Mitochondrial-Encoded Peptide MOTS-c is an Exercise-Induced Regulator of Aging Metabolic Homeostasis and Physical Capacity
暂无分享,去创建一个
James H. Joly | B. Benayoun | P. Cohen | Changhan Lee | D. Cameron-Smith | N. Graham | Ryan J. Lu | C. Mitchell | T. Merry | J. Woodhead | Rochelle W. Lai | J. Joly | Joseph C. Reynolds | Jonathan S. T. Woodhead | B. Benayoun
[1] Changhan Lee,et al. Mouse Fitness as Determined Through Treadmill Running and Walking. , 2020, Methods in molecular biology.
[2] T. Finkel,et al. Mitochondria as intracellular signaling platforms in health and disease , 2020, The Journal of cell biology.
[3] D. Davidson,et al. Antimicrobial host defence peptides: functions and clinical potential , 2020, Nature Reviews Drug Discovery.
[4] Jing Yuanyuan,et al. Protective effect of MOTS-c on acute lung injury induced by lipopolysaccharide in mice. , 2020, International immunopharmacology.
[5] A. Zimmer,et al. Internalization mechanisms of cell-penetrating peptides , 2020, Beilstein journal of nanotechnology.
[6] Xinqiang Yin,et al. The intraperitoneal administration of MOTS-c produces antinociceptive and anti-inflammatory effects through the activation of AMPK pathway in the mouse formalin test. , 2020, European journal of pharmacology.
[7] P. Tontonoz,et al. Inter-organ cross-talk in metabolic syndrome , 2019, Nature Metabolism.
[8] J. Auwerx,et al. Mitocellular communication: Shaping health and disease , 2019, Science.
[9] Wanli W. Smith,et al. Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway , 2019, Cardiorenal Medicine.
[10] S. Inouye,et al. Enabling Healthful Aging for All - The National Academy of Medicine Grand Challenge in Healthy Longevity. , 2019, The New England journal of medicine.
[11] Zhao Yan,et al. MOTS-c inhibits Osteolysis in the Mouse Calvaria by affecting osteocyte-osteoclast crosstalk and inhibiting inflammation. , 2019, Pharmacological research.
[12] P. Kapahi,et al. From discoveries in ageing research to therapeutics for healthy ageing , 2019, Nature.
[13] P. Cohen,et al. The mitochondrial‐derived peptide MOTS‐c is a regulator of plasma metabolites and enhances insulin sensitivity , 2019, Physiological reports.
[14] S. Atkin,et al. Mitochondrial-Derived Peptides Are Down Regulated in Diabetes Subjects , 2019, Front. Endocrinol..
[15] Zhao Yan,et al. Earlier changes in mice after D-galactose treatment were improved by mitochondria derived small peptide MOTS-c. , 2019, Biochemical and biophysical research communications.
[16] S. Atkin,et al. Lipids and insulin regulate mitochondrial‐derived peptide (MOTS‐c) in PCOS and healthy subjects , 2019, Clinical endocrinology.
[17] Ying Liu,et al. Mitochondrial-Derived Peptide MOTS-c Increases Adipose Thermogenic Activation to Promote Cold Adaptation , 2019, International journal of molecular sciences.
[18] Param Priya Singh,et al. The Genetics of Aging: A Vertebrate Perspective , 2019, Cell.
[19] M. Thevis,et al. Development of a mass spectrometry based detection method for the mitochondrion-derived peptide MOTS-c in plasma samples for doping control purposes. , 2019, Rapid communications in mass spectrometry : RCM.
[20] Huanyu Lu,et al. MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction , 2019, Journal of Molecular Medicine.
[21] D. Cameron-Smith,et al. Peripheral blood mononuclear cells do not reflect skeletal muscle mitochondrial function or adaptation to high-intensity interval training in healthy young men. , 2019, Journal of applied physiology.
[22] Larry Cuban,et al. The Starting Line , 2019, Bumpy Road.
[23] J. Son,et al. Mitochondria: multifaceted regulators of aging , 2019, BMB reports.
[24] Damian Szklarczyk,et al. STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets , 2018, Nucleic Acids Res..
[25] L. Galluzzi,et al. Linking cellular stress responses to systemic homeostasis , 2018, Nature Reviews Molecular Cell Biology.
