Study protocol: stability of morphine injected without preservative, delivered with a disposable infusion device

Background and objective : Morphine hydrochloride, a major analgesic drug, is being increasingly administered using portable disposable infusion devices. The objective of this study was to investigate the stability of morphine in such a system at two concentrations (2·50 and 5·00 mg/ml) over a 30‐day period.Method: High‐performance liquid chromatography of stored morphine solutions.Results: The best stability was observed with disposable infusion devices filled with a morphine solution containing sodium metabisulphite as a preservative. No breakdown products were detected after 1 month of storage at room temperature, in light or darkness.

[1]  J. Grom,et al.  Compounding of preservative-free high-concentration morphine sulfate injection. , 1995, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[2]  H. Liu,et al.  Storage temperature effect on the stability of morphine and codeine in urine. , 1995, Journal of analytical toxicology.

[3]  L. Schaaf,et al.  Shelf‐lives and factors affecting the stability of morphine sulphate and meperidine (pethidine) hydrochloride in plastic syringes for use in patient‐controlled analgesic devices , 1994, Journal of clinical pharmacy and therapeutics.

[4]  H. Wulf,et al.  The stability of mixtures of morphine hydrochloride, bupivacaine hydrochloride, and clonidine hydrochloride in portable pump reservoirs for the management of chronic pain syndromes. , 1994, Journal of Pain and Symptom Management.

[5]  I. Salem,et al.  Determination of the stability of morphine tablets by ion-pair reversed-phase liquid chromatography , 1993 .

[6]  P. Grassby,et al.  Factors affecting the physical and chemical stability of morphine sulphate solutions stored in syringes , 1993 .

[7]  M. Nahata,et al.  Stability of morphine sulfate in bacteriostatic 0.9% sodium chloride injection stored in glass vials at two temperatures. , 1992, American journal of hospital pharmacy.

[8]  M. Doležalová.  Ion-pair high-performance liquid chromatographic determination of morphine and pseudomorphine in injections. , 1992, Journal of pharmaceutical and biomedical analysis.

[9]  S. Ottesen,et al.  [Continuous drug infusion in terminal cancer]. , 1992, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke.

[10]  K. Flora,et al.  Stability of morphine sulfate in infusion devices and containers for intravenous administration. , 1990, American journal of hospital pharmacy.

[11]  L. Allen,et al.  Stability of morphine sulfate in portable pump reservoirs during storage and simulated administration. , 1989, American journal of hospital pharmacy.

[12]  B. Monsarrat,et al.  The stability of morphine in isobaric and hyperbaric solutions in a drug delivery system , 1988, The Journal of pharmacy and pharmacology.

[13]  S Y YEH,et al.  Stability of morphine in aqueous solution. III. Kinetics of morphine degradation in aqueous solution. , 1961, Journal of pharmaceutical sciences.