Targeting Metabolic-Redox Circuits for Cancer Therapy.

[1]  Y. Assaraf,et al.  Modulating ROS to overcome multidrug resistance in cancer. , 2018, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

[2]  J. Xiong Fatty Acid Oxidation in Cell Fate Determination. , 2018, Trends in biochemical sciences.

[3]  Y. Liu,et al.  Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth , 2018, Nature Communications.

[4]  S. Pervaiz Redox Dichotomy in Cell Fate Decision: Evasive Mechanism or Achilles Heel? , 2018, Antioxidants & redox signaling.

[5]  M. Long,et al.  Redox Signaling by Reactive Electrophiles and Oxidants. , 2018, Chemical reviews.

[6]  Qiao Wu,et al.  Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation. , 2018, Molecular cell.

[7]  Yuquan Wei,et al.  Identification of ANXA2 (annexin A2) as a specific bleomycin target to induce pulmonary fibrosis by impeding TFEB-mediated autophagic flux , 2018, Autophagy.

[8]  Joe T. Sharick,et al.  Pharmacological Blockade of ASCT2-dependent Glutamine Transport Leads To Anti-tumor Efficacy in Preclinical Models , 2017, Nature Medicine.

[9]  W. Friedrichs,et al.  NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance , 2017, Nature Communications.

[10]  Benjamin F. Cravatt,et al.  Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer , 2017, Cell.

[11]  E. Nice,et al.  Redox regulation in tumor cell epithelial–mesenchymal transition: molecular basis and therapeutic strategy , 2017, Signal Transduction and Targeted Therapy.

[12]  S. Venneti,et al.  Glutaminolysis: A Hallmark of Cancer Metabolism. , 2017, Annual review of biomedical engineering.

[13]  Sheng-Cai Lin,et al.  Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK , 2017, Nature.

[14]  D. Tuveson,et al.  ROS in Cancer: The Burning Question. , 2017, Trends in molecular medicine.

[15]  J. Neuzil,et al.  Mitochondrial Complex II: At the Crossroads. , 2017, Trends in biochemical sciences.

[16]  Joshua D Rabinowitz,et al.  One-Carbon Metabolism in Health and Disease. , 2017, Cell metabolism.

[17]  Michael P. Lisanti,et al.  Cancer metabolism: a therapeutic perspective , 2017, Nature Reviews Clinical Oncology.

[18]  F. D. De Braud,et al.  Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions. , 2016, Cancer discovery.

[19]  Wei Zhou,et al.  Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer. , 2016, Molecular cell.

[20]  Karen H. Vousden,et al.  Serine and one-carbon metabolism in cancer , 2016, Nature Reviews Cancer.

[21]  A. Schulze,et al.  The multifaceted roles of fatty acid synthesis in cancer , 2016, Nature Reviews Cancer.

[22]  N. Hay,et al.  Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? , 2016, Nature Reviews Cancer.

[23]  M. Hornsveld,et al.  The Hallmarks of Cancer from a Redox Perspective. , 2016, Antioxidants & redox signaling.

[24]  Chi V. Dang,et al.  From Krebs to clinic: glutamine metabolism to cancer therapy , 2016, Nature Reviews Cancer.

[25]  Yuquan Wei,et al.  PRKAA/AMPK restricts HBV replication through promotion of autophagic degradation , 2016, Autophagy.

[26]  Navdeep S. Chandel,et al.  Fundamentals of cancer metabolism , 2016, Science Advances.

[27]  A. Olson,et al.  Proteome-wide covalent ligand discovery in native biological systems , 2016, Nature.

[28]  R. Chhipa,et al.  Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer. , 2016, Trends in pharmacological sciences.

[29]  C. Collins,et al.  The MCT4 Gene: A Novel, Potential Target for Therapy of Advanced Prostate Cancer , 2016, Clinical Cancer Research.

[30]  Eugenia G. Giannopoulou,et al.  Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH , 2015, Science.

[31]  M. Bergo,et al.  Antioxidants can increase melanoma metastasis in mice , 2015, Science Translational Medicine.

[32]  S. Demo,et al.  Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition. , 2015, Blood.

[33]  R. Deberardinis,et al.  Metabolic dysregulation in monogenic disorders and cancer — finding method in madness , 2015, Nature Reviews Cancer.

[34]  A. McCallion,et al.  Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis. , 2015, The Journal of clinical investigation.

[35]  S. Inoue,et al.  Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. , 2015, Cancer cell.

[36]  P. Schumacker Reactive oxygen species in cancer: a dance with the devil. , 2015, Cancer cell.

[37]  F. Gräter,et al.  A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation. , 2015, Nature chemical biology.

[38]  P. Schumacker,et al.  Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? , 2014, Nature Reviews Cancer.

[39]  N. Hay,et al.  The pentose phosphate pathway and cancer. , 2014, Trends in biochemical sciences.