[26] S. Olshansky,et al. From Lifespan to Healthspan , 2018, JAMA.
[27] S. Austad,et al. Aging as a Biological Target for Prevention and Therapy. , 2018, JAMA.
[28] W. Wong. Going nuclear with stress , 2018, Science Signaling.
[29] G. Shadel,et al. A Mitochondrial-Derived Peptide Exercises the Nuclear Option. , 2018, Cell metabolism.
[30] B. Benayoun,et al. The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress. , 2018, Cell metabolism.
[31] B. Tang,et al. A Mitochondrial Encoded Messenger at the Nucleus , 2018, Cells.
[32] T. Finkel,et al. The role of mitochondria in aging , 2018, The Journal of clinical investigation.
[33] W. Wimley,et al. Synthetic molecular evolution of hybrid cell penetrating peptides , 2018, Nature Communications.
[34] D. Allison,et al. Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice , 2018, Nature Communications.
[35] Param Priya Singh,et al. Remodeling of epigenome and transcriptome landscapes with aging in mice reveals widespread induction of inflammatory responses , 2018, bioRxiv.
[36] Q. Ning,et al. Circulating MOTS‐c levels are decreased in obese male children and adolescents and associated with insulin resistance , 2018, Pediatric diabetes.
[37] R. Houtkooper,et al. Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease , 2018, Endocrine reviews.
[38] J. Galgani,et al. Plasma MOTS-c levels are associated with insulin sensitivity in lean but not in obese individuals , 2018, Journal of Investigative Medicine.
[39] L. Guarente,et al. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging , 2018, Cell.
[40] R. Morimoto,et al. Rethinking HSF1 in Stress, Development, and Organismal Health. , 2017, Trends in cell biology.
[41] João Pedro de Magalhães,et al. The Business of Anti-Aging Science. , 2017, Trends in biotechnology.
[42] P. Cohen,et al. Mitochondrially derived peptides as novel regulators of metabolism , 2017, The Journal of physiology.
[43] J. Auwerx,et al. Mitochondria and Epigenetics - Crosstalk in Homeostasis and Stress. , 2017, Trends in cell biology.
[44] B. Goodpaster,et al. Metabolic Flexibility in Health and Disease. , 2017, Cell metabolism.
[45] P. Bénit,et al. Mitochondria are physiologically maintained at close to 50 °C , 2017, bioRxiv.
[46] T. Nyström,et al. The Upsides and Downsides of Organelle Interconnectivity , 2017, Cell.
[47] N. Larsson,et al. Mammalian Mitochondria and Aging: An Update. , 2017, Cell metabolism.
[48] P. Schrauwen,et al. Skeletal muscle mitochondria as a target to prevent or treat type 2 diabetes mellitus , 2016, Nature Reviews Endocrinology.
[49] M. Ristow,et al. Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? , 2016, The Journal of physiology.
[50] Carlos López-Otín,et al. Metabolic Control of Longevity , 2016, Cell.
[51] Huanyu Lu,et al. Mitochondria related peptide MOTS-c suppresses ovariectomy-induced bone loss via AMPK activation. , 2016, Biochemical and biophysical research communications.
[52] S. Kritchevsky,et al. Metformin as a Tool to Target Aging. , 2016, Cell metabolism.
[53] Andrew D. Rouillard,et al. Enrichr: a comprehensive gene set enrichment analysis web server 2016 update , 2016, Nucleic Acids Res..
[54] Lior Pachter,et al. Near-optimal probabilistic RNA-seq quantification , 2016, Nature Biotechnology.
[55] H. Naito,et al. Relation between type 2 diabetes and m.1382 A>C polymorphism which occurs amino acid replacement (K14Q) of mitochondria‐derived MOTS‐c , 2016 .
[56] J. Auwerx,et al. Mitonuclear communication in homeostasis and stress , 2016, Nature Reviews Molecular Cell Biology.
[57] S. Hekimi,et al. Mitochondrial dysfunction and longevity in animals: Untangling the knot , 2015, Science.
[58] P. Rabinovitch,et al. Healthy aging: The ultimate preventative medicine , 2015, Science.
