Development of Skin Reaction to Hepatitis B Vaccines in Man

Although there have been many reports concerning immunological responses in type B viral hepatitis, the role of cell-mediated immunity in the pathogenesis of hepatitis B virus (HBV) infection remains uncertain. The presence of cellmediated immunity to hepatitis B surface antigen (HBsAg) has been demonstrated by lymphocyte transformation assay and the migration inhibition test (2-4). Nevertheless, no delayed type hypersensitivity (DTH) skin reaction has been re