An Inspection of our Working Hypotheses in the Study of Pain and other Subjective Responses in Man

The working hypotheses of primary importance in our laboratory effort over the past 15 years have been set down. These hypotheses have been credited with playing a considerable part in the opening up of a new field in pharmacology: The quantitative study of the effects ;of drugs on the mind. Since this work has been carried out in man, usually sick man, it provides another example of the fundamental importance of the clinic in the advancement of special basic areas in pharmacology and psychology. Die wichtigsten Arbeitshypothesen für die Laboratoriumsuntersuchungen, die Vortragender während der letzten 15 Jahre durchgeführt hat, werden dargelegt. Diesen Hypothesen wird ein beträchtlicher Anteil eingeräumt an der Erschließung eines neuen Bereichs der Pharmakologie: der quantitativen Erforschung der Wirkung von Arzneimitteln auf die Psyche. Die Ergebnisse wurden im allgemeinen an kranken Menschen gewonnen und zeigen erneut die fundamentale Bedeutung der Klinik für die Grundlagenforschung in der Pharmakologie und Psychologie.

[1]  H. Beecher Surgery as placebo. A quantitative study of bias. , 1961, JAMA.

[2]  H. Beecher,et al.  Increased Stress and Effectiveness of Placebos and "Active" Drugs , 1960, Science.

[3]  H. Beecher,et al.  Amphetamine, secobarbital, and athletic performance. II. Subjective evaluations of performance, mood states, and physical states. , 1960, Journal of the American Medical Association.

[4]  H. Beecher Evidence for increased effectiveness of placebos with increased stress. , 1956, The American journal of physiology.

[5]  L. Lasagna,et al.  Drug-induced mood changes in man. II. Personality and reactions to drugs. , 1955, Journal of the American Medical Association.

[6]  L. Lasagna,et al.  The optimal dose of morphine. , 1954, Journal of the American Medical Association.

[7]  H. Beecher,et al.  Effect of antitussive agents on experimental and pathological cough in man. , 1954, Journal of applied physiology.

[8]  A. Keats,et al.  Pain relief with hypnotic doses of barbiturates and a hypothesis. , 1950, The Journal of pharmacology and experimental therapeutics.

[9]  F. Mosteller,et al.  Measurement of pathological pain in distinction to experimental pain. , 1950, Journal of applied physiology.

[10]  H. Beecher Pain in men wounded in battle. , 1946, Bulletin of the U.S. Army Medical Department. United States. Army. Medical Department.