[59] Eileen M. Crimmins,et al. Lifespan and Healthspan: Past, Present, and Promise. , 2015, The Gerontologist.
[60] I. Laher,et al. Exercise Pills: At the Starting Line. , 2015, Trends in pharmacological sciences.
[61] A. Lucia,et al. The role of mitochondrial derived peptides (MDPs) in metabolism , 2015, Journal of cellular physiology.
[62] Randy Strong,et al. NIA Interventions Testing Program: Investigating Putative Aging Intervention Agents in a Genetically Heterogeneous Mouse Model , 2015, EBioMedicine.
[63] A. Lucia,et al. The mitochondrial‐derived peptide MOTS‐c: a player in exceptional longevity? , 2015, Aging cell.
[64] Claude Bouchard,et al. Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits. , 2015, Cell metabolism.
[65] S. Groshen,et al. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. , 2015, Cell metabolism.
[66] M. Ristow,et al. A mitochondrially encoded hormone ameliorates obesity and insulin resistance. , 2015, Cell metabolism.
[67] Changhan Lee,et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. , 2015, Cell metabolism.
[68] W. Huber,et al. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 , 2014, Genome Biology.
[69] J. Hawley,et al. Integrative Biology of Exercise , 2014, Cell.
[70] E. Schadt,et al. Geroscience: Linking Aging to Chronic Disease , 2014, Cell.
[71] M. B. Jensen,et al. Mitochondrial proteostasis in the control of aging and longevity. , 2014, Cell metabolism.
[72] H. Van Remmen,et al. Mitochondrial stress signaling in longevity: A new role for mitochondrial function in aging , 2014, Redox Biology.
[73] Manuel Serrano,et al. The Hallmarks of Aging , 2013, Cell.
[74] P. Cohen,et al. Humanin: a harbinger of mitochondrial-derived peptides? , 2013, Trends in Endocrinology & Metabolism.
[75] A. Bratić,et al. The role of mitochondria in aging. , 2013, The Journal of clinical investigation.
[76] J. Zierath,et al. Exercise metabolism and the molecular regulation of skeletal muscle adaptation. , 2013, Cell metabolism.
[77] Guangchuang Yu,et al. clusterProfiler: an R package for comparing biological themes among gene clusters. , 2012, Omics : a journal of integrative biology.
[78] L. Sistonen,et al. Regulation of HSF1 function in the heat stress response: implications in aging and disease. , 2011, Annual review of biochemistry.
[79] A. Dillin,et al. The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity , 2011, Cell.
[80] C. Finch,et al. The Demographic and Biomedical Case for Late-Life Interventions in Aging , 2010, Science Translational Medicine.
[81] Linda Partridge,et al. Extending Healthy Life Span—From Yeast to Humans , 2010, Science.
[82] Marco Pahor,et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice , 2009, Nature.
[83] K. Davies,et al. Free radicals and exercise: an introduction. , 2008, Free radical biology & medicine.
[84] H. Aburatani,et al. Upregulation of Heat Shock Transcription Factor 1 Plays a Critical Role in Adaptive Cardiac Hypertrophy , 2006, Circulation research.
[85] F. McArdle,et al. Adaptive responses of mouse skeletal muscle to contractile activity: The effect of age , 2006, Mechanisms of Ageing and Development.
[86] Pablo Tamayo,et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[87] S. Dunnett,et al. Motor Coordination and Balance in Rodents , 2001, Current protocols in neuroscience.
[88] Scott D. Thomson,et al. An Introduction , 1977 .
[89] J. Bergström. Percutaneous Needle Biopsy of Skeletal Muscle in Physiological and Clinical Research , 1975 .
[90] H. Naito,et al. Amino Acid Replacement (K14Q) of Mitochondria-Derived MOTS-c Affects Type 2 Diabetes in Men with Lower Physical Activity , 2018 .
[91] John D. Storey,et al. Supplementary Text: Capturing Heterogeneity in Gene Expression Studies Nested Ks-tests: a Procedure to Test Whether a Procedure Is Valid , 2022 .
[92] J. Leek. Surrogate variable analysis , 2007 .
[93] Maynard W. Glitman. Upsides and Downsides , 2006 .
[94] K. Johnson. An Update. , 1984, Journal of food protection.