Engineering Biomaterials for Regenerative Medicine: Novel Technologies for Clinical Applications

Preface: The clinical imperative for regenerative medicine(Sujata K. Bhatia, Harvard University) Cellular Recruitment and Delivery CHAPTER 1. Biomaterial surfaces for the isolation of hematopoietic stem and progenitor cells (Srinivas D. Narasipura and Michael R. King, Cornell University) CHAPTER 2. Matrix stiffness: A regulator of cellular behavior and tissue formation (Brooke N. Mason, Joseph P. Califano, and Cynthia A. Reinhart-King, Cornell University) Oxygen Delivery CHAPTER 3. Oxygen supply for tissue engineering (Whitney L. Stoppel and Susan C. Roberts, University of Massachusetts-Amherst) Tuning of Mechanical Properties CHAPTER 4. Adhesion behavior of soft materials (Santanu Kundu, National Institute of Standards and Technology, and Edwin P. Chan, University of Massachusetts-Amherst) CHAPTER 5. PLA-PEO-PLA hydrogels and their mechanical properties(Gregory N. Tew and Surita R. Bhatia, University of Massachusetts-Amherst) Control of Inflammation and Host Response CHAPTER 6. Host response to biomaterials (Anjelica L. Gonzalez-Simon, Yale University, and Omolola Eniola-Adefeso, University of Michigan) CHAPTER 7. Modulation of the wound healing response through oxidation active materials (Paritosh P. Wattamwar and Thomas D. Dziubla, University of Kentucky) Biologically Inspired Materials for Tissue Regeneration CHAPTER 8. Gecko-inspired tape-based adhesives (Woo Kyung Cho, Maria Jose Maio Nunes Pereira, Nora Lang, Kyungheon Lee, Shwetha Mureli, Andreas Zumbuehl, Cathryn Sundback, Peter T. Masiakos, David J. D. Carter, Jeffrey Borenstein, Lino Ferreira, Robert Langer, and Jeffrey M. Karp, Harvard-MIT) CHAPTER 9. Heparin-functionalized materials in tissue engineering applications (Christopher McGann and Kristi Kiick, University of Delaware) Clinical Applications of Tissue Regeneration CHAPTER 10. Tissue engineering strategies for vocal fold repair and regeneration (Alexandra J. E. Farran, Zhixiang Tong, Robert L. Witt, and Xinqiao Jia, University of Delaware) CHAPTER 11. Non-viral gene delivery for applications in regenerative medicine (Kory Blocker and Millicent Sullivan, University of Delaware) CHAPTER 12. Chitosan-based delivery system for tissue regeneration and chemotherapy (Sungwoo Kim and Yunzhi Yang, University of Texas Health Science Center) CHAPTER 13. Conclusion: Translating tissue engineering into successful therapies (Sujata K. Bhatia, Harvard University)

[1]  Kayla J Bayless,et al.  Molecular basis of endothelial cell morphogenesis in three‐dimensional extracellular matrices , 2002, The Anatomical record.

[2]  P. Tan,et al.  Immunolipoplexes: an efficient, nonviral alternative for transfection of human dendritic cells with potential for clinical vaccination. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[3]  M. Heidaran,et al.  Molecular Signaling in Bioengineered Tissue Microenvironments , 2002, Annals of the New York Academy of Sciences.

[4]  L. Chandler,et al.  Delivery of FGF genes to wound repair cells enhances arteriogenesis and myogenesis in skeletal muscle. , 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

[5]  P. Felgner,et al.  Converting an alcohol to an amine in a cationic lipid dramatically alters the co-lipid requirement, cellular transfection activity and the ultrastructure of DNA-cytofectin complexes. , 1996, Biochimica et biophysica acta.

[6]  Daniel G. Anderson,et al.  Biodegradable polymeric vectors for gene delivery to human endothelial cells. , 2006, Bioconjugate chemistry.

[7]  W. Friess,et al.  Collagen--biomaterial for drug delivery. , 1998, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[8]  Christopher B. Rives,et al.  Plasmid delivery in vivo from porous tissue-engineering scaffolds: transgene expression and cellular transfection. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

[9]  Jae-Hyung Jang,et al.  Controllable delivery of non-viral DNA from porous scaffolds. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[10]  T. Segura,et al.  Substrate-mediated DNA delivery: role of the cationic polymer structure and extent of modification. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[11]  T. Niidome,et al.  Gene Therapy Progress and Prospects: Nonviral vectors , 2002, Gene Therapy.

