International Union of Pharmacology. LV. Nomenclature and Molecular Relationships of Two-P Potassium Channels

In less than a decade since their discovery, the study of K2P channels has revealed that background leak of potassium ions via dedicated pathways is a highly regulated mechanism to control cellular excitability. Potassium leak pathways, active at rest, stabilize membrane potential below firing

[1]  Donghee Kim,et al.  Synergistic interaction and the role of C-terminus in the activation of TRAAK K+ channels by pressure, free fatty acids and alkali , 2001, Pflügers Archiv.

[2]  M. Lazdunski,et al.  Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels. , 2001, Biochemical and biophysical research communications.

[3]  M. Lazdunski,et al.  A TREK-1-Like Potassium Channel in Atrial Cells Inhibited by &bgr;-Adrenergic Stimulation and Activated by Volatile Anesthetics , 2001, Circulation research.

[4]  P. Stanfield,et al.  TASK-5, a novel member of the tandem pore K+ channel family , 2001, Pflügers Archiv.

[5]  S. Goldstein,et al.  ORK1, a potassium-selective leak channel with two pore domains cloned from Drosophila melanogaster by expression in Saccharomyces cerevisiae. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[6]  J. Barhanin,et al.  Role of TASK2 Potassium Channels Regarding Volume Regulation in Primary Cultures of Mouse Proximal Tubules , 2003, The Journal of general physiology.

[7]  Donghee Kim,et al.  TASK-3, a New Member of the Tandem Pore K+ Channel Family* , 2000, The Journal of Biological Chemistry.

[8]  M. Lazdunski,et al.  TASK, a human background K+ channel to sense external pH variations near physiological pH , 1997, The EMBO journal.

[9]  Miguel Salinas,et al.  Cloning and Expression of a Novel pH-sensitive Two Pore Domain K+ Channel from Human Kidney* , 1998, The Journal of Biological Chemistry.

[10]  M. Lazdunski,et al.  ARF6‐dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6 , 2004, EMBO reports.

[11]  A. Gray,et al.  TWIK-2, a New Weak Inward Rectifying Member of the Tandem Pore Domain Potassium Channel Family* , 1999, The Journal of Biological Chemistry.

[12]  A. Karschin,et al.  TASK-3, a Novel Tandem Pore Domain Acid-sensitive K+Channel , 2000, The Journal of Biological Chemistry.

[13]  E. Honoré,et al.  The lipid‐activated two‐pore domain K+ channel TREK‐1 is resistant to hypoxia: implication for ischaemic neuroprotection , 2005, The Journal of physiology.

[14]  D. Ward,et al.  Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels. , 2000, Gene.

[15]  M. Lazdunski,et al.  Cloning and expression of human TRAAK, a polyunsaturated fatty acids‐activated and mechano‐sensitive K+ channel , 2000, FEBS letters.

[16]  M. Lazdunski,et al.  TREK‐1, a K+ channel involved in neuroprotection and general anesthesia , 2004, The EMBO journal.

[17]  C. D. Benham,et al.  Cloning, localisation and functional expression of the human orthologue of the TREK-1 potassium channel , 2000, Pflügers Archiv.

[18]  F. Lesage,et al.  TASK (TWIK-related acid-sensitive K+ channel) is expressed in glomerulosa cells of rat adrenal cortex and inhibited by angiotensin II. , 2000, Molecular endocrinology.

[19]  M. Lazdunski,et al.  Molecular and functional properties of two-pore-domain potassium channels. , 2000, American journal of physiology. Renal physiology.

[20]  L. Barros,et al.  Modulation of the Two-pore Domain Acid-sensitive K+ Channel TASK-2 (KCNK5) by Changes in Cell Volume* , 2001, The Journal of Biological Chemistry.

[21]  A. Gray,et al.  Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem. , 1999, Anesthesiology.

[22]  A. Karschin,et al.  Expression pattern and functional characteristics of two novel splice variants of the two‐pore‐domain potassium channel TREK‐2 , 2002, The Journal of physiology.

[23]  M. Pausch,et al.  Sequence and function of the two P domain potassium channels: implications of an emerging superfamily , 1997, Journal of Molecular Medicine.

[24]  S. Goldstein,et al.  K2P channels and their protein partners , 2005, Current Opinion in Neurobiology.

[25]  Y. Horio,et al.  Cloning and functional expression of a novel cardiac two-pore background K+ channel (cTBAK-1). , 1998, Circulation research.

[26]  D. Bockenhauer,et al.  KCNK2: reversible conversion of a hippocampal potassium leak into a voltage-dependent channel , 2001, Nature Neuroscience.

[27]  M. Wigler,et al.  Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. , 2003, Cancer cell.

[28]  L. Jan,et al.  Oncogenic potential of TASK3 (Kcnk9) depends on K+ channel function , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[29]  Edmund M Talley,et al.  TASK-1, a Two–Pore Domain K+ Channel, Is Modulated by Multiple Neurotransmitters in Motoneurons , 2000, Neuron.

