An Intensified EMCCD Camera for Low Energy Gamma Ray Imaging Applications

This paper presents the design and feasibility study of a very-high resolution gamma camera for detecting 27-35 keV X and gamma rays emitted by I-125 labelled radiotracers. This detector consists of a newly developed Electron-multiplying CCD (EMCCD) sensor and a de-magnifier tube coupled to a thin layer of scintillator. A prototype detector was developed and experimentally evaluated. This detector has a detection area of ~5times5 cm2. It provided an intrinsic spatial resolution of <60 mum FWHM and a high signal-to-noise ratio for detecting the 27-35 keV photons, which ensures an excellent counting efficiency. This detector will be used as the key component for a single photon emission microscope (SPEM) system that is under development

[1]  N. Clinthorne,et al.  Design and feasibility study of a single photon emission microscope system for small animal I-125 imaging , 2006, IEEE Transactions on Nuclear Science.

[2]  E. Rosso,et al.  X-ray-sensitive hybrid photon detectors with Be-windows , 2005, IEEE Transactions on Nuclear Science.

[3]  P. V. van Rijk,et al.  U-SPECT-I: a novel system for submillimeter-resolution tomography with radiolabeled molecules in mice. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[4]  F. Beekman,et al.  Photon-counting versus an integrating CCD-based gamma camera: important consequences for spatial resolution , 2005, Physics in medicine and biology.

[5]  W. Moses,et al.  Design for a High-Resolution Small-Animal SPECT System Using Pixellated Si(Li) Detectors for In Vivo , 2005 .

[6]  Roberto Pani,et al.  LaBr3:Ce Scintillation Camera , 2005 .

[7]  W. Moses,et al.  Design for a high-resolution small-animal SPECT system using pixellated Si(Li) detectors for in vivo /sup 125/I imaging , 2005, IEEE Transactions on Nuclear Science.

[8]  F. Beekman,et al.  Photon-counting gamma camera based on an electron-multiplying CCD , 2005, IEEE Transactions on Nuclear Science.

[9]  G. Entine,et al.  A CCD-based detector for SPECT , 2004, IEEE Symposium Conference Record Nuclear Science 2004..

[10]  F. Beekman,et al.  Design and simulation of a high-resolution stationary SPECT system for small animals. , 2004, Physics in medicine and biology.

[11]  H. B. Barber,et al.  Compact CT/SPECT small-animal imaging system , 2002, IEEE Transactions on Nuclear Science.

[12]  Freek J. Beekman,et al.  High-resolution emission tomography of small laboratory animals: physics and gamma-astronomy meet molecular biology , 2003 .

[13]  B. Hadwen,et al.  The noise performance of electron multiplying charge-coupled devices , 2003 .

[14]  Donald W. Wilson,et al.  Application of silicon strip detectors to small-animal imaging , 2003 .

[15]  E. Hoffman,et al.  Performance evaluation of A-SPECT: a high resolution desktop pinhole SPECT system for imaging small animals , 2002 .

[16]  Michael W Dae,et al.  Performance evaluation of a pinhole SPECT system for myocardial perfusion imaging of mice. , 2002, Medical physics.

[17]  Harrison H Barrett,et al.  SemiSPECT: a small-animal imaging system based on eight CdZnTe pixel detectors , 2002, 2002 IEEE Nuclear Science Symposium Conference Record.

[18]  Simon R. Cherry,et al.  Towards in vivo nuclear microscopy: iodine-125 imaging in mice using micro-pinholes , 2002, European Journal of Nuclear Medicine and Molecular Imaging.

[19]  R. Wojcik,et al.  SPECT-CT system for small animal imaging , 2001, 2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310).

[20]  P. Dorenbos,et al.  High-energy-resolution scintillator: Ce3+ activated LaBr3 , 2000 .

[21]  H. Kung,et al.  Quantitative autoradiographic studies of dopamine D3 receptors in rat cerebellum using [125I]S(−)5-OH-PIPAT , 1997, Brain Research.

[22]  C. Petersson,et al.  Simulation of the X-ray response of scintillator coated silicon CCDs , 1997, 1997 IEEE Nuclear Science Symposium Conference Record.

[23]  S. Majewski,et al.  Design features and performance of a CsI(Na) array based gamma camera for small animal gene research , 1997, 1997 IEEE Nuclear Science Symposium Conference Record.

[24]  H. Kung,et al.  Binding of 125I‐iodovinyltetrabenazine to CNS vesicular monoamine transport sites , 1994, Synapse.

[25]  P. Molinoff,et al.  Characterization of [125I](R)-trans-7-hydroxy-2-[N-propyl-N-(3'-iodo-2'-propenyl)amino] tetralin binding to dopamine D3 receptors in rat olfactory tubercle. , 1994, The Journal of pharmacology and experimental therapeutics.

[26]  A. Karellas,et al.  Imaging of radionuclide emissions with a low-noise charge-coupled device , 1992, IEEE Conference on Nuclear Science Symposium and Medical Imaging.

[27]  N. Volkow,et al.  A high-resolution SPECT system based on a microchannel-plate imager , 1990 .

[28]  L. Shepp,et al.  Maximum Likelihood PET with Real Data , 1984, IEEE Transactions on Nuclear Science.