Glutathione, N-acetylcysteine and Lipoic Acid Down-Regulate Starvation-Induced Apoptosis, RANKL/OPG Ratio and Sclerostin in Osteocytes: Involvement of JNK and ERK1/2 Signalling

[1]  O. Kennedy,et al.  Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo. , 2014, Bone.

[2]  Weili Yan,et al.  Effect of oral ALA supplementation on oxidative stress and insulin sensitivity among overweight/obese adults: a double-blinded, randomized, controlled, cross-over intervention trial. , 2013, International journal of cardiology.

[3]  Ivo Kalajzic,et al.  In vitro and in vivo approaches to study osteocyte biology. , 2013, Bone.

[4]  M. Brandi,et al.  Role of GSH/GSSG redox couple in osteogenic activity and osteoclastogenic markers of human osteoblast‐like SaOS‐2 cells , 2012, The FEBS journal.

[5]  R. Weinstein,et al.  Osteocyte apoptosis. , 2013, Bone.

[6]  T. Bellido.  Osteocyte-Driven Bone Remodeling , 2013, Calcified Tissue International.

[7]  T. Aw,et al.  Glutathione and modulation of cell apoptosis. , 2012, Biochimica et biophysica acta.

[8]  B. Clarke.  Relationship of Age to Bone Microstructure Independent of Areal Bone Mineral Density , 2012 .

[9]  M. Rotondi,et al.  Oral supplementation with antioxidant agents containing alpha lipoic acid: effects on postmenopausal bone mass. , 2012, Clinical and experimental obstetrics & gynecology.

[10]  G. Boss,et al.  Pro-survival Effects of 17β-Estradiol on Osteocytes Are Mediated by Nitric Oxide/cGMP via Differential Actions of cGMP-dependent Protein Kinases I and II* , 2011, The Journal of Biological Chemistry.

[11]  L. You,et al.  Apoptotic osteocytes regulate osteoclast precursor recruitment and differentiation in vitro , 2011, Journal of cellular biochemistry.

[12]  T. C. Lee,et al.  RANKL and OPG activity is regulated by injury size in networks of osteocyte-like cells. , 2011, Bone.

[13]  L. Bonewald,et al.  The Amazing Osteocyte , 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[14]  Tak Yee Aw,et al.  Reactive oxygen species, cellular redox systems, and apoptosis. , 2010, Free radical biology & medicine.

[15]  C. L. Benhamou,et al.  Osteocyte: the unrecognized side of bone tissue , 2010, Osteoporosis International.

[16]  Y. Turan,et al.  Antioxidant status in patients with osteoporosis: a controlled study. , 2009, Joint, bone, spine : revue du rhumatisme.

[17]  A. Evdokiou,et al.  Pro‐Inflammatory Cytokines TNF‐Related Weak Inducer of Apoptosis (TWEAK) and TNFα Induce the Mitogen‐Activated Protein Kinase (MAPK)‐Dependent Expression of Sclerostin in Human Osteoblasts , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[18]  M. Karsdal,et al.  Local communication on and within bone controls bone remodeling. , 2009, Bone.

[19]  O. Verborgt,et al.  Osteocyte Apoptosis Controls Activation of Intracortical Resorption in Response to Bone Fatigue , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[20]  Sylvia Notenboom,et al.  Glutathione dysregulation and the etiology and progression of human diseases , 2009, Biological chemistry.

[21]  L. Bonewald,et al.  Gene expression signatures of a fibroblastoid preosteoblast and cuboidal osteoblast cell model compared to the MLO-Y4 osteocyte cell model. , 2009, Bone.

[22]  D. Fyhrie,et al.  Modulation of sclerostin expression by mechanical loading and bone morphogenetic proteins in osteogenic cells. , 2009, Biorheology.

[23]  G. Banfi,et al.  Oxidative stress, free radicals and bone remodeling , 2008, Clinical chemistry and laboratory medicine.

[24]  Mark L. Johnson,et al.  Osteocytes, mechanosensing and Wnt signaling. , 2008, Bone.