[30]  Joseph F. Cotten,et al.  Potent Activation of the Human Tandem Pore Domain K Channel TRESK with Clinical Concentrations of Volatile Anesthetics , 2004, Anesthesia and analgesia.

[31]  Donghee Kim,et al.  Characterization of four types of background potassium channels in rat cerebellar granule neurons , 2002, The Journal of physiology.

[32]  M. Lazdunski,et al.  The endocannabinoid anandamide is a direct and selective blocker of the background K+ channel TASK‐1 , 2001, The EMBO journal.

[33]  P. Meneton,et al.  Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Donghee Kim,et al.  Functional Expression of TRESK-2, a New Member of the Tandem-pore K+ Channel Family* , 2004, Journal of Biological Chemistry.

[35]  A. Patel,et al.  The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK. , 2000, Molecular pharmacology.

[36]  M. Butler,et al.  Proton Block and Voltage Gating Are Potassium-dependent in the Cardiac Leak Channel Kcnk3* , 2000, The Journal of Biological Chemistry.

[37]  Donghee Kim,et al.  Functional expression of TREK-2 in insulin-secreting MIN6 cells. , 2004, Biochemical and biophysical research communications.

[38]  M. Lazdunski,et al.  TWIK‐1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. , 1996, The EMBO journal.

[39]  Donghee Kim,et al.  TASK-5, a new member of the tandem-pore K(+) channel family. , 2001, Biochemical and biophysical research communications.

[40]  Donghee Kim,et al.  TREK-2, a New Member of the Mechanosensitive Tandem-pore K+ Channel Family* , 2000, The Journal of Biological Chemistry.

[41]  M. Lazdunski,et al.  The structure, function and distribution of the mouse TWIK‐1 K+ channel , 1997, FEBS letters.

[42]  A. Karschin,et al.  Interaction with 14‐3‐3 proteins promotes functional expression of the potassium channels TASK‐1 and TASK‐3 , 2002, The Journal of physiology.

[43]  P. Murdock,et al.  Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel. , 2000, Brain research. Molecular brain research.

[44]  M. Lazdunski,et al.  Lysophospholipids Open the Two-pore Domain Mechano-gated K+ Channels TREK-1 and TRAAK* , 2000, The Journal of Biological Chemistry.

[45]  A. Gray,et al.  Assignment1 of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping , 1999, Cytogenetic and Genome Research.

[46]  M. Lazdunski,et al.  Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43. , 1996, Genomics.

[47]  Donghee Kim,et al.  Functional expression of TREK-2 K+ channel in cultured rat brain astrocytes , 2002, Brain Research.

[48]  Kohei Inamura,et al.  A Novel Two-pore Domain K+ Channel, TRESK, Is Localized in the Spinal Cord* , 2003, Journal of Biological Chemistry.

[49]  M. Lazdunski,et al.  A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids , 1998, The EMBO journal.

[50]  Donghee Kim,et al.  Thermosensitivity of the two‐pore domain K+ channels TREK‐2 and TRAAK , 2005, The Journal of physiology.

[51]  I. O'kelly,et al.  Forward Transport 14-3-3 Binding Overcomes Retention in Endoplasmic Reticulum by Dibasic Signals , 2002, Cell.

[52]  M. Lazdunski,et al.  p11, an annexin II subunit, an auxiliary protein associated with the background K+ channel, TASK‐1 , 2002, The EMBO journal.

[53]  M. Lazdunski,et al.  Pancreatic two P domain K+ channels TALK‐1 and TALK‐2 are activated by nitric oxide and reactive oxygen species , 2005, The Journal of physiology.

[54]  M. Lazdunski,et al.  TRAAK Is a Mammalian Neuronal Mechano-gated K+Channel* , 1999, The Journal of Biological Chemistry.

[55]  A. Gray,et al.  An Open Rectifier Potassium Channel with Two Pore Domains in Tandem Cloned from Rat Cerebellum , 1998, The Journal of Neuroscience.

[56]  G. Czirják,et al.  Ruthenium red inhibits TASK-3 potassium channel by interconnecting glutamate 70 of the two subunits. , 2003, Molecular pharmacology.

[57]  Donghee Kim,et al.  TBAK-1 and TASK-1, two-pore K+ channel subunits: kinetic properties and expression in rat heart. , 1999, American journal of physiology. Heart and circulatory physiology.

[58]  A. Gray,et al.  Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping. , 1999, Cytogenetics and cell genetics.

[59]  M. Lazdunski,et al.  TWIK-2, an Inactivating 2P Domain K+ Channel* , 2000, The Journal of Biological Chemistry.

[60]  M. Lazdunski,et al.  Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. , 1996, The EMBO journal.

[61]  C. Sladek,et al.  Background and tandem‐pore potassium channels in magnocellular neurosecretory cells of the rat supraoptic nucleus , 2003, The Journal of physiology.

[62]  Z. Tóth,et al.  The Two-pore Domain K+ Channel, TRESK, Is Activated by the Cytoplasmic Calcium Signal through Calcineurin* , 2004, Journal of Biological Chemistry.

