Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence.
暂无分享,去创建一个
M. Andrews | A. Brown | P. Fish | P. Brennan | P. Bungay | G. McMurray | J. Blagg | G. Whitlock | M. Holbrook | R. I. Storer | Alan S. Jessiman | M. Sutton | Carly L. Nichols | T. Brabham | D. Westbrook | N. Edmunds | K. Conlon | Colleen P. Gibbons | J. Root | M. P. Green | K. af Forselles | R. Ward | A. Bridgeland | G. Hanton | Karin McIntosh | Martin P. Green | James A Root
[1] N. Weissman,et al. Multicenter, placebo-controlled trial of lorcaserin for weight management. , 2010, The New England journal of medicine.
[2] K. Liu,et al. Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity. , 2010, Bioorganic & medicinal chemistry letters.
[3] Jinping Gan,et al. Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents. , 2010, Bioorganic & medicinal chemistry letters.
[4] Bryan L. Roth,et al. Parallel Functional Activity Profiling Reveals Valvulopathogens Are Potent 5-Hydroxytryptamine2B Receptor Agonists: Implications for Drug Safety Assessment , 2009, Molecular Pharmacology.
[5] M. Andrews,et al. Design and synthesis of pyridazinone-based 5-HT(2C) agonists. , 2009, Bioorganic & medicinal chemistry letters.
[6] David W. Gordon,et al. Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT(2C) agonists. , 2009, Bioorganic & medicinal chemistry letters.
[7] G. McMurray,et al. Pharmacological Properties of 2-((R-5-Chloro-4-methoxymethylindan-1-yl)-1H-imidazole (PF-3774076), a Novel and Selective α1A-Adrenergic Partial Agonist, in in Vitro and in Vivo Models of Urethral Function , 2009, Journal of Pharmacology and Experimental Therapeutics.
[8] P. Brennan,et al. Discovery of a novel azepine series of potent and selective 5-HT2C agonists as potential treatments for urinary incontinence. , 2009, Bioorganic & medicinal chemistry letters.
[9] P. Fish,et al. N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration. , 2009, Bioorganic & medicinal chemistry letters.
[10] Sung Jin Cho,et al. Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action. , 2009, Journal of medicinal chemistry.
[11] A. Brown,et al. 7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: hit-to-lead optimization. , 2009, Bioorganic & medicinal chemistry letters.
[12] J. Bauman,et al. Biochemical basis for differences in metabolism-dependent genotoxicity by two diazinylpiperazine-based 5-HT2C receptor agonists. , 2009, Bioorganic & medicinal chemistry letters.
[13] C. Anderson,et al. Lorcaserin (APD356), a Selective 5‐HT2C Agonist, Reduces Body Weight in Obese Men and Women , 2009, Obesity.
[14] Y. Mbaki,et al. Investigation of the role of 5‐HT2 receptor subtypes in the control of the bladder and the urethra in the anaesthetized female rat , 2008, British journal of pharmacology.
[15] K. Miller,et al. Agonists of the serotonin 5-HT2C receptor: preclinical and clinical progression in multiple diseases. , 2008, Current opinion in drug discovery & development.
[16] Brian M. Smith,et al. Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine2C Agonist: in Vitro and in Vivo Pharmacological Characterization , 2008, Journal of Pharmacology and Experimental Therapeutics.
[17] S. Tsukamoto,et al. Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists. , 2008, Bioorganic & medicinal chemistry.
[18] S. Tsukamoto,et al. Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists. , 2008, Bioorganic & medicinal chemistry.
[19] J. C. Winter,et al. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): Possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents , 2008, Pharmacology Biochemistry and Behavior.
[20] Brian M. Smith,et al. Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity. , 2008, Journal of medicinal chemistry.
[21] K. Marquis,et al. 5-HT2C receptor agonists as an innovative approach for psychiatric disorders. , 2007, Drug news & perspectives.
[22] C. Villalón,et al. Cardiovascular responses produced by 5-hydroxytriptamine:a pharmacological update on the receptors/mechanisms involved and therapeutic implications , 2007, Naunyn-Schmiedeberg's Archives of Pharmacology.
[23] A. Kalgutkar,et al. Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation , 2007, Drug Metabolism And Disposition.
[24] P. Seymour,et al. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity , 2007, Neuropharmacology.
[25] B. Roth. Drugs and valvular heart disease. , 2007, The New England journal of medicine.
[26] S. Hitchcock,et al. Structure-brain exposure relationships. , 2006, Journal of medicinal chemistry.
[27] N. Barnes,et al. Anti-obesity pharmacotherapy: Future perspectives utilising 5-HT2C receptor agonists , 2006 .
[28] E. Lacivita,et al. Selective agents for serotonin2C (5-HT2C) receptor. , 2006, Current topics in medicinal chemistry.
[29] B. Nilsson. 5-Hydroxytryptamine 2C (5-HT2C) receptor agonists as potential antiobesity agents. , 2006, Journal of medicinal chemistry.
[30] Brian M. Smith,et al. The potential use of selective 5-HT2C agonists in treating obesity , 2006, Expert Opinion on Investigational Drugs.
[31] J. Sikorski. Oral cholesteryl ester transfer protein (CETP) inhibitors: a potential new approach for treating coronary artery disease. , 2006, Journal of medicinal chemistry.
[32] M. J. Bishop,et al. New 5-HT2C receptor agonists , 2003 .
[33] D. Harmer,et al. 5‐HT2B receptors play a key role in mediating the excitatory effects of 5‐HT in human colon in vitro , 2002, British journal of pharmacology.
[34] A. Mai,et al. Dihydro(alkylthio)(naphthylmethyl)oxopyrimidines: novel non-nucleoside reverse transcriptase inhibitors of the S-DABO series. , 1997, Journal of medicinal chemistry.
[35] T. Blackburn,et al. Further characterization of 5‐hydroxytryptamine receptors (putative 5‐HT2B) in rat stomach fundus longitudinal muscle , 1994, British Journal of Pharmacology.
[36] J. Barrish. Accounts in drug discovery : case studies in medicinal chemistry , 2011 .
[37] T. Maurer,et al. Design and synthesis of orally-active and selective azaindane 5HT2c agonist for the treatment of obesity. , 2010, Bioorganic & medicinal chemistry letters.
[38] G. Kennett,et al. 5-HT2C ligands: recent progress. , 2008, Progress in medicinal chemistry.
[39] Seiki Yamaguchi,et al. Studies of Seven-membered Heterocyclic Compounds Containing Nitrogen. IX. The Synthesis of 5-Ethoxycarbonyl-1-azacycloheptan-4-one and Its Derivatives , 1968 .