Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival
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J. Mottram | P. Volf | V. Geoghegan | J. Carnielli | J. Pitchford | N. Baker | P. Walrad | B. Vojtkova | K. Newling | R. Neish | J. Sádlová | B. Powell | C. M. Catta-Preta | L. Wilson | E. V. Alves-Ferreira | C. Hughes | J. Anand | A. Mihut | Baker N. | Catta-Preta C.M.C. | Neish R. | Sadlova J. | Powell B. | Alves-Ferreira E.V.C. | Geoghegan V. | Carnielli J.B.T. | Newling K. | Hughes C. | Vojtkova B. | Anand J. | Mihut A. | Walrad P.B. | Wilson L.G. | Pitchford J.W. | Volf P. | Mottram J.C. | V. P.
[1] M. Child,et al. The host brain is permissive to colonization by Toxoplasma gondii , 2020 .
[2] M. Child,et al. Cellular barcoding of Toxoplasma reveals permissive host brain colonization , 2020 .
[3] E. Gluenz,et al. Bar-seq strategies for the LeishGEdit toolbox. , 2020, Molecular and biochemical parasitology.
[4] Andreas C. Damianou,et al. Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex , 2020, bioRxiv.
[5] Andreas C. Damianou,et al. Essential roles for deubiquitination in Leishmania life cycle progression , 2020, bioRxiv.
[6] S. Young,et al. Leishmania dual‐specificity tyrosine‐regulated kinase 1 (DYRK1) is required for sustaining Leishmania stationary phase phenotype , 2020, Molecular microbiology.
[7] H. Gingras,et al. Coupling chemical mutagenesis to next generation sequencing for the identification of drug resistance mutations in Leishmania , 2019, Nature Communications.
[8] V. Sebastián-Pérez,et al. Towards discovery of new leishmanicidal scaffolds able to inhibit Leishmania GSK-3 , 2019, Journal of enzyme inhibition and medicinal chemistry.
[9] J. Rayner,et al. Genome-Scale Identification of Essential Metabolic Processes for Targeting the Plasmodium Liver Stage , 2019, Cell.
[10] K. Matthews,et al. An atypical DYRK kinase connects quorum-sensing with posttranscriptional gene regulation in Trypanosoma brucei , 2019, bioRxiv.
[11] R. Wheeler,et al. Cellular landmarks of Trypanosoma brucei and Leishmania mexicana , 2019, Molecular and biochemical parasitology.
[12] Ziyin Li,et al. A kinetochore-based ATM/ATR-independent DNA damage checkpoint maintains genomic integrity in trypanosomes , 2019, Nucleic acids research.
[13] Sarah L. Williams,et al. Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors , 2019, bioRxiv.
[14] Emanuel J. V. Gonçalves,et al. Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens , 2019, Nature.
[15] K. Thormann,et al. Spatial arrangement of several flagellins within bacterial flagella improves motility in different environments , 2018, Nature Communications.
[16] R. Wheeler,et al. Genetic dissection of a Leishmania flagellar proteome demonstrates requirement for directional motility in sand fly infections , 2018, bioRxiv.
[17] Michael D. Urbaniak,et al. Cyclin-dependent kinase 12, a novel drug target for visceral leishmaniasis , 2018, Nature.
[18] S. Kamhawi,et al. Sequential blood meals promote Leishmania replication and reverse metacyclogenesis augmenting vector infectivity , 2018, Nature microbiology.
[19] J. Mottram,et al. Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects , 2018, ACS infectious diseases.
[20] E. Gluenz,et al. Characterisation of Casein Kinase 1.1 in Leishmania donovani Using the CRISPR Cas9 Toolkit , 2017, BioMed research international.
[21] Brent S. Pedersen,et al. Mosdepth: quick coverage calculation for genomes and exomes , 2017, bioRxiv.
[22] J. Mottram,et al. RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse , 2017, Scientific Reports.
[23] K. Gull,et al. Protein diversity in discrete structures at the distal tip of the trypanosome flagellum , 2017, Proceedings of the National Academy of Sciences.
[24] J. Rayner,et al. Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes , 2017, Cell.
[25] E. Gluenz,et al. A CRISPR Cas9 high-throughput genome editing toolkit for kinetoplastids , 2017, Royal Society Open Science.
[26] R. Wheeler,et al. TrypTag.org: A Trypanosome Genome-wide Protein Localisation Resource , 2017, Trends in parasitology.
