Deep phenotyping unveils hidden traits and genetic relations in subtle mutants
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Matthew M. Crane | Patrick T. McGrath | Hang Lu | Peri T Kurshan | K. Shen | A. San-Miguel | Yuehui Zhao | Adriana San-Miguel | Peri T. Kurshan
[1] Mason Klein,et al. Pan-neuronal imaging in roaming Caenorhabditis elegans , 2015, Proceedings of the National Academy of Sciences.
[2] M. Boutros,et al. Microscopy-Based High-Content Screening , 2015, Cell.
[3] Wolfgang Huber,et al. A chemical–genetic interaction map of small molecules using high‐throughput imaging in cancer cells , 2015, Molecular systems biology.
[4] Lani F. Wu,et al. The Developmental Rules of Neural Superposition in Drosophila , 2015, Cell.
[5] J. Bessereau,et al. C. elegans Punctin Clusters GABAA Receptors via Neuroligin Binding and UNC-40/DCC Recruitment , 2015, Neuron.
[6] L. Kruglyak,et al. The role of regulatory variation in complex traits and disease , 2015, Nature Reviews Genetics.
[7] Randall T Peterson,et al. 15 years of zebrafish chemical screening. , 2015, Current opinion in chemical biology.
[8] Laura M. Jackson,et al. Finding Our Way through Phenotypes , 2015, PLoS biology.
[9] K. Shen,et al. MTM-6, a Phosphoinositide Phosphatase, is Required to Promote Synapse Formation in Caenorhabditis elegans , 2014, PloS one.
[10] Dimitris N. Metaxas,et al. CeleST: Computer Vision Software for Quantitative Analysis of C. elegans Swim Behavior Reveals Novel Features of Locomotion , 2014, PLoS Comput. Biol..
[11] Michelle R. Arkin,et al. Screening for noise in gene expression identifies drug synergies , 2014, Science.
[12] Takamasa Kudo,et al. Controlling low rates of cell differentiation through noise and ultrahigh feedback , 2014, Science.
[13] C. Granier,et al. Phenotyping and beyond: modelling the relationships between traits. , 2014, Current opinion in plant biology.
[14] E. Banks,et al. De novo mutations in schizophrenia implicate synaptic networks , 2014, Nature.
[15] Z. Bao,et al. De Novo Inference of Systems-Level Mechanistic Models of Development from Live-Imaging-Based Phenotype Analysis , 2014, Cell.
[16] Sangsub Jung,et al. QuantWorm: A Comprehensive Software Package for Caenorhabditis elegans Phenotypic Assays , 2014, PloS one.
[17] A. Oudenaarden,et al. Feedback Control of Gene Expression Variability in the Caenorhabditis elegans Wnt Pathway , 2013, Cell.
[18] Hang Lu,et al. Microfluidics as a tool for C. elegans research. , 2013, WormBook : the online review of C. elegans biology.
[19] K. Shen,et al. The Balance between Capture and Dissociation of Presynaptic Proteins Controls the Spatial Distribution of Synapses , 2013, Neuron.
[20] Stephen T. C. Wong,et al. A Screen for Morphological Complexity Identifies Regulators of Switch-like Transitions between Discrete Cell Shapes , 2013, Nature Cell Biology.
[21] Bo Xian,et al. WormFarm: a quantitative control and measurement device toward automated Caenorhabditis elegans aging analysis , 2013, Aging cell.
[22] Walter Fontana,et al. The Caenorhabditis elegans Lifespan Machine , 2013, Nature Methods.
[23] Paul R Zurek,et al. 3D phenotyping and quantitative trait locus mapping identify core regions of the rice genome controlling root architecture , 2013, Proceedings of the National Academy of Sciences.
[24] Matthew M. Crane,et al. Quantitative screening of genes regulating tryptophan hydroxylase transcription in Caenorhabditis elegans using microfluidics and an adaptive algorithm. , 2013, Integrative biology : quantitative biosciences from nano to macro.
[25] Michael E. Greenberg,et al. Activity-dependent neuronal signalling and autism spectrum disorder , 2013, Nature.
[26] James M. Rehg,et al. Autonomous screening implicates new genes in synaptogenesis of C. elegans , 2012, Nature Methods.
[27] Satwik Rajaram,et al. PhenoRipper: software for rapidly profiling microscopy images , 2012, Nature Methods.
[28] Polina Golland,et al. An image analysis toolbox for high-throughput C. elegans assays , 2012, Nature Methods.
[29] M. Tester,et al. Phenomics--technologies to relieve the phenotyping bottleneck. , 2011, Trends in plant science.
[30] Gaudenz Danuser,et al. Computer Vision in Cell Biology , 2011, Cell.
[31] Rex A. Kerr,et al. High-Throughput Behavioral Analysis in C. elegans , 2011, Nature Methods.
[32] Shigeki Watanabe,et al. CYY-1/Cyclin Y and CDK-5 Differentially Regulate Synapse Elimination and Formation for Rewiring Neural Circuits , 2011, Neuron.
[33] F. Piano,et al. A High-Resolution C. elegans Essential Gene Network Based on Phenotypic Profiling of a Complex Tissue , 2011, Cell.
[34] S. Omholt,et al. Phenomics: the next challenge , 2010, Nature Reviews Genetics.
