Human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down‐regulate proliferative responses of primed allogeneic peripheral blood mononuclear cells after rechallenge with antigens

Human colonic intraepithelial lymphocytes from control subjects down‐regulate the proliferative responses of primed allogeneic peripheral blood mononuclear cells on rechallenge with antigens or phytohaemagglutinin (PHA). In contrast, human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down‐regulate the proliferative responses of primed allogeneic peripheral blood mononuclear cells on rechallenge with antigens. These findings may be important in the development and maintenance of the mucosal immunological activation of inflammatory bowel disease.

[1]  D. Jewell,et al.  Epithelial cells bearing class II molecules stimulate allogeneic human colonic intraepithelial lymphocytes. , 1992, Gut.

[2]  H. Dalton,et al.  Human colonic intra‐epithelial lymphocytes are suppressor cells , 1991, Clinical and experimental immunology.

[3]  E. Ebert.  Intra‐epithelial lymphocytes: interferon‐gamma production and suppressor/cytotoxic activities , 1990, Clinical and experimental immunology.

[4]  L. Mayer,et al.  Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease. , 1990, The Journal of clinical investigation.

[5]  E. Ebert.  Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli. , 1989, Gastroenterology.

[6]  P. Krajči,et al.  Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes. , 1989, Gastroenterology.

[7]  J. McFadden,et al.  Mycobacteria and Crohn's disease. , 1988, Gut.

[8]  L. Mayer,et al.  Evidence for function of Ia molecules on gut epithelial cells in man , 1987, The Journal of experimental medicine.

[9]  E. Ebert,et al.  Examination of the low proliferative capacity of human jejunal intraepithelial lymphocytes. , 1986, Clinical and Experimental Immunology.

[10]  P. Bland,et al.  Antigen presentation by epithelial cells of the rat small intestine. I. Kinetics, antigen specificity and blocking by anti-Ia antisera. , 1986, Immunology.

[11]  P. Bland,et al.  Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells. , 1986, Immunology.

[12]  C. Griscelli,et al.  Intraepithelial lymphocytes of human gut: isolation, characterisation and study of natural killer activity. , 1985, Gut.

[13]  D. Jewell,et al.  Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques. , 1984, Gut.

[14]  W. O. Dobbins,et al.  In vitro characterization of human intestinal intraepithelial lymphocytes. , 1983, Gastroenterology.

[15]  R. Tait,et al.  Analysis of natural killer effector and suppressor activity by intraepithelial lymphocytes from mouse small intestine. , 1983, Clinical and experimental immunology.

[16]  R. Palacios.  Mechanism of T Cell Activation: Role and Functional Relationship of HLA‐DR Antigens and Interleukins , 1982, Immunological reviews.

[17]  D. Jewell,et al.  Chronic immune colitis in rabbits. , 1979, Gut.

[18]  P. Perlmann,et al.  IMMUNOLOGICAL STUDIES IN ULCERATIVE COLITIS , 1968, The Journal of experimental medicine.

[19]  P. Perlmann,et al.  AUTOANTIBODIES IN HUMAN ULCERATIVE COLITIS , 1959, The Journal of experimental medicine.

[20]  E. Ebert,et al.  Spontaneous cytotoxicity of human intraepithelial lymphocytes against epithelial cell tumors. , 1992, Gastroenterology.

[21]  H. L. MacKechnie.  The immunology of inflammatory bowel disease. , 1982, Henry Ford Hospital medical journal.

[22]  W. Bartnik,et al.  Leukocyte migration inhibitory factor (LMIF) release by human colonic lymphocytes. , 1981, Archivum immunologiae et therapiae experimentalis.