Measuring PI3K Activation: Clinicopathologic, Immunohistochemical, and RNA Expression Analysis in Prostate Cancer
暂无分享,去创建一个
M. Loda | P. Kantoff | M. Stampfer | J. Johansson | M. Fiorentino | T. Gerke | N. Martin | E. Stack | L. Mucci | J. Sinnott | S. Andersson | O. Andrén | S. Finn | Giuseppe Fedele
[1] M. Konopleva,et al. Integrative Genomic and Proteomic Analysis Of Low-Dose ionizing Irradiation Effects On Bone Marrow Stromal Microenvironment and On Survival Of Pre-Leukemic Cells , 2013 .
[2] J. Hicks,et al. An immunohistochemical signature comprising PTEN, MYC, and Ki67 predicts progression in prostate cancer patients receiving adjuvant docetaxel after prostatectomy , 2012, Cancer.
[3] A. Sivachenko,et al. Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer , 2012, Nature Genetics.
[4] Katja Fall,et al. Utility of multispectral imaging in automated quantitative scoring of immunohistochemistry , 2012, Journal of Clinical Pathology.
[5] Jordi Rodon,et al. Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[6] Jianfeng Xu,et al. PTEN Protein Loss by Immunostaining: Analytic Validation and Prognostic Indicator for a High Risk Surgical Cohort of Prostate Cancer Patients , 2011, Clinical Cancer Research.
[7] R. Smart,et al. PTEN positively regulates UVB-induced DNA damage repair. , 2011, Cancer research.
[8] T. Golub,et al. mRNA expression signature of Gleason grade predicts lethal prostate cancer. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[9] T. Holzer,et al. Ischemic time impacts biological integrity of phospho-proteins in PI3K/Akt, Erk/MAPK, and p38 MAPK signaling networks. , 2011, Anticancer research.
[10] Sarat Chandarlapaty,et al. Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. , 2011, Cancer cell.
[11] J. Cuzick,et al. Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study. , 2011, The Lancet. Oncology.
[12] J. Lanchbury,et al. A Robust Immunohistochemical Assay for Detecting PTEN Expression in Human Tumors , 2011, Applied immunohistochemistry & molecular morphology : AIMM.
[13] Gerald C. Chu,et al. SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression , 2011, Nature.
[14] Ruedi Aebersold,et al. Cancer genetics-guided discovery of serum biomarker signatures for diagnosis and prognosis of prostate cancer , 2011, Proceedings of the National Academy of Sciences.
[15] M. Dowsett,et al. Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer , 2010, Breast Cancer Research.
[16] Theresa Zhang,et al. Pathway-Based Identification of Biomarkers for Targeted Therapeutics: Personalized Oncology with PI3K Pathway Inhibitors , 2010, Science Translational Medicine.
[17] C. Sander,et al. Integrative genomic profiling of human prostate cancer. , 2010, Cancer cell.
[18] Adrian V. Lee,et al. Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer , 2010, Breast Cancer Research.
[19] Paul Ellis,et al. PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor–positive breast cancer , 2010, Proceedings of the National Academy of Sciences.
[20] M. Belvin,et al. Predictive Biomarkers of Sensitivity to the Phosphatidylinositol 3′ Kinase Inhibitor GDC-0941 in Breast Cancer Preclinical Models , 2010, Clinical Cancer Research.
[21] Adam M. Gustafson,et al. Airway PI3K Pathway Activation Is an Early and Reversible Event in Lung Cancer Development , 2010, Science Translational Medicine.
[22] C. Le Page,et al. Hierarchical clustering of immunohistochemical analysis of the activated ErbB/PI3K/Akt/NF-κB signalling pathway and prognostic significance in prostate cancer , 2010, British Journal of Cancer.
[23] M. Gerstein,et al. Molecular sampling of prostate cancer: a dilemma for predicting disease progression , 2010, BMC Medical Genomics.
[24] M. Loda,et al. Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis , 2009, Science Signaling.