[40]  D. Tuveson,et al.  The promise and perils of antioxidants for cancer patients. , 2014, The New England journal of medicine.

[41]  C. Deng,et al.  Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase. , 2014, Cancer research.

[42]  T. Finkel,et al.  Cellular mechanisms and physiological consequences of redox-dependent signalling , 2014, Nature Reviews Molecular Cell Biology.

[43]  N. Chandel,et al.  ROS Function in Redox Signaling and Oxidative Stress , 2014, Current Biology.

[44]  I. Amelio,et al.  Serine and glycine metabolism in cancer☆ , 2014, Trends in biochemical sciences.

[45]  C. Tsang,et al.  Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance , 2014, Nature Communications.

[46]  Jennifer B Dennison,et al.  Antitumor Activity of the Glutaminase Inhibitor CB-839 in Triple-Negative Breast Cancer , 2014, Molecular Cancer Therapeutics.

[47]  E. Larsson,et al.  Antioxidants Accelerate Lung Cancer Progression in Mice , 2014, Science Translational Medicine.

[48]  J. Sadoshima,et al.  A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation. , 2013, Cell metabolism.

[49]  T. Mak,et al.  Modulation of oxidative stress as an anticancer strategy , 2013, Nature Reviews Drug Discovery.

[50]  J. Trent,et al.  Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer , 2013, Molecular Cancer Therapeutics.

[51]  Yuquan Wei,et al.  Redox homeostasis: the linchpin in stem cell self-renewal and differentiation , 2013, Cell Death and Disease.

[52]  Pier Paolo Pandolfi,et al.  Cancer metabolism: fatty acid oxidation in the limelight , 2013, Nature Reviews Cancer.

[53]  Taro Hitosugi,et al.  Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. , 2012, Cancer cell.

[54]  X. Shu,et al.  Vitamin intake and liver cancer risk: a report from two cohort studies in China. , 2012, Journal of the National Cancer Institute.

[55]  Shiyong Wu,et al.  A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo , 2012, Molecular Cancer Therapeutics.

[56]  Jason W. Locasale,et al.  Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses , 2011, Science.

[57]  J. Crowley,et al.  Vitamin E and the Risk of Prostate Cancer The Selenium and Vitamin E Cancer Prevention Trial ( SELECT ) , 2011 .

[58]  P. Sutphin,et al.  Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality , 2011, Science Translational Medicine.

[59]  T. Mak,et al.  Regulation of cancer cell metabolism , 2011, Nature Reviews Cancer.

[60]  E. Abraham,et al.  Exposure to Hydrogen Peroxide Induces Oxidation and Activation of AMP-activated Protein Kinase* , 2010, The Journal of Biological Chemistry.

[61]  C. Low,et al.  Potential use of the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer. , 2010, Current oncology.

[62]  W. Wheaton,et al.  Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity , 2010, Proceedings of the National Academy of Sciences.

[63]  K. Kinzler,et al.  Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells , 2009, Science.

[64]  Peng Huang,et al.  Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? , 2009, Nature Reviews Drug Discovery.

[65]  M. Gail,et al.  Total and cancer mortality after supplementation with vitamins and minerals: follow-up of the Linxian General Population Nutrition Intervention Trial. , 2009, Journal of the National Cancer Institute.

[66]  Michael P. Murphy,et al.  How mitochondria produce reactive oxygen species , 2008, The Biochemical journal.

[67]  V. Shoshan-Barmatz,et al.  Methyl jasmonate binds to and detaches mitochondria-bound hexokinase , 2008, Oncogene.

[68]  D. Townsend,et al.  NOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance. , 2008, Cancer research.

[69]  R. Meacham,et al.  Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. , 2008, Cancer research.

[70]  Michael Schrader,et al.  Peroxisomes and oxidative stress. , 2006, Biochimica et biophysica acta.

[71]  Jinsong Liu,et al.  Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. , 2006, Cancer cell.

[72]  N. Savaraj,et al.  2-Deoxy-d-glucose Increases the Efficacy of Adriamycin and Paclitaxel in Human Osteosarcoma and Non-Small Cell Lung Cancers In Vivo , 2004, Cancer Research.

[73]  O. Dalesio,et al.  EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the EUropean Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups. , 2000, Journal of the National Cancer Institute.

[74]  W. Earnshaw,et al.  Induction of apoptosis by cancer chemotherapy. , 2000, Experimental cell research.

[75]  J. Zweier,et al.  Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts , 1997, Science.

[76]  G. Omenn,et al.  Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. , 1996, The New England journal of medicine.

[77]  D. Albanes,et al.  The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. , 1994, The New England journal of medicine.

[78]  M. Gail,et al.  Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. , 1993, Journal of the National Cancer Institute.

[79]  O. Griffith Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. , 1982, The Journal of biological chemistry.

[80]  O. Warburg,et al.  THE METABOLISM OF TUMORS IN THE BODY , 1927, The Journal of general physiology.