[25]  Z. Lee,et al.  N‐acetylcysteine stimulates osteoblastic differentiation of mouse calvarial cells , 2008, Journal of cellular biochemistry.

[26]  M. Kotowicz,et al.  Potential role of the antioxidant N-acetylcysteine in slowing bone resorption in early post-menopausal women: a pilot study. , 2007, Translational research : the journal of laboratory and clinical medicine.

[27]  F. Collins,et al.  The antioxidant effect of estrogen and Selective Estrogen Receptor Modulators in the inhibition of osteocyte apoptosis in vitro. , 2007, Bone.

[28]  S. Curtiss,et al.  Quantitative regional associations between remodeling, modeling, and osteocyte apoptosis and density in rabbit tibial midshafts. , 2007, Bone.

[29]  R. Franco,et al.  The central role of glutathione in the pathophysiology of human diseases , 2007, Archives of physiology and biochemistry.

[30]  B. Bjelakovic,et al.  Glucocorticoids and oxidative stress , 2007, Journal of basic and clinical physiology and pharmacology.

[31]  A. Parfitt,et al.  Osteocyte Apoptosis Is Induced by Weightlessness in Mice and Precedes Osteoclast Recruitment and Bone Loss , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[32]  Ki-Up Lee,et al.  α‐Lipoic Acid Inhibits TNF‐α‐Induced Apoptosis in Human Bone Marrow Stromal Cells , 2005 .

[33]  Hong-Hee Kim,et al.  α-Lipoic acid suppresses osteoclastogenesis despite increasing the receptor activator of nuclear factor κB ligand/osteoprotegerin ratio in human bone marrow stromal cells , 2005 .

[34]  B. Noble.  Microdamage and apoptosis. , 2005, European journal of morphology.

[35]  S. Manolagas,et al.  Bisphosphonates and Estrogens Inhibit Osteocyte Apoptosis via Distinct Molecular Mechanisms Downstream of Extracellular Signal-regulated Kinase Activation* , 2005, Journal of Biological Chemistry.

[36]  T. Chambers,et al.  Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation. , 2005, Endocrinology.

[37]  Hyunsook Kim,et al.  Alpha-lipoic acid suppresses osteoclastogenesis despite increasing the receptor activator of nuclear factor kappaB ligand/osteoprotegerin ratio in human bone marrow stromal cells. , 2005, The Journal of endocrinology.

[38]  Ki-Up Lee,et al.  Alpha-lipoic acid inhibits TNF-alpha-induced apoptosis in human bone marrow stromal cells. , 2005, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[39]  P. Nijweide,et al.  Fas/CD95 is associated with glucocorticoid-induced osteocyte apoptosis. , 2004, Life sciences.

[40]  Jenneke Klein-Nulend,et al.  Shear stress inhibits while disuse promotes osteocyte apoptosis. , 2004, Biochemical and biophysical research communications.

[41]  M. Widlansky,et al.  Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. , 2004, Current medicinal chemistry.

[42]  Hang Zheng,et al.  Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. , 2004, Biochemical and biophysical research communications.

[43]  P. Nasser,et al.  The Role of Interstitial Fluid Flow in the Remodeling Response to Fatigue Loading , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[44]  C. Hamanishi,et al.  Hydrogen Peroxide Induces Apoptosis of Osteocytes: Involvement of Calcium Ion and Caspase Activity , 2002, Calcified Tissue International.

[45]  N. Holbrook,et al.  Oxidants, oxidative stress and the biology of ageing , 2000, Nature.

[46]  R. Weinstein,et al.  Apoptosis of osteocytes in glucocorticoid-induced osteonecrosis of the hip. , 2000, The Journal of clinical endocrinology and metabolism.

[47]  O. Verborgt,et al.  Loss of Osteocyte Integrity in Association with Microdamage and Bone Remodeling After Fatigue In Vivo , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[48]  G. Greendale,et al.  The Relation of Dietary Vitamin C Intake to Bone Mineral Density: Results from the PEPI Study , 1998, Calcified Tissue International.

[49]  L. Bonewald,et al.  Establishment of an Osteocyte‐like Cell Line, MLO‐Y4 , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.