[12]  P. Carmeliet.  Mechanisms of angiogenesis and arteriogenesis , 2000, Nature Medicine.

[13]  P. Jost,et al.  A novel peptide, THALWHT, for the targeting of human airway epithelia , 2001, FEBS letters.

[14]  T. Segura,et al.  DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach. , 2005, Biomaterials.

[15]  Thomas A. Mustoe, MD, FACS,et al.  Gene delivery through cell culture substrate adsorbed DNA complexes. , 2005, Biotechnology and bioengineering.

[16]  Kristi S. Anseth,et al.  Gene Delivery in Tissue Engineering: A Photopolymer Platform to Coencapsulate Cells and Plasmid DNA , 2003, Pharmaceutical Research.

[17]  W. Pardridge,et al.  Drug and gene targeting to the brain with molecular trojan horses , 2002, Nature Reviews Drug Discovery.

[18]  Daniel W Pack,et al.  Microspheres for controlled release drug delivery , 2004, Expert opinion on biological therapy.

[19]  S. Goldstein,et al.  Stimulation of new bone formation by direct transfer of osteogenic plasmid genes. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[20]  David A. Williams,et al.  Colocalization of retrovirus and target cells on specific fibronectin fragments increases genetic transduction of mammalian cells , 1996, Nature Medicine.

[21]  Roberto Cattaneo,et al.  Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded , 2008, Nature Reviews Microbiology.

[22]  B. Olsen,et al.  Delivery of plasmid DNA to articular chondrocytes via novel collagen-glycosaminoglycan matrices. , 2002, Human gene therapy.

[23]  Seungpyo Hong,et al.  Interaction of polycationic polymers with supported lipid bilayers and cells: nanoscale hole formation and enhanced membrane permeability. , 2006, Bioconjugate chemistry.

[24]  D. Scherman,et al.  Gene transfer by naked DNA into adult mouse brain. , 1996, Gene therapy.

[25]  C. Plank,et al.  Nonviral vector loaded collagen sponges for sustained gene delivery in vitro and in vivo , 2002, The journal of gene medicine.

[26]  H. Farhood,et al.  The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer. , 1995, Biochimica et biophysica acta.

[27]  J. Hubbell,et al.  Development of growth factor fusion proteins for cell‐triggered drug delivery , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[28]  D. Mooney,et al.  Long-term in vivo gene expression via delivery of PEI-DNA condensates from porous polymer scaffolds. , 2005, Human gene therapy.

[29]  G. Kwon,et al.  Encapsulation of plasmid DNA in biodegradable poly(D, L-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[30]  R. Lechler,et al.  TRANSFERRIN RECEPTOR-MEDIATED GENE TRANSFER TO THE CORNEAL ENDOTHELIUM1 , 2001, Transplantation.

[31]  D. Mooney,et al.  Combined Angiogenic and Osteogenic Factor Delivery Enhances Bone Marrow Stromal Cell‐Driven Bone Regeneration , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[32]  R. Scheule.  The role of CpG motifs in immunostimulation and gene therapy. , 2000, Advanced drug delivery reviews.

[33]  R. Levy,et al.  Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles , 2000, Gene Therapy.

[34]  R. Vile,et al.  Targeted vectors for gene therapy , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[35]  R. Mumper,et al.  Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[36]  Y. Capan,et al.  Influence of formulation parameters on the characteristics of poly(D, L-lactide-co-glycolide) microspheres containing poly(L-lysine) complexed plasmid DNA. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[37]  Jae‐Hyung Jang,et al.  Patterned PLG substrates for localized DNA delivery and directed neurite extension. , 2007, Biomaterials.

[38]  D. Carlo,et al.  Stabilization of poly-L-lysine/DNA polyplexes for in vivo gene delivery to the liver. , 1999, Biochimica et biophysica acta.

[39]  D. Mooney,et al.  Bone regeneration in a rat cranial defect with delivery of PEI-condensed plasmid DNA encoding for bone morphogenetic protein-4 (BMP-4) , 2005, Gene Therapy.

[40]  I. Zachary,et al.  Vascular Endothelial Growth Factor Gene Transfer Inhibits Neointimal Macrophage Accumulation in Hypercholesterolemic Rabbits , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[41]  M. D. Brown,et al.  Gene delivery with synthetic (non viral) carriers. , 2001, International journal of pharmaceutics.