[25] J. Baselga,et al. NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations. , 2008, Cancer research.
[26] C. Belka,et al. Analysis of complex protein kinase B signalling pathways in human prostate cancer samples , 2008, BJU international.
[27] Matthew E Ritchie,et al. Integrative analysis of RUNX1 downstream pathways and target genes , 2008, BMC Genomics.
[28] N. Kinukawa,et al. Increased Akt and phosphorylated Akt expression are associated with malignant biological features of prostate cancer in Japanese men , 2007, BJU international.
[29] D. Troyer,et al. Determining Risk of Biochemical Recurrence in Prostate Cancer by Immunohistochemical Detection of PTEN Expression and Akt Activation , 2007, Clinical Cancer Research.
[30] M. Ringnér,et al. Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity , 2007, Proceedings of the National Academy of Sciences.
[31] S. Horvath,et al. Insulin growth factor-binding protein 2 is a candidate biomarker for PTEN status and PI3K/Akt pathway activation in glioblastoma and prostate cancer , 2007, Proceedings of the National Academy of Sciences.
[32] J. Davis. Bioinformatics and Computational Biology Solutions Using R and Bioconductor , 2007 .
[33] T. Golub,et al. Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators. , 2006, Cancer cell.
[34] Daniel J. Freeman,et al. PTEN Deletion Leads to Up-regulation of a Secreted Growth Factor Pleiotrophin* , 2006, Journal of Biological Chemistry.
[35] John T. Wei,et al. Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. , 2005, Cancer cell.
[36] D. Troyer,et al. Signal transduction pathways in androgen-dependent and -independent prostate cancer cell proliferation. , 2005, Endocrine-related cancer.
[37] T. Pandita,et al. Lack of PTEN sequesters CHK1 and initiates genetic instability. , 2005, Cancer cell.
[38] Gordon K. Smyth,et al. limma: Linear Models for Microarray Data , 2005 .
[39] S. Horvath,et al. Antibody-Based Profiling of the Phosphoinositide 3-Kinase Pathway in Clinical Prostate Cancer , 2004, Clinical Cancer Research.
[40] P. Scardino,et al. High Levels of Phosphorylated Form of Akt-1 in Prostate Cancer and Non-Neoplastic Prostate Tissues Are Strong Predictors of Biochemical Recurrence , 2004, Clinical Cancer Research.
[41] Thomas Wheeler,et al. High Level of Androgen Receptor Is Associated With Aggressive Clinicopathologic Features and Decreased Biochemical Recurrence-free Survival in Prostate: Cancer Patients Treated With Radical Prostatectomy , 2004, The American journal of surgical pathology.
[42] D. Pfaff,et al. Inhibition of neuronal phenotype by PTEN in PC12 cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[43] O. Halvorsen,et al. Combined loss of PTEN and p27 expression is associated with tumor cell proliferation by Ki-67 and increased risk of recurrent disease in localized prostate cancer. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[44] L. Morel,et al. Androgen receptor expression is regulated by the phosphoinositide 3-kinase/Akt pathway in normal and tumoral epithelial cells. , 2002, The Biochemical journal.
[45] D. Troyer,et al. Immunohistochemical demonstration of phospho-Akt in high Gleason grade prostate cancer. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[46] M. Wigler,et al. Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[47] F. Christians,et al. PTEN Expression Causes Feedback Upregulation of Insulin Receptor Substrate 2 , 2001, Molecular and Cellular Biology.
[48] T. Tsunoda,et al. Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN. , 2001, Cancer research.
[49] R. Tibshirani,et al. Significance analysis of microarrays applied to the ionizing radiation response , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[50] J. J. Chen,et al. Profiling the downstream genes of tumor suppressor PTEN in lung cancer cells by complementary DNA microarray. , 2000, American journal of respiratory cell and molecular biology.
[51] M. Loda,et al. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. , 1999, Cancer research.
[52] E. Rimm,et al. Prospective study of alcohol consumption and risk of coronary disease in men , 1991, The Lancet.