Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA
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J. Qi | J. Bradner | X. Wu | H. Zhang | Z. Zou | S. Nair | Xuewei Wu | B. Huang | L-F Chen | Bo Huang | Lin Feng Chen | Zhenhua Zou | Houjin Zhang | Jun Qi | Satish K. Nair
[1] A. Belkina,et al. BET domain co-regulators in obesity, inflammation and cancer , 2012, Nature Reviews Cancer.
[2] Ming-Ming Zhou,et al. Down-regulation of NF-κB Transcriptional Activity in HIV-associated Kidney Disease by BRD4 Inhibition* , 2012, The Journal of Biological Chemistry.
[3] C. French. Pathogenesis of NUT midline carcinoma. , 2012, Annual review of pathology.
[4] Gaoxi Xiao,et al. RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor α , 2012, Oncogene.
[5] N. Perkins,et al. The diverse and complex roles of NF-κB subunits in cancer , 2012, Nature Reviews Cancer.
[6] C. Chung. Small molecule bromodomain inhibitors: extending the druggable genome. , 2012, Progress in medicinal chemistry.
[7] S. Lowe,et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia , 2011, Nature.
[8] Peter A. Jones,et al. A decade of exploring the cancer epigenome — biological and translational implications , 2011, Nature Reviews Cancer.
[9] P. Sandy,et al. Targeting MYC dependence in cancer by inhibiting BET bromodomains , 2011, Proceedings of the National Academy of Sciences.
[10] R. Young,et al. BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc , 2011, Cell.
[11] John M Denu,et al. Disrupting the reader of histone language. , 2011, Angewandte Chemie.
[12] B. Aggarwal,et al. NF-κB addiction and its role in cancer: ‘one size does not fit all’ , 2011, Oncogene.
[13] C. Rice,et al. Suppression of inflammation by a synthetic histone mimic , 2010, Nature.
[14] B. Aggarwal,et al. Inhibiting NF-κB activation by small molecules as a therapeutic strategy. , 2010, Biochimica et biophysica acta.
[15] William B. Smith,et al. Selective inhibition of BET bromodomains , 2010, Nature.
[16] Lin-Feng Chen,et al. Posttranslational modifications of NF-kappaB: another layer of regulation for NF-kappaB signaling pathway. , 2010, Cellular signalling.
[17] S. Smale,et al. Selectivity of the NF-{kappa}B response. , 2010, Cold Spring Harbor perspectives in biology.
[18] E. Tajkhorshid,et al. Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF-κB , 2010, Molecular and Cellular Biology.
[19] C. Chiang,et al. Brd4 engagement from chromatin targeting to transcriptional regulation: selective contact with acetylated histone H3 and H4 , 2009, F1000 biology reports.
[20] Kyung-Chul Choi,et al. Gallic Acid Suppresses Lipopolysaccharide-Induced Nuclear Factor-κB Signaling by Preventing RelA Acetylation in A549 Lung Cancer Cells , 2009, Molecular Cancer Research.
[21] Jennifer A. Smith,et al. Brd4 Regulation of Papillomavirus Protein E2 Stability , 2009, Journal of Virology.
[22] N. Kelleher,et al. Negative regulation of NF‐κB action by Set9‐mediated lysine methylation of the RelA subunit , 2009, The EMBO journal.
[23] Hua Yu,et al. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. , 2009, Cancer cell.
[24] C. Chiang,et al. Chromatin Adaptor Brd4 Modulates E2 Transcription Activity and Protein Stability* , 2009, Journal of Biological Chemistry.
[25] D. Kwon,et al. Papillomavirus E2 Proteins and the Host Brd4 Protein Associate with Transcriptionally Active Cellular Chromatin , 2009, Journal of Virology.
[26] M. Karin,et al. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. , 2009 .
[27] Michael Karin,et al. Is NF-κB a good target for cancer therapy? Hopes and pitfalls , 2009, Nature Reviews Drug Discovery.
[28] Ming-Ming Zhou,et al. Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA , 2008, Molecular and Cellular Biology.
[29] Danny Reinberg,et al. Is there a code embedded in proteins that is based on post-translational modifications? , 2008, Nature Reviews Molecular Cell Biology.
[30] I. Adcock,et al. Epigenetic regulation of airway inflammation. , 2007, Current opinion in immunology.
[31] Shwu‐Yuan Wu,et al. The Double Bromodomain-containing Chromatin Adaptor Brd4 and Transcriptional Regulation* , 2007, Journal of Biological Chemistry.
[32] Lin-Feng Chen,et al. TGF‐β induces p65 acetylation to enhance bacteria‐induced NF‐κB activation , 2007 .
[33] Lin-Feng Chen,et al. TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation. , 2007, The EMBO journal.
[34] N. Perkins. Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway , 2006, Oncogene.
[35] M. Karin. Nuclear factor-κB in cancer development and progression , 2006, Nature.
[36] M. Karin. Nuclear factor-kappaB in cancer development and progression. , 2006, Nature.
[37] A. Baldwin,et al. Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression. , 2006, Oncogene.
[38] Leonard Buckbinder,et al. NF-κB RelA Phosphorylation Regulates RelA Acetylation , 2005, Molecular and Cellular Biology.
[39] P. Dent,et al. Kinase 1 Activation Downregulation, and C-jun N-terminal Mediated by Oxidative Damage, Xiap Leukemia Cells through a Process B Activation Potentiates Apoptosis in Κ Nf- Inhibitor-induced Rela/p65 Acetylation and Blockade of Histone Deacetylase , 2005 .
[40] Michael Karin,et al. NF-kappaB: linking inflammation and immunity to cancer development and progression. , 2005, Nature reviews. Immunology.
[41] Leonard Buckbinder,et al. NF-kappaB RelA phosphorylation regulates RelA acetylation. , 2005, Molecular and cellular biology.
[42] B. Aggarwal,et al. Nuclear factor-kappaB: the enemy within. , 2004, Cancer cell.
[43] S. Saccani,et al. Degradation of Promoter-bound p65/RelA Is Essential for the Prompt Termination of the Nuclear Factor κB Response , 2004, The Journal of experimental medicine.
[44] M. Mayo,et al. Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase , 2004, The EMBO journal.
[45] P. Howley,et al. Interaction of the Bovine Papillomavirus E2 Protein with Brd4 Tethers the Viral DNA to Host Mitotic Chromosomes , 2004, Cell.
[46] W. Greene,et al. Shaping the nuclear action of NF-kappaB. , 2004, Nature reviews. Molecular cell biology.
[47] W. Greene,et al. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF‐κB , 2002, The EMBO journal.
[48] Jerard Hurwitz,et al. A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase , 2002, Molecular and Cellular Biology.
[49] Michael Karin,et al. NF-κB in cancer: from innocent bystander to major culprit , 2002, Nature Reviews Cancer.
[50] M. Karin,et al. Missing Pieces in the NF-κB Puzzle , 2002, Cell.
[51] Michael Karin,et al. NF-kappaB in cancer: from innocent bystander to major culprit. , 2002, Nature reviews. Cancer.
[52] R. Kornberg,et al. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[53] M J May,et al. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. , 1998, Annual review of immunology.
[54] F. Jeanmougin,et al. The bromodomain revisited. , 1997, Trends in biochemical sciences.
[55] E. Zandi,et al. AP-1 function and regulation. , 1997, Current opinion in cell biology.
[56] A. Baldwin,et al. THE NF-κB AND IκB PROTEINS: New Discoveries and Insights , 1996 .
[57] A. Baldwin,et al. The NF-kappa B and I kappa B proteins: new discoveries and insights. , 1996, Annual review of immunology.