Non-invasive monitoring of BMP-2 retention and bone formation in composites for bone tissue engineering using SPECT/CT and scintillation probes.

[1]  T. Hefferan,et al.  Non-invasive screening method for simultaneous evaluation of in vivo growth factor release profiles from multiple ectopic bone tissue engineering implants. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[2]  Michael J Yaszemski,et al.  Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering. , 2008, Biomaterials.

[3]  Hans-Ulrich Gremlich,et al.  In Vivo mouse imaging and spectroscopy in drug discovery , 2007, NMR in biomedicine.

[4]  A. Khademhosseini,et al.  Bone regeneration through controlled release of bone morphogenetic protein-2 from 3-D tissue engineered nano-scaffold. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[5]  Y. Tabata,et al.  Controlled-release of epidermal growth factor from cationized gelatin hydrogel enhances corneal epithelial wound healing. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[6]  A G Mikos,et al.  In vivo release of rhBMP-2 loaded porous calcium phosphate cement pretreated with albumin , 2006, Journal of materials science. Materials in medicine.

[7]  Manuel Baro,et al.  Validation of a method for non-invasive in vivo measurement of growth factor release from a local delivery system in bone. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[8]  D. Piwnica-Worms,et al.  Molecular imaging strategies for drug discovery and development. , 2006, Current opinion in chemical biology.

[9]  Lichun Lu,et al.  Bone-tissue-engineering material poly(propylene fumarate): correlation between molecular weight, chain dimensions, and physical properties. , 2006, Biomacromolecules.

[10]  A G Mikos,et al.  Controlled release of rhBMP-2 loaded poly(dl-lactic-co-glycolic acid)/calcium phosphate cement composites in vivo. , 2005, Journal of controlled release : official journal of the Controlled Release Society.

[11]  Y. Tabata,et al.  Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponge composed of gelatin and beta-tricalcium phosphate. , 2005, Biomaterials.

[12]  B. Cornelissen,et al.  A review of small animal imaging planar and pinhole spect Gamma camera imaging. , 2005, Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association.

[13]  F. Rose,et al.  Delivery systems for bone growth factors — the new players in skeletal regeneration , 2004, The Journal of pharmacy and pharmacology.

[14]  Henry C. Vasconez,et al.  Enhancement of Bone Growth by Sustained Delivery of Recombinant Human Bone Morphogenetic Protein-2 in a Polymeric Matrix , 2001, Pharmaceutical Research.

[15]  Y. Tabata,et al.  Controlled release by biodegradable hydrogels enhances the ectopic bone formation of bone morphogenetic protein. , 2003, Biomaterials.

[16]  T. Uchida,et al.  Release of recombinant human bone morphogenetic protein 2 from a newly developed carrier. , 2003, International journal of pharmaceutics.

[17]  H. Seeherman,et al.  Retention of 125I‐labeled recombinant human bone morphogenetic protein‐2 by biphasic calcium phosphate or a composite sponge in a rabbit posterolateral spine arthrodesis model , 2002, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[18]  H. Uludaǧ,et al.  Effect of molecular weight of thermoreversible polymer on in vivo retention of rhBMP-2. , 2001, Journal of biomedical materials research.

[19]  B L Currier,et al.  Biological activity of rhBMP-2 released from PLGA microspheres. , 2000, Journal of biomechanical engineering.

[20]  J. Wozney,et al.  Implantation of recombinant human bone morphogenetic proteins with biomaterial carriers: A correlation between protein pharmacokinetics and osteoinduction in the rat ectopic model. , 2000, Journal of biomedical materials research.

[21]  Y. Ikada,et al.  Bone regeneration by transforming growth factor beta1 released from a biodegradable hydrogel. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[22]  R. Zernicke,et al.  Bone Affinity of a Bisphosphonate‐Conjugated Protein in Vivo , 2000, Biotechnology progress.

[23]  H. Uludaǧ,et al.  Characterization of absorbable collagen sponges as rhBMP-2 carriers. , 1999, International journal of pharmaceutics.

[24]  J. Wozney,et al.  Characterization of rhBMP-2 pharmacokinetics implanted with biomaterial carriers in the rat ectopic model. , 1999, Journal of biomedical materials research.

[25]  S M Jorgensen,et al.  Three-dimensional imaging of vasculature and parenchyma in intact rodent organs with X-ray micro-CT. , 1998, The American journal of physiology.

[26]  T. Walz,et al.  Uptake of 125I-PDGF-AB to the blood after extravascular administration in mice. , 1998, Life sciences.

[27]  J. Vacanti,et al.  Tissue engineering : Frontiers in biotechnology , 1993 .

[28]  S M Larson,et al.  Radioimmunodetection in cancer identification. , 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[29]  S. Adelstein,et al.  Iodine-125 cytotoxicity: implications for therapy and estimation of radiation risk. , 1981, International journal of nuclear medicine and biology.

[30]  I. Doniach,et al.  Biological effects of 131I and 125I isotopes of iodine in the rat. , 1976, The Journal of endocrinology.