Secretion of antidiuretic hormone in children with obstructive sleep apnea-hypopnea syndrome

Conclusions: Obstructive sleep apnea-hypopnea syndrome (OSAHS) in children with hypoxemia might influence the nocturnal secretion of antidiuretic hormone (ADH) that is associated with polyuria, even nocturia. Objective: The impact of OSAHS on the secretion levels of ADH was studied in pediatric patients with adenotonsillar hypertrophy. Subjects and methods: Forty-eight children (28 with OSAHS, 20 as normal controls) were recruited in this study. Respiratory indexes of all subjects were monitored by polysomnography and 12-h urinary volume was recorded during sleep. Vein blood was sampled to detect the levels of ADH in serum using a radioimmunoassay technique, both before and after adenotonsillectomy. Results: After surgery for OSAHS, the mean value of the apnea-hypopnea index (AHI) decreased (from 17.36±2.61 to 3.32±1.41, p<0.001), lowest arterial oxygen saturation (LSaO2) increased (from 78.34±13.44 to 95.35±6.24, p<0.001), urine volume (UV) in nocturnal 12 h reduced (from 492±90 to 332±56, p<0.001), and ADH level increased (from 63.08±35.15 to 83.10±21.05, p<0.05). The differences in UV and ADH between postoperative children and healthy controls were not statistically significant (both p>0.05).