Comparison of the biocompatibility of calcium silicate-based materials to mineral trioxide aggregate: Systematic review

ABSTRACT The objective of this systematic review was to evaluate the biocompatibility and interaction of bioceramic materials with animal and human mesenchymal cells in vitro and in vivo and to compare them with mineral trioxide aggregate (MTA). Two independent researchers conducted PubMed/Medline, Web of Science, and Scopus searches to identify studies published in English, without restrictions on year of publication using the following keywords: “root canal sealer,” “root repair material,” “cytotoxicity,” and “bioceramics.” The articles were selected following the PRISMA statement. A total of 1486 titles were identified in the initial search. However, only 18 studies met the inclusion and exclusion criteria. The results showed that bioceramic materials have biological properties similar to those of MTA, including low cytotoxicity as well as promoting cell proliferation and adhesion, low expression of inflammatory cytokines, and reduced pulp inflammation. This systematic review therefore suggests that the choice of repair bioceramic materials or MTA based on biocompatibility should be the professional's decision.

[1]  B. Peng,et al.  Evaluation of the in vitro biocompatibility of a new fast‐setting ready‐to‐use root filling and repair material , 2017, International endodontic journal.

[2]  Hisham S Rifaey,et al.  Comparison of the Osteogenic Potential of Mineral Trioxide Aggregate and Endosequence Root Repair Material in a 3-dimensional Culture System. , 2016, Journal of endodontics.

[3]  F. Setzer,et al.  A New Calcium Silicate-based Bioceramic Material Promotes Human Osteo- and Odontogenic Stem Cell Proliferation and Survival via the Extracellular Signal-regulated Kinase Signaling Pathway. , 2016, Journal of endodontics.

[4]  A. Vaisberg,et al.  In Vitro Cytotoxicity Evaluation of Three Root-End Filling Materials in Human Periodontal Ligament Fibroblasts. , 2016, Brazilian dental journal.

[5]  S. K. Abunasef,et al.  Can Mineral Trioxide Aggregate and Nanoparticulate EndoSequence Root Repair Material Produce Injurious Effects to Rat Subcutaneous Tissues? , 2015, Journal of endodontics.

[6]  K. Ranganathan,et al.  Cytotoxicity evaluation of root repair materials in human-cultured periodontal ligament fibroblasts , 2014, Journal of conservative dentistry : JCD.

[7]  V. Kojić,et al.  Biocompatibility of Three Root End Filling Materials , 2014 .

[8]  H. Bosomworth,et al.  Biodentine and mineral trioxide aggregate induce similar cellular responses in a fibroblast cell line. , 2014, Journal of endodontics.

[9]  Yuan Gao,et al.  A Comparative Study on Root Canal Repair Materials: A Cytocompatibility Assessment in L929 and MG63 Cells , 2014, TheScientificWorldJournal.

[10]  F. Şahin,et al.  In vitro comparison of induction capacity and biomineralization ability of mineral trioxide aggregate and a bioceramic root canal sealer. , 2013, International endodontic journal.

[11]  M. Fan,et al.  BioAggregate and iRoot BP Plus optimize the proliferation and mineralization ability of human dental pulp cells. , 2013, International endodontic journal.

[12]  B. Willershausen,et al.  Influence of a bioceramic root end material and mineral trioxide aggregates on fibroblasts and osteoblasts. , 2013, Archives of oral biology.

[13]  Ya Shen,et al.  In vitro cytotoxicity evaluation of a novel root repair material. , 2013, Journal of endodontics.

[14]  D. Tipton,et al.  Cytotoxicity and alkaline phosphatase activity evaluation of endosequence root repair material. , 2012, Journal of endodontics.

[15]  J. Granjeiro,et al.  Cytocompatibility of the ready-to-use bioceramic putty repair cement iRoot BP Plus with primary human osteoblasts. , 2012, International endodontic journal.

[16]  T. Montagnese,et al.  A comparison of the cytotoxicity and proinflammatory cytokine production of EndoSequence root repair material and ProRoot mineral trioxide aggregate in human osteoblast cell culture using reverse-transcriptase polymerase chain reaction. , 2012, Journal of endodontics.

[17]  M. Wheater,et al.  Cytotoxicity comparison of three current direct pulp-capping agents with a new bioceramic root repair putty. , 2012, Journal of endodontics.

[18]  Ya Shen,et al.  Biocompatibility of two novel root repair materials. , 2011, Journal of endodontics.

[19]  J. Marshall,et al.  Comparison of intracanal EndoSequence Root Repair Material and ProRoot MTA to induce pH changes in simulated root resorption defects over 4 weeks in matched pairs of human teeth. , 2011, Journal of endodontics.

[20]  M. Wheater,et al.  Cytotoxicity comparison of mineral trioxide aggregates and EndoSequence bioceramic root repair materials. , 2011, Journal of endodontics.

[21]  C. Kao,et al.  Expression of the inflammatory marker cyclooxygenase-2 in dental pulp cells cultured with mineral trioxide aggregate or calcium silicate cements. , 2010, Journal of endodontics.

[22]  Jin Jiang,et al.  Cytotoxicity evaluation of endosequence root repair material. , 2010, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[23]  L. Ye,et al.  Cytotoxicity of RealSeal on human osteoblast-like MG63 cells. , 2010, Journal of endodontics.

[24]  B. Peng,et al.  Assessment of a new root canal sealer's apical sealing ability. , 2009, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[25]  N. Chandler,et al.  Calcium hydroxide-based root canal sealers: a review. , 2009, Journal of endodontics.

[26]  P. Roach,et al.  Modern biomaterials: a review—bulk properties and implications of surface modifications , 2007, Journal of materials science. Materials in medicine.

[27]  A. Curtis,et al.  The influence of microscale topography on fibroblast attachment and motility. , 2004, Biomaterials.

[28]  J. Camilleri,et al.  Biocompatibility of two commercial forms of mineral trioxide aggregate. , 2004, International endodontic journal.

[29]  J. Szabó,et al.  Tissue reaction initiated by different sealers. , 2003, International endodontic journal.