Improved phosphoramidite building blocks for the synthesis of the simplified nucleic acid GNA.
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An improved synthesis of glycol nucleic acids is reported using new phosphoramidite building blocks in which the exocyclic amino groups of adenine and guanine are protected as N-dimethylformamidines, whereas the amino group of cytosine is protected via an acetamide. Besides a more rapid synthesis with higher yields, these phosphoramidites allow the use of a quicker deprotection procedure in the subsequent solid-phase synthesis of GNA oligonucleotides.