Los adenovirus como causa de gastroenteritis aguda en los niños

Objetivo: Identificar tempranamente los adenovirus en ninos con gastroenteritis aguda. Metodos: Estudio retrospectivo, se seleccionaron 1,619 ninos menores de 16 anos con diagnostico de gastroenteritis infecciosa que ingresaron al hospital en los ultimos cuatro anos; de estos a 501 se les hizo la prueba de diagnostico rapido en la busqueda de adenovirus en heces. Resultados: La frecuencia de los adenovirus fue de 9.9% en su mayoria lactantes. Las manifestaciones clinicas fueron un cuadro subagudo de diarrea profusa, acuosa y mucosa, con una duracion media de cuatro dias; en 40 (80%) ninos hubo vomito, la mitad tuvo fiebre, dolor y distension abdominal. Solo hubo un caso con deshidratacion severa; la biometria mostro una cuenta leucocitaria normal con monocitosis y linfocitosis. Conclusion: Los adenovirus son causa de gastroenteritis aguda en menores de dos anos, por lo que se recomienda la prueba rapida para hacer un diagnostico precoz y evitar el empleo de antibioticos en estos ninos

[1]  S. Okitsu,et al.  Prevalence, seasonality, and peak age of infection of enteric adenoviruses in Japan, 1995–2009 , 2012, Epidemiology and Infection.

[2]  M. Zaghloul.  Adenovirus Serotypes (40,41) as a Cause of Gastroenteritis , 2012 .

[3]  F. Liprandi,et al.  Molecular epidemiology of enteric viruses in children with sporadic gastroenteritis in Valencia, Venezuela , 2011, Journal of medical virology.

[4]  P. Coyle,et al.  Development and clinical validation of multiplex TaqMan® assays for rapid diagnosis of viral gastroenteritis. , 2011, Journal of medical virology.

[5]  Pengbo Liu,et al.  Symptomatic and asymptomatic infections of rotavirus, norovirus, and adenovirus among hospitalized children in Xi'an, China , 2011, Journal of medical virology.

[6]  E. Şevketoğlu,et al.  Incidence assessment of rotavirus and adenovirus associated acute gastroenteritis cases in early childhood. , 2011, Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive.

[7]  Hernández Cortez Cecilia,et al.  Situación de las enfermedades gastrointestinales en México , 2011 .

[8]  J. Mesquita,et al.  Outbreak of acute gastroenteritis caused by adenovirus type 41 in a kindergarten , 2010, Epidemiology and Infection.

[9]  T. Ramamurthy,et al.  Circulation of a Novel Pattern of Infections by Enteric Adenovirus Serotype 41 among Children below 5 Years of Age in Kolkata, India , 2010, Journal of Clinical Microbiology.

[10]  E. Claas,et al.  Diagnosis of viral gastroenteritis by simultaneous detection of Adenovirus group F, Astrovirus, Rotavirus group A, Norovirus genogroups I and II, and Sapovirus in two internally controlled multiplex real-time PCR assays. , 2010, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[11]  K. Nourijelyani,et al.  Prevalence of Rotavirus, Adenovirus, and Astrovirus Infections among Patients with Acute Gastroenteritis in, Northern Iran , 2010, Iranian journal of public health.

[12]  N. Lévêque,et al.  Prevalence of Rotavirus, Adenovirus, Norovirus, and Astrovirus Infections and Coinfections among Hospitalized Children in Northern France , 2010, Journal of Clinical Microbiology.

[13]  Maureen B Taylor,et al.  High prevalence of species D human adenoviruses in fecal specimens from Urban Kenyan children with diarrhea , 2010, Journal of medical virology.

[14]  K. Grimwood,et al.  Acute and persistent diarrhea. , 2009, Pediatric clinics of North America.

[15]  N. Sakly,et al.  Molecular epidemiology of human astrovirus and adenovirus serotypes 40/41 strains related to acute diarrhea in Tunisian children , 2009, Journal of medical virology.

[16]  K. Bányai,et al.  Searching for HAdV-52, the putative gastroenteritis-associated human adenovirus serotype in Southern Hungary. , 2009, The new microbiologica.

[17]  K. Bányai,et al.  Adenovirus gastroenteritis in Hungary, 2003–2006 , 2009, European Journal of Clinical Microbiology & Infectious Diseases.

[18]  P. Garner,et al.  Antimicrobial drugs for persistent diarrhoea of unknown or non-specific cause in children under six in low and middle income countries: systematic review of randomized controlled trials , 2009, BMC infectious diseases.