[42]  Daniel P Nicolella,et al.  Dendritic processes of osteocytes are mechanotransducers that induce the opening of hemichannels , 2010, Proceedings of the National Academy of Sciences.

[43]  R. Levy,et al.  DNA delivery from an intravascular stent with a denatured collagen-polylactic-polyglycolic acid-controlled release coating: mechanisms of enhanced transfection , 2003, Gene Therapy.

[44]  A. Urtti,et al.  Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies. , 1999, Biochimica et biophysica acta.

[45]  M. Woodle,et al.  New amphipatic polymer-lipid conjugates forming long-circulating reticuloendothelial system-evading liposomes. , 1994, Bioconjugate chemistry.

[46]  F. Szoka,et al.  Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes. , 1999, Human gene therapy.

[47]  J. Hadgraft,et al.  Gene expression in an intact ex-vivo skin tissue model following percutaneous delivery of cationic liposome-plasmid DNA complexes. , 2000, International journal of pharmaceutics.

[48]  H. Blau,et al.  Myoblast‐mediated gene transfer for therapeutic angiogenesis and arteriogenesis , 2003, British journal of pharmacology.

[49]  K. Ulbrich,et al.  A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression , 2000, Gene Therapy.

[50]  D. Putnam,et al.  PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization. , 1999, Journal of pharmaceutical sciences.

[51]  H. Greisler,et al.  Modulation of vascular cell growth kinetics by local cytokine delivery from fibrin glue suspensions. , 1999, Journal of vascular surgery.

[52]  Gregg W Stone,et al.  A polymer-based, paclitaxel-eluting stent in patients with coronary artery disease. , 2004, The New England journal of medicine.

[53]  G. Acsadi,et al.  Conditions affecting direct gene transfer into rodent muscle in vivo. , 1991, BioTechniques.

[54]  C. Betsholtz,et al.  Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. , 1999, Development.

[55]  M. L. La Rotonda,et al.  Poly(lactide-co-glycolide) microspheres for the controlled release of oligonucleotide/polyethylenimine complexes. , 2002, Journal of pharmaceutical sciences.

[56]  D. Kniss,et al.  Three-dimensional cell-scaffold constructs promote efficient gene transfection: implications for cell-based gene therapy. , 2001, Tissue engineering.

[57]  A. Miller,et al.  Gene delivery and expression mediated by an integrin-binding peptide. , 1995, Gene therapy.

[58]  Hassan Adwan,et al.  Delivery and expression of pDNA embedded in collagen matrices. , 2004, Journal of controlled release : official journal of the Controlled Release Society.

[59]  A. Mikos,et al.  Poly(ethylenimine) and its role in gene delivery. , 1999, Journal of controlled release : official journal of the Controlled Release Society.

[60]  R. Macdonald,et al.  Diquaternary ammonium compounds as transfection agents. , 2001, Bioconjugate chemistry.

[61]  H. Herweijer,et al.  Progress and prospects: naked DNA gene transfer and therapy , 2003, Gene Therapy.

[62]  C. Sirlin,et al.  Gene transfer with a series of lipophilic DNA-binding molecules. , 1994, Bioconjugate chemistry.

[63]  T. Haas,et al.  Evolving strategies in manipulating VEGF/VEGFR signaling for the promotion of angiogenesis in ischemic muscle. , 2009, Current pharmaceutical design.

[64]  Jing Zhou,et al.  Endothelial Cilia Are Fluid Shear Sensors That Regulate Calcium Signaling and Nitric Oxide Production Through Polycystin-1 , 2008, Circulation.

[65]  A. Pannier,et al.  Substrate-mediated delivery from self-assembled monolayers: effect of surface ionization, hydrophilicity, and patterning. , 2005, Acta biomaterialia.

[66]  J. Hartikainen,et al.  Catheter-mediated vascular endothelial growth factor gene transfer to human coronary arteries after angioplasty. , 2000, Human gene therapy.

[67]  E. Edelman,et al.  Perivascular and intravenous administration of basic fibroblast growth factor: vascular and solid organ deposition. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[68]  N A Peppas,et al.  New challenges in biomaterials. , 1994, Science.

[69]  A. Singer,et al.  Cutaneous wound healing. , 1999, The New England journal of medicine.

