeder,et al.  Characterization and quantification of clonal heterogeneity among hematopoietic stem cells: a model-based approach. , 2008, Blood.

[8]  P. Lio’,et al.  Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair , 2008, Cell.

[9]  M. Le Bousse-Kerdilès,et al.  A Cross‐Talk Between Stromal Cell‐Derived Factor‐1 and Transforming Growth Factor‐β Controls the Quiescence/Cycling Switch of CD34+ Progenitors Through FoxO3 and Mammalian Target of Rapamycin , 2008, Stem cells.

[10]  H. Sieburg,et al.  A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells. , 2008, Blood.

[11]  Nathan C Boles,et al.  CD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells. , 2008, Blood.

[12]  Steven B. Bradfute,et al.  Hematopoietic fingerprints: an expression database of stem cells and their progeny. , 2007, Cell stem cell.

[13]  Ryan Brinkman,et al.  Long-term propagation of distinct hematopoietic differentiation programs in vivo. , 2007, Cell stem cell.

[14]  Chad A Shaw,et al.  Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation , 2007, PLoS biology.

[15]  M. Ramalho-Santos,et al.  On the origin of the term "stem cell". , 2007, Cell stem cell.

[16]  I. Weissman,et al.  Hematopoietic stem cell aging: Mechanism and consequence , 2007, Experimental Gerontology.

[17]  Eric Jervis,et al.  High-resolution video monitoring of hematopoietic stem cells cultured in single-cell arrays identifies new features of self-renewal. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[18]  C. Eaves,et al.  The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets. , 2006, Blood.

[19]  C. Esmon,et al.  Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow. , 2006, Blood.

[20]  F. Camargo,et al.  Hematopoietic stem cells do not engraft with absolute efficiencies. , 2006, Blood.

[21]  Irving L. Weissman,et al.  Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates , 2005, The Journal of experimental medicine.

[22]  G. van Zant,et al.  Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. , 2005, Blood.

[23]  S. Morrison,et al.  Supplemental Experimental Procedures , 2022 .

[24]  I. Weissman,et al.  Cell intrinsic alterations underlie hematopoietic stem cell aging. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[25]  H. Nakauchi,et al.  Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice. , 2005, Developmental cell.

[26]  S. Karlsson,et al.  Quiescence of hematopoietic stem cells and maintenance of the stem cell pool is not dependent on TGF-beta signaling in vivo. , 2005, Experimental hematology.

[27]  A. Vaidya,et al.  Molecular mechanisms behind the dose-dependent differential activation of MAPK pathways induced by transforming growth factor-beta1 in hematopoietic cells. , 2004, Stem cells and development.

[28]  C. Shaw,et al.  Molecular Signatures of Proliferation and Quiescence in Hematopoietic Stem Cells , 2004, PLoS biology.

[29]  V. Kale,et al.  Differential activation of MAPK signaling pathways by TGF-beta1 forms the molecular mechanism behind its dose-dependent bidirectional effects on hematopoiesis. , 2004, Stem cells and development.

[30]  L. Karlsson,et al.  Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness. , 2004, Blood.

[31]  高野 弥奈.  Asymmetric division and lineage commitment at the level of hematopoietic stem cells : inference from differentiation in daughter cell and granddaughter cell pairs , 2004 .

[32]  H. Okano,et al.  Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells. , 2004, Immunity.

[33]  C. Eaves,et al.  Different in vivo repopulating activities of purified hematopoietic stem cells before and after being stimulated to divide in vitro with the same kinetics. , 2003, Experimental hematology.

[34]  M. Goumans,et al.  TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro. , 2003, Blood.

[35]  G. Nucifora,et al.  The role of EVI1 in normal and leukemic cells. , 2003, Blood cells, molecules & diseases.

[36]  G. Spangrude,et al.  Major Age‐Related Changes Of Mouse Hematopoietic Stem/Progenitor Cells , 2003, Annals of the New York Academy of Sciences.

[37]  H. Sieburg,et al.  Deterministic regulation of hematopoietic stem cell self-renewal and differentiation. , 2002, Blood.

[38]  S. Jacobsen,et al.  Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity. , 2001, Immunity.

[39]  H. Nakauchi,et al.  The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype , 2001, Nature Medicine.

[40]  H. Nakauchi,et al.  Age-Associated Characteristics of Murine Hematopoietic Stem Cells , 2000, The Journal of experimental medicine.

[41]  I. Weissman,et al.  A clonogenic common myeloid progenitor that gives rise to all myeloid lineages , 2000, Nature.

[42]  N. Fortunel,et al.  Release from Quiescence of Primitive Human Hematopoietic Stem/Progenitor Cells by Blocking Their Cell‐Surface TGF‐β Type II Receptor in a Short‐Term In Vitro Assay , 2000, Stem cells.

[43]  Susumu Goto,et al.  KEGG: Kyoto Encyclopedia of Genes and Genomes , 2000, Nucleic Acids Res..

[44]  Hiroyuki Ogata,et al.  KEGG: Kyoto Encyclopedia of Genes and Genomes , 1999, Nucleic Acids Res..

[45]  Cindy L. Miller,et al.  Expansion in vitro of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[46]  R. Johnson,et al.  Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species , 1997, Nature Medicine.

[47]  I. Weissman,et al.  Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow , 1997, Cell.

[48]  I. Weissman,et al.  The aging of hematopoietic stem cells , 1996, Nature Medicine.

[49]  C. Eaves,et al.  Identification of properties that can distinguish primitive populations of stromal-cell-responsive lympho-myeloid cells from cells that are stromal-cell-responsive but lymphoid-restricted and cells that have lympho-myeloid potential but are also capable of competitively repopulating myeloablated rec , 1996, Blood.

[50]  K. Moore,et al.  Functional heterogeneity of the hematopoietic microenvironment: rare stromal elements maintain long-term repopulating stem cells. , 1996, Blood.

[51]  A. S. Conner,et al.  Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo , 1996, The Journal of experimental medicine.

[52]  D. Brooks,et al.  Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function. , 1995, Blood.

[53]  I. Weissman,et al.  The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. , 1994, Immunity.

[54]  D. Longo,et al.  Recombinant transforming growth factor beta 1 and beta 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin , 1994, The Journal of experimental medicine.

[55]  D. Soprano,et al.  Induction of c‐fos and c‐jun mRNA at the M/G1 border is required for cell cycle progression , 1994, Journal of cellular biochemistry.

[56]  G. Spangrude.  Characteristics of the hematopoietic stem cell compartment in adult mice. , 1992, International journal of cell cloning.

[57]  I. Weissman,et al.  Clonal analysis of hematopoietic stem-cell differentiation in vivo. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[58]  C. Eaves,et al.  Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[59]  J. Wagner,et al.  Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells , 1990, Nature.

[60]  I. Lemischka,et al.  Clonal and systemic analysis of long-term hematopoiesis in the mouse. , 1990, Genes & development.

[61]  Ihor R. Lemischka,et al.  Developmental potential and dynamic behavior of hematopoietic stem cells , 1986, Cell.