TRPA1 in Drug Discovery

[1]  Z. J. Wang,et al.  Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain , 2011, Neuroscience.

[2]  D. Julius,et al.  Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli , 2011, Proceedings of the National Academy of Sciences.

[3]  Teresa L. Cvetkov,et al.  Molecular Architecture and Subunit Organization of TRPA1 Ion Channel Revealed by Electron Microscopy* , 2011, The Journal of Biological Chemistry.

[4]  T. Ryckmans,et al.  Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel. , 2011, Bioorganic & medicinal chemistry letters.

[5]  A. Page,et al.  TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity , 2011, The Journal of physiology.

[6]  J. Segreti,et al.  Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation , 2011, PAIN.

[7]  Xinzhong Dong,et al.  TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch , 2011, Nature Neuroscience.

[8]  J. Calixto,et al.  TRPA1 receptor modulation attenuates bladder overactivity induced by spinal cord injury. , 2011, American journal of physiology. Renal physiology.

[9]  A. Pertovaara,et al.  Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat , 2011, PAIN®.

[10]  A. Patapoutian,et al.  TRPA1 Contributes to Cold Hypersensitivity , 2010, The Journal of Neuroscience.

[11]  S. Yoo,et al.  Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti‐nociception , 2010, British journal of pharmacology.

[12]  Wendy M. Knowlton,et al.  TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo , 2010, PAIN.

[13]  G. Bedoya,et al.  A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome , 2010, Neuron.

[14]  P. Kym,et al.  TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats , 2010, Molecular pain.

[15]  Hongzhen Hu,et al.  Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs , 2010, Pflügers Archiv - European Journal of Physiology.

[16]  Manuela Schmidt,et al.  Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane , 2009, Neuron.

[17]  E. Carstens,et al.  Mustard oil enhances spinal neuronal responses to noxious heat but not cooling , 2009, Neuroscience Letters.

[18]  D. Shander,et al.  Non-neuronal expression of transient receptor potential type A1 (TRPA1) in human skin. , 2009, The Journal of investigative dermatology.

[19]  A. Pertovaara,et al.  Attenuation of Mechanical Hypersensitivity by an Antagonist of the TRPA1 Ion Channel in Diabetic Animals , 2009, Anesthesiology.

[20]  K. Noguchi,et al.  Transient receptor potential A1 mediates gastric distention-induced visceral pain in rats , 2009, Gut.

[21]  S. Jordt,et al.  A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma , 2009, Proceedings of the National Academy of Sciences.

[22]  S. Earley,et al.  Endothelium-Dependent Cerebral Artery Dilation Mediated by TRPA1 and Ca2+-Activated K+ Channels , 2009, Circulation research.

[23]  D. Corey,et al.  TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons , 2009, The Journal of Neuroscience.

[24]  S. Jordt,et al.  Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[25]  D. Corey,et al.  Burning Cold: Involvement of TRPA1 in Noxious Cold Sensation , 2009, The Journal of general physiology.

[26]  P. Heppenstall,et al.  TRPA1 and Cold Transduction: An Unresolved Issue? , 2009, The Journal of general physiology.

[27]  C. Stucky,et al.  Pharmacological blockade of TRPA1 inhibits mechanical firing in nociceptors , 2009, Molecular pain.

[28]  P. Geppetti,et al.  Cough: The Emerging Role of the TRPA1 Channel , 2009, Lung.

[29]  S. Jordt,et al.  Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. , 2008, Physiology.

[30]  P. Honore,et al.  Contributions of central and peripheral TRPV1 receptors to mechanically evoked and spontaneous firing of spinal neurons in inflamed rats. , 2008, Journal of neurophysiology.

[31]  D. McKemy,et al.  The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions* , 2008, Journal of Biological Chemistry.

[32]  Y. Kubo,et al.  Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels , 2008, Proceedings of the National Academy of Sciences.

[33]  A. Patapoutian,et al.  Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels , 2008, The Journal of Neuroscience.

[34]  S. Jordt,et al.  TRPA1 Mediates the Noxious Effects of Natural Sesquiterpene Deterrents* , 2008, Journal of Biological Chemistry.

[35]  N. Bunnett,et al.  Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1 , 2008, Proceedings of the National Academy of Sciences.

[36]  C. Belmonte,et al.  TRPA1 Channels Mediate Cold Temperature Sensing in Mammalian Vagal Sensory Neurons: Pharmacological and Genetic Evidence , 2008, The Journal of Neuroscience.

[37]  D. Massi,et al.  Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. , 2008, The Journal of clinical investigation.

[38]  S. Simon,et al.  How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways. , 2008, The Journal of clinical investigation.

[39]  N. Sahibzada,et al.  General anesthetics activate a nociceptive ion channel to enhance pain and inflammation , 2008, Proceedings of the National Academy of Sciences.

[40]  P. Anand,et al.  TRPA1 receptor localisation in the human peripheral nervous system and functional studies in cultured human and rat sensory neurons , 2008, Neuroscience Letters.

[41]  J. Dunham,et al.  Inflammation reduces mechanical thresholds in a population of transient receptor potential channel A1-expressing nociceptors in the rat , 2008, The European journal of neuroscience.

