Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

[1]  Xiaoling Xu,et al.  A Role of Smad4 in Iron Metabolism through the Positive Regulation of Hepcidin Expression , 2022 .

[2]  A. West,et al.  Interaction of Hemojuvelin with Neogenin Results in Iron Accumulation in Human Embryonic Kidney 293 Cells* , 2005, Journal of Biological Chemistry.

[3]  C. Woolf,et al.  Repulsive Guidance Molecule (RGMa), a DRAGON Homologue, Is a Bone Morphogenetic Protein Co-receptor* , 2005, Journal of Biological Chemistry.

[4]  S. Arber,et al.  Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. , 2005, The Journal of clinical investigation.

[5]  G. Pinkus,et al.  A mouse model of juvenile hemochromatosis. , 2005, The Journal of clinical investigation.

[6]  A. Brivanlou,et al.  DRAGON, a Bone Morphogenetic Protein Co-receptor* , 2005, Journal of Biological Chemistry.

[7]  E. Beutler,et al.  Regulation of hepcidin transcription by interleukin-1 and interleukin-6. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Jerry Kaplan,et al.  Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization , 2004, Science.

[9]  E. Nečas,et al.  Expression of Rgmc, the murine ortholog of hemojuvelin gene, is modulated by development and inflammation, but not by iron status or erythropoietin. , 2004, Blood.

[10]  Jiandie D. Lin,et al.  Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice , 2004, Cell.

[11]  N. Andrews,et al.  Identification of a novel mutation (C321X) in HJV. , 2004, Blood.

[12]  S. Strittmatter,et al.  RGM and its receptor neogenin regulate neuronal survival , 2004, Nature Cell Biology.

[13]  Srikanth Rajagopalan,et al.  Neogenin mediates the action of repulsive guidance molecule , 2004, Nature Cell Biology.

[14]  J. Barton,et al.  Genetic abnormalities and juvenile hemochromatosis: mutations of the HJV gene encoding hemojuvelin. , 2004, Blood.

[15]  M. Cazzola,et al.  Spectrum of hemojuvelin gene mutations in 1q-linked juvenile hemochromatosis. , 2004, Blood.

[16]  Herbert Y. Lin,et al.  In the Absence of Type III Receptor, the Transforming Growth Factor (TGF)-β Type II-B Receptor Requires the Type I Receptor to Bind TGF-β2* , 2004, Journal of Biological Chemistry.

[17]  Elizabeta Nemeth,et al.  IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. , 2004, The Journal of clinical investigation.

[18]  M. Hentze,et al.  Balancing Acts Molecular Control of Mammalian Iron Metabolism , 2004, Cell.

[19]  C. Woolf,et al.  DRAGON: A Member of the Repulsive Guidance Molecule-Related Family of Neuronal- and Muscle-Expressed Membrane Proteins Is Regulated by DRG11 and Has Neuronal Adhesive Properties , 2004, The Journal of Neuroscience.

[20]  S. Arber,et al.  Repulsive Guidance Molecule (RGM) Gene Function Is Required for Neural Tube Closure But Not Retinal Topography in the Mouse Visual System , 2004, The Journal of Neuroscience.

[21]  J. Massagué,et al.  Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus , 2003, Cell.

[22]  Elizabeta Nemeth,et al.  Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. , 2003, Blood.

[23]  Guang-Quan Zhao,et al.  Consequences of knocking out BMP signaling in the mouse , 2003, Genesis.

[24]  Markus Affolter,et al.  Structural basis of BMP signalling inhibition by the cystine knot protein Noggin , 2002, Nature.

[25]  D. Gilot,et al.  C/EBPα Regulates Hepatic Transcription of Hepcidin, an Antimicrobial Peptide and Regulator of Iron Metabolism , 2002, The Journal of Biological Chemistry.

[26]  W. Van Hul,et al.  Extracellular regulation of BMP signaling in vertebrates: a cocktail of modulators. , 2002, Developmental biology.

[27]  Gaël Nicolas,et al.  The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. , 2002, The Journal of clinical investigation.

[28]  Matthias Mann,et al.  RGM is a repulsive guidance molecule for retinal axons , 2002, Nature.

[29]  P. ten Dijke,et al.  Identification and Functional Characterization of Distinct Critically Important Bone Morphogenetic Protein-specific Response Elements in the Id1 Promoter* , 2002, The Journal of Biological Chemistry.

[30]  P. Schirmacher,et al.  Hepatocellular expression of a dominant-negative mutant TGF-β type II receptor accelerates chemically induced hepatocarcinogenesis , 2001, Oncogene.

[31]  C. Beaumont,et al.  Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[32]  P. Donahoe,et al.  Müllerian inhibiting substance signaling uses a bone morphogenetic protein (BMP)-like pathway mediated by ALK2 and induces SMAD6 expression. , 2001, Molecular endocrinology.

[33]  Christina H. Park,et al.  Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver* , 2001, The Journal of Biological Chemistry.

[34]  Bruno Turlin,et al.  A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload* , 2001, The Journal of Biological Chemistry.

[35]  Peter Schulz-Knappe,et al.  LEAP‐1, a novel highly disulfide‐bonded human peptide, exhibits antimicrobial activity , 2000, FEBS letters.

[36]  P. Hoodless,et al.  Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2* , 1998, The Journal of Biological Chemistry.

[37]  Denis Vivien,et al.  Direct binding of Smad3 and Smad4 to critical TGFβ‐inducible elements in the promoter of human plasminogen activator inhibitor‐type 1 gene , 1998, The EMBO journal.

[38]  G. Ramadori,et al.  Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1. , 1997, Experimental cell research.

[39]  V. Rogiers,et al.  Transforming growth factor-β gene expression in normal and fibrotic rat liver , 1997 .

[40]  B. Hogan,et al.  Bone morphogenetic proteins: multifunctional regulators of vertebrate development. , 1996, Genes & development.

[41]  N. LaRusso,et al.  Recent advances in the isolation of liver cells , 1994, Hepatology.

[42]  M. Sporn,et al.  Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts. , 1984, The Journal of biological chemistry.

[43]  A. Minty,et al.  Comparison of three actin-coding sequences in the mouse; Evolutionary relationships between the actin genes of warm-blooded vertebrates , 2005, Journal of Molecular Evolution.

[44]  T. Ganz,et al.  Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. , 2005, Blood.

[45]  Marie-Pierre Dubé,et al.  Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis , 2004, Nature Genetics.

[46]  Seppo Parkkila,et al.  Hepatic and extrahepatic expression of the new iron regulatory protein hemojuvelin. , 2004, Haematologica.

[47]  Herbert Y. Lin,et al.  In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2. , 2004, The Journal of biological chemistry.

[48]  J. Massagué,et al.  Mechanisms of TGF-beta signaling from cell membrane to the nucleus. , 2003, Cell.

[49]  D. Girelli,et al.  Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis , 2003, Nature Genetics.

[50]  D. Gilot,et al.  C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. , 2002, The Journal of biological chemistry.

[51]  N. Rosenblum,et al.  BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways. , 2001, American journal of physiology. Renal physiology.

[52]  R. Eisenstein Iron regulatory proteins and the molecular control of mammalian iron metabolism. , 2000, Annual review of nutrition.

[53]  V. Rogiers,et al.  Transforming growth factor-beta gene expression in normal and fibrotic rat liver. , 1997, Journal of hepatology.

[54]  D. Kingsley,et al.  What do BMPs do in mammals? Clues from the mouse short-ear mutation. , 1994, Trends in genetics : TIG.