[70]  David J. Mooney,et al.  Tissue engineering using synthetic extracellular matrices , 1996, Nature Medicine.

[71]  E. Wolf,et al.  CARP, a cardiac ankyrin repeat protein, is up-regulated during wound healing and induces angiogenesis in experimental granulation tissue. , 2005, The American journal of pathology.

[72]  Jae‐Hyung Jang,et al.  Surface adsorption of DNA to tissue engineering scaffolds for efficient gene delivery. , 2006, Journal of biomedical materials research. Part A.

[73]  A. George,et al.  Effect of vectors on human endothelial cell signal transduction: implications for cardiovascular gene therapy. , 2006, Arteriosclerosis, thrombosis, and vascular biology.

[74]  G. Acsadi,et al.  Direct gene transfer into mouse muscle in vivo. , 1990, Science.

[75]  R. Levine,et al.  New Efficient Catheter-Based System for Myocardial Gene Delivery , 2002, Circulation.

[76]  J. Hubbell,et al.  The role of actively released fibrin-conjugated VEGF for VEGF receptor 2 gene activation and the enhancement of angiogenesis. , 2008, Biomaterials.

[77]  A. Klibanov,et al.  Protein stability in controlled-release systems , 2000, Nature Biotechnology.

[78]  R. Malone,et al.  Structural and functional analysis of cationic transfection lipids: the hydrophobic domain. , 1996, Gene therapy.

[79]  J. Isner,et al.  Prospects for site-specific delivery of pharmacologic and molecular therapies. , 1994, Journal of the American College of Cardiology.

[80]  M. Ogris,et al.  PEGylated DNA/transferrin–PEI complexes: reduced interaction with blood components, extended circulation in blood and potential for systemic gene delivery , 1999, Gene Therapy.

[81]  G. Mclachlan,et al.  Evidence for safety and efficacy of DOTAP cationic liposome mediated CFTR gene transfer to the nasal epithelium of patients with cystic fibrosis , 1997, Gene Therapy.

[82]  David J. Mooney,et al.  DNA delivery from polymer matrices for tissue engineering , 1999, Nature Biotechnology.

[83]  R. Langer,et al.  A theoretical model of erosion and macromolecular drug release from biodegrading microspheres. , 1997, Journal of pharmaceutical sciences.

[84]  K. Hirschi,et al.  Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact. , 1999, Circulation research.

[85]  J Bonadio,et al.  Tissue engineering via local gene delivery: update and future prospects for enhancing the technology. , 2000, Advanced drug delivery reviews.

[86]  M. Cotten,et al.  Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus , 2000, Gene Therapy.

[87]  Tatiana Segura,et al.  Surface-tethered DNA complexes for enhanced gene delivery. , 2002, Bioconjugate chemistry.

[88]  D. M. Carlson,et al.  Gene expression following direct injection of DNA into liver. , 1994, Human gene therapy.

[89]  W. Saltzman,et al.  Gene expression and mucosal immune responses after vaginal DNA immunization in mice using a controlled delivery matrix. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[90]  R. Ross,et al.  Platelet-derived growth factor in vivo: levels, activity, and rate of clearance , 1984 .

[91]  J. C. Roberts,et al.  Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst dendrimers. , 1996, Journal of biomedical materials research.

[92]  Fred D. Ledley,et al.  Pharmaceutical Approach to Somatic Gene Therapy , 1996, Pharmaceutical Research.

[93]  S. Pun,et al.  Supramolecular assembly of cyclodextrin-based nanoparticles on solid surfaces for gene delivery. , 2006, Langmuir : the ACS journal of surfaces and colloids.

[94]  L. Shea,et al.  Fibrin hydrogels for non-viral vector delivery in vitro. , 2009, Journal of controlled release : official journal of the Controlled Release Society.

[95]  S. Simões,et al.  Sterically Stabilized pH-sensitive Liposomes , 1997, The Journal of Biological Chemistry.

[96]  J. Bonadio.  Genetic Approaches to Tissue Repair , 2002, Annals of the New York Academy of Sciences.

[97]  M. Kirschner,et al.  An approach to increased polyplex gene delivery by peptides selected from a phage display library. , 2002, Journal of biochemical and biophysical methods.

[98]  Jeffrey Bonadio,et al.  Localized, direct plasmid gene delivery in vivo: prolonged therapy results in reproducible tissue regeneration , 1999, Nature Medicine.