[35] William A Fera. The next IT challenge. , 2010, Journal of AHIMA.
[36] Emily K. Lehrman,et al. An Arf-like Small G Protein, ARL-8, Promotes the Axonal Transport of Presynaptic Cargoes by Suppressing Vesicle Aggregation , 2010, Neuron.
[37] Y. Goshima,et al. Genes Required for Cellular UNC-6/Netrin Localization in Caenorhabditis elegans , 2010, Genetics.
[38] Emily K. Lehrman,et al. Two Cyclin-Dependent Kinase Pathways Are Essential for Polarized Trafficking of Presynaptic Components , 2010, Cell.
[39] Y. Kalaidzidis,et al. Systems survey of endocytosis by multiparametric image analysis , 2010, Nature.
[40] Lav R. Varshney,et al. Structural Properties of the Caenorhabditis elegans Neuronal Network , 2009, PLoS Comput. Biol..
[41] Polina Golland,et al. Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning , 2009, Proceedings of the National Academy of Sciences.
[42] Kwanghun Chung,et al. Computer-enhanced high-throughput genetic screens of C. elegans in a microfluidic system. , 2009, Lab on a chip.
[43] J. Kaplan,et al. Profiling Synaptic Proteins Identifies Regulators of Insulin Secretion and Lifespan , 2008, PLoS genetics.
[44] K. Shen,et al. UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites , 2008, Nature.
[45] Lucas Pelkmans,et al. Lessons from genetics: interpreting complex phenotypes in RNAi screens. , 2008, Current opinion in cell biology.
[46] Thomas J. Nicholas,et al. Automated analysis of embryonic gene expression with cellular resolution in C. elegans , 2008, Nature Methods.
[47] Matthew M. Crane,et al. Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans , 2008, Nature Methods.
[48] K. Shen,et al. Building a synapse: lessons on synaptic specificity and presynaptic assembly from the nematode C. elegans , 2008, Current Opinion in Neurobiology.
[49] Randy D Blakely,et al. Vigorous Motor Activity in Caenorhabditis elegans Requires Efficient Clearance of Dopamine Mediated by Synaptic Localization of the Dopamine Transporter DAT-1 , 2007, The Journal of Neuroscience.
[50] K. Shen,et al. Wnt Signaling Positions Neuromuscular Connectivity by Inhibiting Synapse Formation in C. elegans , 2007, Cell.
[51] C. Bakal,et al. Quantitative Morphological Signatures Define Local Signaling Networks Regulating Cell Morphology , 2007, Science.
[52] Lani F. Wu,et al. Image-based multivariate profiling of drug responses from single cells , 2007, Nature Methods.
[53] Maulik R. Patel,et al. Hierarchical assembly of presynaptic components in defined C. elegans synapses , 2006, Nature Neuroscience.
[54] M. Nonet,et al. SYD-2 Liprin-α organizes presynaptic active zone formation through ELKS , 2006, Nature Neuroscience.
[55] Timothy R Mahoney,et al. Analysis of synaptic transmission in Caenorhabditis elegans using an aldicarb-sensitivity assay , 2006, Nature Protocols.
[56] Anne E Carpenter,et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes , 2006, Genome Biology.
[57] R. Waterston,et al. Automated cell lineage tracing in Caenorhabditis elegans. , 2006, Proceedings of the National Academy of Sciences of the United States of America.
[58] Marc Vidal,et al. Predictive models of molecular machines involved in Caenorhabditis elegans early embryogenesis , 2005, Nature.
[59] Marc Vidal,et al. Systematic analysis of genes required for synapse structure and function , 2005, Nature.
[60] Lani F. Wu,et al. Multidimensional Drug Profiling By Automated Microscopy , 2004, Science.
[61] Cori Bargmann,et al. Mechanosensory Neurite Termination and Tiling Depend on SAX-2 and the SAX-1 Kinase , 2004, Neuron.
[62] Erik M. Jorgensen,et al. The art and design of genetic screens: Caenorhabditis elegans , 2002, Nature Reviews Genetics.
[63] M. Zhen,et al. The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans , 1999, Nature.
[64] K. Matsumoto,et al. A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type‐D GABAergic motor neurons , 1999, The EMBO journal.
[65] DH Hall,et al. The posterior nervous system of the nematode Caenorhabditis elegans: serial reconstruction of identified neurons and complete pattern of synaptic interactions , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[66] N. Munakata. [Genetics of Caenorhabditis elegans]. , 1989, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.
[67] Azriel Rosenfeld,et al. Computer Vision , 1988, Adv. Comput..
[68] S. Brenner,et al. The structure of the nervous system of the nematode Caenorhabditis elegans. , 1986, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
[69] A. I.,et al. Neural Field Continuum Limits and the Structure–Function Partitioning of Cognitive–Emotional Brain Networks , 2023, Biology.
[70] M. Labouesse. [Caenorhabditis elegans]. , 2003, Medecine sciences : M/S.
[71] Cori Bargmann,et al. The SAD-1 Kinase Regulates Presynaptic Vesicle Clustering and Axon Termination , 2001, Neuron.
[72] W. Wood. The Nematode Caenorhabditis elegans , 1988 .