[63]  M. Lazdunski,et al.  Immunolocalization of the arachidonic acid and mechanosensitive baseline TRAAK potassium channel in the nervous system , 1999, Neuroscience.

[64]  P. Bray-Ward,et al.  Assignment1 of the 2P domain, acid-sensitive potassium channel OAT1 gene KCNK3 to human chromosome bands 2p24.1→p23.3 and murine 5B by in situ hybridization , 1999, Cytogenetic and Genome Research.

[65]  G. Desir,et al.  Cloning and localization of a double-pore K channel, KCNK1: exclusive expression in distal nephron segments. , 1997, American journal of physiology. Renal physiology.

[66]  Donghee Kim,et al.  Single-channel properties and pH sensitivity of two-pore domain K+ channels of the TALK family. , 2004, Biochemical and biophysical research communications.

[67]  D. Bayliss,et al.  The TASK-1 Two-Pore Domain K+ Channel Is a Molecular Substrate for Neuronal Effects of Inhalation Anesthetics , 2000, The Journal of Neuroscience.

[68]  Sami H. Jezzini,et al.  Identification and distribution of a two-pore domain potassium channel in the CNS of Aplysia californica. , 2004, Brain research. Molecular brain research.

[69]  Donghee Kim,et al.  Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1. , 2003, American journal of physiology. Cell physiology.

[70]  E. Honoré,et al.  An oxygen‐, acid‐ and anaesthetic‐sensitive TASK‐like background potassium channel in rat arterial chemoreceptor cells , 2000, The Journal of physiology.

[71]  B. Rudy,et al.  Identification and cloning of TWIK‐originated similarity sequence (TOSS): a novel human 2‐pore K+ channel principal subunit , 1999, FEBS letters.

[72]  M. Niemeyer,et al.  Extracellular conserved cysteine forms an intersubunit disulphide bridge in the KCNK5 (TASK-2) K + channel without having an essential effect upon activity , 2003, Molecular membrane biology.

[73]  M. Hunter,et al.  Na(+)-induced inward rectification in the two-pore domain K(+) channel, TASK-2. , 2005, American journal of physiology. Renal physiology.

[74]  J. Gassenhuber,et al.  Characterization of TASK‐4, a novel member of the pH‐sensitive, two‐pore domain potassium channel family , 2001, FEBS letters.

[75]  Detlef Bockenhauer,et al.  Potassium leak channels and the KCNK family of two-p-domain subunits , 2001, Nature Reviews Neuroscience.

[76]  M. Lazdunski,et al.  TREK‐1 is a heat‐activated background K+ channel , 2000, The EMBO journal.

[77]  A. Patel,et al.  Mechano- or Acid Stimulation, Two Interactive Modes of Activation of the TREK-1 Potassium Channel* , 1999, The Journal of Biological Chemistry.

[78]  M. Lazdunski,et al.  K+-dependent Cerebellar Granule Neuron Apoptosis , 2003, Journal of Biological Chemistry.

[79]  M. Lazdunski,et al.  Cloning of a New Mouse Two-P Domain Channel Subunit and a Human Homologue with a Unique Pore Structure* , 1999, The Journal of Biological Chemistry.

[80]  B. Robertson,et al.  A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[81]  Edmund M Talley,et al.  Serotonergic Raphe Neurons Express TASK Channel Transcripts and a TASK-Like pH- and Halothane-Sensitive K+ Conductance , 2002, The Journal of Neuroscience.

[82]  D. Bayliss,et al.  Functional expression of TASK‐1/TASK‐3 heteromers in cerebellar granule cells , 2004, The Journal of physiology.

[83]  Leonard K. Kaczmarek,et al.  A new family of outwardly rectifying potassium channel proteins with two pore domains in tandem , 1995, Nature.

[84]  M. Lazdunski,et al.  Human TREK2, a 2P Domain Mechano-sensitive K+Channel with Multiple Regulations by Polyunsaturated Fatty Acids, Lysophospholipids, and Gs, Gi, and Gq Protein-coupled Receptors* , 2000, The Journal of Biological Chemistry.

[85]  C. Kindler,et al.  Localization of the tandem pore domain K+ channel KCNK5 (TASK-2) in the rat central nervous system. , 2000, Brain research. Molecular brain research.

[86]  A. Gray,et al.  Volatile Anesthetics Activate the Human Tandem Pore Domain Baseline K+ Channel KCNK5 , 2000, Anesthesiology.

[87]  M. Butler,et al.  Sumoylation Silences the Plasma Membrane Leak K+ Channel K2P1 , 2005, Cell.

[88]  K. Grzeschik,et al.  THIK-1 and THIK-2, a Novel Subfamily of Tandem Pore Domain K+ Channels* 210 , 2001, The Journal of Biological Chemistry.

[89]  M. Lazdunski,et al.  Inhalational anesthetics activate two-pore-domain background K+ channels , 1999, Nature Neuroscience.

[90]  B. Rudy,et al.  KT3.2 and KT3.3, two novel human two-pore K(+) channels closely related to TASK-1. , 2001, Journal of neurophysiology.