[99]  J. Hagstrom,et al.  pH-sensitive, cationic liposomes: A new synthetic virus-like vector , 1996, Nature Biotechnology.

[100]  Weiliam Chen,et al.  Hyaluronan microspheres for sustained gene delivery and site-specific targeting. , 2004, Biomaterials.

[101]  D F P Larkin,et al.  Antibody targeted gene transfer to endothelium , 2003, The journal of gene medicine.

[102]  F. Sellke,et al.  Gene transfer to induce angiogenesis in myocardial and limb ischaemia , 2001, Expert opinion on biological therapy.

[103]  J. A. Hubbell,et al.  Cell‐Responsive Synthetic Hydrogels , 2003 .

[104]  Andrés J. García,et al.  Biomaterial-mediated retroviral gene transfer using self-assembled monolayers. , 2007, Biomaterials.

[105]  W. Saltzman.  Delivering tissue regeneration , 1999, Nature Biotechnology.

[106]  L. M. Sanders,et al.  Prolonged controlled-release of nafarelin, a luteinizing hormone-releasing hormone analogue, from biodegradable polymeric implants: influence of composition and molecular weight of polymer. , 1986, Journal of pharmaceutical sciences.

[107]  R. Scheule,et al.  Development of catheter-based procedures for transducing the isolated rabbit liver with plasmid DNA. , 2002, Human gene therapy.

[108]  A. Klibanov,et al.  Non-viral gene therapy: polycation-mediated DNA delivery , 2003, Applied Microbiology and Biotechnology.

[109]  Paul Martin,et al.  Wound Healing--Aiming for Perfect Skin Regeneration , 1997, Science.

[110]  R. Levy,et al.  Gene delivery from a DNA controlled-release stent in porcine coronary arteries , 2000, Nature Biotechnology.

[111]  P. Cullis,et al.  Recent advances in liposome technologies and their applications for systemic gene delivery. , 1998, Advanced drug delivery reviews.

[112]  Y. Capan,et al.  Stability of poly(L-lysine)-complexed plasmid DNA during mechanical stress and DNase I treatment. , 1999, Pharmaceutical development and technology.

[113]  Ron Y Kwon,et al.  Primary cilia mediate mechanosensing in bone cells by a calcium-independent mechanism , 2007, Proceedings of the National Academy of Sciences.

[114]  Y. Mély,et al.  Role of endocytosis in the transfection of L929 fibroblasts by polyethylenimine/DNA complexes. , 2001, Biochimica et biophysica acta.

[115]  R. Proctor.  Fibronectin: a brief overview of its structure, function, and physiology. , 1987, Reviews of infectious diseases.

[116]  J. Baker,et al.  DNA/dendrimer complexes mediate gene transfer into murine cardiac transplants ex vivo. , 2000, Molecular therapy : the journal of the American Society of Gene Therapy.

[117]  A. Mathur,et al.  Regulation and guidance of cell behavior for tissue regeneration via the siRNA mechanism , 2007, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[118]  D. Hoekstra,et al.  Cationic lipids, lipoplexes and intracellular delivery of genes. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[119]  J. Hubbell,et al.  Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering , 2005, Nature Biotechnology.

[120]  F. Szoka,et al.  Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. , 1993, Bioconjugate chemistry.

[121]  I. Zuhorn,et al.  Gene delivery by cationic lipids: in and out of an endosome. , 2007, Biochemical Society transactions.

[122]  W. Mark Saltzman,et al.  Building drug delivery into tissue engineering design , 2002, Nature Reviews Drug Discovery.

[123]  J. Harborth,et al.  RNAi therapeutics: an update on delivery. , 2008, Current opinion in molecular therapeutics.

[124]  J. Keski‐Oja,et al.  Localization of viral-envelope-glycoprotein-binding sites in fibronectin. , 1984, The Biochemical journal.

[125]  F. Szoka,et al.  Robust and prolonged gene expression from injectable polymeric implants , 2002, Gene Therapy.

[126]  D. Lauffenburger,et al.  Targeted synthetic gene delivery vectors. , 2000, Current opinion in molecular therapeutics.

[127]  B. O’Malley,et al.  In vivo gene transfer into rabbit thyroid follicular cells by direct DNA injection. , 1994, Human gene therapy.