[19]  P. Khamrin,et al.  Molecular characterization of rotaviruses, noroviruses, sapovirus, and adenoviruses in patients with acute gastroenteritis in Thailand , 2009, Journal of medical virology.

[20]  H. Pérez-Cano,et al.  Polimorfismo del gen TLR2 como factor de riesgo en la infección oftálmica por adenovirus , 2009 .

[21]  Z. Fedorowicz,et al.  Antiemetics for reducing vomiting related to acute gastroenteritis in children and adolescents. , 2009, The Cochrane database of systematic reviews.

[22]  M. Al-Ahdal,et al.  Enteric viruses in pediatric diarrhea in Saudi Arabia , 2008, Journal of medical virology.

[23]  Menira Souza,et al.  Adenovirus, calicivirus and astrovirus detection in fecal samples of hospitalized children with acute gastroenteritis from Campo Grande, MS, Brazil. , 2008, Memorias do Instituto Oswaldo Cruz.

[24]  K. Reither,et al.  Molecular characterization of enteric viral agents from children in northern region of Ghana , 2008, Journal of medical virology.

[25]  A. Carraturo,et al.  Microbiological and epidemiological aspects of rotavirus and enteric adenovirus infections in hospitalized children in Italy. , 2008, The new microbiologica.

[26]  A. Petrinca,et al.  Influence of enteric viruses on gastroenteritis in Albania: Epidemiological and molecular analysis , 2007, Journal of medical virology.

[27]  A. Steele,et al.  Adenovirus infection in children with diarrhea disease in Northwestern Nigeria. , 2007, Annals of African medicine.

[28]  J. Dawson,et al.  Genotype prevalence and risk factors for severe clinical adenovirus infection, United States 2004-2006. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[29]  H. O’Shea,et al.  Prevalence and characterization of enteric adenoviruses in the South of Ireland , 2007, Journal of medical virology.

[30]  K. T. Hoang,et al.  Diversity of viruses associated with acute gastroenteritis in children hospitalized with diarrhea in Ho Chi Minh City, Vietnam , 2007, Journal of medical virology.

[31]  E. Delwart,et al.  New Adenovirus Species Found in a Patient Presenting with Gastroenteritis , 2007, Journal of Virology.

[32]  M. Kieny,et al.  A review of vaccine research and development: human enteric infections. , 2006, Vaccine.

[33]  M. Sinclair,et al.  Pathogens causing community gastroenteritis in Australia , 2005, Journal of gastroenterology and hepatology.

[34]  Á. Domínguez,et al.  Rotavirus y adenovirus 40–41 como causantes de gastroenteritis infantil , 2004, Vacunas.

[35]  R. Glass,et al.  Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy. , 2003, MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports.

[36]  G. Gaedicke,et al.  Viral agents of acute gastroenteritis in German children: Prevalence and molecular diversity , 2003, Journal of medical virology.

[37]  M. Iturriza-Gómara,et al.  Infantile viral gastroenteritis: On the way to closing the diagnostic gap , 2003, Journal of medical virology.

[38]  J. Santiago,et al.  Adenovirus en un grupo de pacientes con infección respiratoria aguda , 2002 .

[39]  Benito Regueiro,et al.  Diarrea por adenovirus y astrovirus en pacientes inmunodeficientes hospitalizados , 2001 .

[40]  R. Davis,et al.  Perinatal Risk Factors for Infant Hospitalization With Viral Gastroenteritis , 1999, Pediatrics.

[41]  G. Staatz,et al.  [Intestinal infection, the most frequent cause of invagination in childhood: results of a 10-year clinical study]. , 1998, Klinische Padiatrie.

[42]  H. Greenberg,et al.  MEDICAL PROGRESS: VIRAL GASTROENTERITIS , 1991 .

[43]  M. Levine,et al.  Enteric adenovirus infection and childhood diarrhea: an epidemiologic study in three clinical settings. , 1989, Pediatrics.

[44]  F. Puerto,et al.  Role of rotavirus and enteric adenovirus in acute paediatric diarrhoea at an urban hospital in Mexico. , 1989, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[45]  D. Wood.  Adenovirus gastroenteritis , 1988, British medical journal.

[46]  I. Uhnoo,et al.  Enzyme‐linked immunosorbent assay for detection of enteric adenovirus 41 , 1985, Journal of medical virology.

[47]  L. Svensson,et al.  Importance of enteric adenoviruses 40 and 41 in acute gastroenteritis in infants and young children , 1984, Journal of clinical microbiology.

[48]  J. D. de Jong,et al.  Candidate adenoviruses 40 and 41: Fastidious adenoviruses from human infant stool , 1983, Journal of medical virology.