[42]  P. Hajduk,et al.  Molecular Determinants of Species-Specific Activation or Blockade of TRPA1 Channels , 2008, The Journal of Neuroscience.

[43]  S. Jordt,et al.  TRPA1 is a major oxidant sensor in murine airway sensory neurons. , 2008, The Journal of clinical investigation.

[44]  Hong Ao,et al.  Activation of TRPA1 by Farnesyl Thiosalicylic Acid , 2008, Molecular Pharmacology.

[45]  T. Neelands,et al.  Transient receptor potential A1 mediates an osmotically activated ion channel , 2008, The European journal of neuroscience.

[46]  D. Andersson,et al.  Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. , 2008, European urology.

[47]  E. Carstens,et al.  Effects of TRPA1 agonists mustard oil and cinnamaldehyde on lumbar spinal wide-dynamic range neuronal responses to innocuous and noxious cutaneous stimuli in rats. , 2008, Journal of neurophysiology.

[48]  D. Henze,et al.  HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity , 2008, Molecular pain.

[49]  S. Yoo,et al.  Transient receptor potential A1 mediates acetaldehyde‐evoked pain sensation , 2007, The European journal of neuroscience.

[50]  M. Takeda,et al.  Transient receptor potential channel A1 involved in sensory transduction of rat urinary bladder through C-fiber pathway. , 2007, Urology.

[51]  A. Basbaum,et al.  4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1 , 2007, Proceedings of the National Academy of Sciences.

[52]  Michael Zhao,et al.  TRPA1 mediates formalin-induced pain , 2007, Proceedings of the National Academy of Sciences.

[53]  C. van Weel,et al.  Prevalence of physical symptoms of itch, pain and fatigue in patients with skin diseases in general practice , 2007, The British journal of dermatology.

[54]  G. Gisselmann,et al.  Transient Receptor Potential Channel A1 Is Directly Gated by Calcium Ions* , 2007, Journal of Biological Chemistry.

[55]  T. Holzman,et al.  Activation of TRPA1 Channels by the Fatty Acid Amide Hydrolase Inhibitor 3′-Carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597) , 2007, Molecular Pharmacology.

[56]  M. Schaefer,et al.  TRPA1 Is Differentially Modulated by the Amphipathic Molecules Trinitrophenol and Chlorpromazine* , 2007, Journal of Biological Chemistry.

[57]  P. Heppenstall,et al.  Direct activation of the ion channel TRPA1 by Ca2+ , 2007, Nature Neuroscience.

[58]  Jing Xu,et al.  Utility of Large-Scale Transiently Transfected Cells for Cell-Based High-Throughput Screens to Identify Transient Receptor Potential Channel A1 (TRPA1) Antagonists , 2007, Journal of biomolecular screening.

[59]  Peter G. Schultz,et al.  Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines , 2007, Nature.

[60]  A. Patapoutian,et al.  A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition , 2007, Molecular pain.

[61]  N. Gavva,et al.  Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists , 2007, Molecular pain.

[62]  D. Julius,et al.  TRP channel activation by reversible covalent modification , 2006, Proceedings of the National Academy of Sciences.

[63]  Yi Dai,et al.  Antisense knock down of TRPA1, but not TRPM8, alleviates cold hyperalgesia after spinal nerve ligation in rats , 2006, Experimental Neurology.

[64]  Clifford J. Woolf,et al.  TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction , 2006, Neuron.

[65]  David Julius,et al.  TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents , 2006, Cell.

[66]  Yi Dai,et al.  TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. , 2005, The Journal of clinical investigation.

[67]  Olov Sterner,et al.  Pungent products from garlic activate the sensory ion channel TRPA1. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[68]  Barbara Namer,et al.  TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol , 2005, Neuroreport.

[69]  K. Nagata,et al.  Nociceptor and Hair Cell Transducer Properties of TRPA1, a Channel for Pain and Hearing , 2005, The Journal of Neuroscience.

[70]  Heidi L. Rehm,et al.  TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells , 2004, Nature.

[71]  M. Jarvis,et al.  Increased WDR spontaneous activity and receptive field size in rats following a neuropathic or inflammatory injury: implications for mechanical sensitivity , 2004, Neuroscience Letters.

[72]  A. Patapoutian,et al.  Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin , 2004, Neuron.

[73]  D. McKemy,et al.  Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 , 2004, Nature.

[74]  David E. Clapham,et al.  TRP channels as cellular sensors , 2003, Nature.

[75]  Peter McIntyre,et al.  ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures , 2003, Cell.

[76]  C. Montell,et al.  The TRP Channels, a Remarkably Functional Family , 2002, Cell.

[77]  A. Kettle,et al.  Biomarkers of myeloperoxidase-derived hypochlorous acid. , 2000, Free radical biology & medicine.

[78]  R. LaMotte,et al.  Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia. , 1999, Somatosensory & motor research.

[79]  N. Back,et al.  Kinin-like activity in nasal secretions of allergic patients. , 1970, International archives of allergy and applied immunology.