[128]  M. Hallek,et al.  Targeted Gene Delivery to Vascular Tissue In Vivo by Tropism-Modified Adeno-Associated Virus Vectors , 2004, Circulation.

[129]  W. Mark Saltzman,et al.  Enhancement of transfection by physical concentration of DNA at the cell surface , 2000, Nature Biotechnology.

[130]  L. Shea,et al.  Gene Delivery by Immobilization to Cell-Adhesive Substrates , 2005, MRS bulletin.

[131]  S. J. White,et al.  Selective targeting of gene transfer to vascular endothelial cells by use of peptides isolated by phage display. , 2000, Circulation.

[132]  Nancy Boudreau,et al.  HOXA3 induces cell migration in endothelial and epithelial cells promoting angiogenesis and wound repair , 2005, Journal of Cell Science.

[133]  Leaf Huang,et al.  Lipidic vector systems for gene transfer. , 1997, Critical reviews in therapeutic drug carrier systems.

[134]  D. Schaffert,et al.  Gene therapy progress and prospects: synthetic polymer-based systems , 2008, Gene Therapy.

[135]  A. Pandit,et al.  Fibrin-lipoplex system for controlled topical delivery of multiple genes. , 2009, Biomacromolecules.

[136]  L. Barrett,et al.  Factors affecting blood clearance and in vivo distribution of polyelectrolyte complexes for gene delivery , 1999, Gene Therapy.

[137]  Mark Saltzman W,et al.  Materials for protein delivery in tissue engineering. , 1998, Advanced drug delivery reviews.

[138]  Y. Jang,et al.  Inhibitory effect of the salmosin gene transferred by cationic liposomes on the progression of B16BL6 tumors. , 2003, Cancer research.

[139]  Jeffrey W Moses,et al.  Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. , 2003, The New England journal of medicine.

[140]  Takao Hayakawa,et al.  Quantitative comparison of intracellular trafficking and nuclear transcription between adenoviral and lipoplex systems. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[141]  D. Putnam,et al.  Polymer systems for gene delivery - Past, present, and future , 2007 .

[142]  V. Torchilin.  Recent advances with liposomes as pharmaceutical carriers , 2005, Nature Reviews Drug Discovery.

[143]  T. Skalak,et al.  Vascular Assembly in Natural and Engineered Tissues , 2002, Annals of the New York Academy of Sciences.

[144]  R. Hendel,et al.  Phase 1/2 Placebo-Controlled, Double-Blind, Dose-Escalating Trial of Myocardial Vascular Endothelial Growth Factor 2 Gene Transfer by Catheter Delivery in Patients With Chronic Myocardial Ischemia , 2002, Circulation.

[145]  D. Rifkin,et al.  Cell signaling events: a view from the matrix. , 2003, Matrix biology : journal of the International Society for Matrix Biology.

[146]  R. Levy,et al.  Localized adenovirus gene delivery using antiviral IgG complexation , 2001, Gene Therapy.

[147]  T. Ochiya,et al.  Biomaterials for gene delivery: atelocollagen-mediated controlled release of molecular medicines. , 2001, Current gene therapy.

[148]  G. Yancopoulos,et al.  Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, angiopoietins, and ephrins in vascular development. , 1999, Genes & development.

[149]  C. Culmsee,et al.  Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer , 2004, The journal of gene medicine.

[150]  K. Yip,et al.  Controlled release of plasmid DNA , 1997 .

[151]  M. Herlyn,et al.  Matrix immobilization enhances the tissue repair activity of growth factor gene therapy vectors. , 2001, Human gene therapy.

[152]  S. Carotta,et al.  DNA/polyethylenimine transfection particles: Influence of ligands, polymer size, and PEGylation on internalization and gene expression , 2001, AAPS PharmSci.

[153]  R. Langer,et al.  Drug delivery and targeting. , 1998, Nature.

[154]  L. Barrett,et al.  Sustained Effects of Gene-Activated Matrices after CNS Injury , 2001, Molecular and Cellular Neuroscience.

[155]  K. Webster,et al.  The effect of the controlled release of basic fibroblast growth factor from ionic gelatin-based hydrogels on angiogenesis in a murine critical limb ischemic model. , 2007, Biomaterials.

[156]  P. Hornsby,et al.  Transfection of Cells Mediated by Biodegradable Polymer Materials with Surface‐Bound Polyethyleneimine , 2000, Biotechnology progress.