[27] Partha Palit,et al. Leishmania donovani Aurora kinase: A promising therapeutic target against visceral leishmaniasis. , 2016, Biochimica et biophysica acta.
[28] J. Mottram,et al. Conditional gene deletion with DiCre demonstrates an essential role for CRK3 in L eishmania mexicana cell cycle regulation , 2016, Molecular microbiology.
[29] P. Myler,et al. An Arginine Deprivation Response Pathway Is Induced in Leishmania during Macrophage Invasion , 2016, PLoS pathogens.
[30] J. Lukeš,et al. New Approaches to Systematics of Trypanosomatidae: Criteria for Taxonomic (Re)description. , 2015, Trends in parasitology.
[31] P. Volf,et al. Comparison of Bloodmeal Digestion and the Peritrophic Matrix in Four Sand Fly Species Differing in Susceptibility to Leishmania donovani , 2015, PloS one.
[32] M. Wiese,et al. Transgenic Analysis of the Leishmania MAP Kinase MPK10 Reveals an Auto-inhibitory Mechanism Crucial for Stage-Regulated Activity and Parasite Viability , 2014, PLoS pathogens.
[33] N. Rachidi,et al. Probing druggability and biological function of essential proteins in Leishmania combining facilitated null mutant and plasmid shuffle analyses , 2014, Molecular microbiology.
[34] K. Gull,et al. Discovery of Unconventional Kinetochores in Kinetoplastids , 2014, Cell.
[35] Kristin E. Burnum-Johnson,et al. Metabolic Reprogramming during Purine Stress in the Protozoan Pathogen Leishmania donovani , 2014, PLoS pathogens.
[36] N. Dickens,et al. Regulators of Trypanosoma brucei Cell Cycle Progression and Differentiation Identified Using a Kinome-Wide RNAi Screen , 2014, PLoS pathogens.
[37] L. Meijer,et al. Pharmacological Assessment Defines Leishmania donovani Casein Kinase 1 as a Drug Target and Reveals Important Functions in Parasite Viability and Intracellular Infection , 2013, Antimicrobial Agents and Chemotherapy.
[38] A. Ivens,et al. Genome wide dissection of the quorum sensing signaling pathway in Trypanosoma brucei , 2013, Nature.
[39] C. Jaffe,et al. Identification of a Secreted Casein Kinase 1 in Leishmania donovani: Effect of Protein over Expression on Parasite Growth and Virulence , 2013, PloS one.
[40] A. Schnittger,et al. Cell cycle control across the eukaryotic kingdom. , 2013, Trends in cell biology.
[41] M. Helmer-Citterich,et al. Phosphoproteomic analysis of differentiating Leishmania parasites reveals a unique stage-specific phosphorylation motif. , 2013, Journal of proteome research.
[42] Heng Li. Aligning sequence reads, clone sequences and assembly contigs with BWA-MEM , 2013, 1303.3997.
[43] P. Volf,et al. Leishmania development in sand flies: parasite-vector interactions overview , 2012, Parasites & Vectors.
[44] Markus J. Tamás,et al. Modulation of Leishmania major aquaglyceroporin activity by a mitogen‐activated protein kinase , 2012, Molecular microbiology.
[45] G. H. Coombs,et al. Leishmania mexicana metacaspase is a negative regulator of amastigote proliferation in mammalian cells , 2012, Cell Death and Disease.
[46] A. Tobin,et al. Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum. , 2011, Nature communications.
[47] G. H. Coombs,et al. Morphological Events during the Cell Cycle of Leishmania major , 2011, Eukaryotic Cell.
[48] Marcel Martin. Cutadapt removes adapter sequences from high-throughput sequencing reads , 2011 .
[49] P. Volf,et al. Establishment and Maintenance of Sand Fly Colonies , 2011, Journal of vector ecology : journal of the Society for Vector Ecology.
[50] K. Matthews. Controlling and Coordinating Development in Vector-Transmitted Parasites , 2011, Science.
[51] K. Gull,et al. The cell cycle of Leishmania: morphogenetic events and their implications for parasite biology , 2010, Molecular microbiology.
[52] Alex Bateman,et al. The Systematic Functional Analysis of Plasmodium Protein Kinases Identifies Essential Regulators of Mosquito Transmission , 2010, Cell host & microbe.
[53] D. Depledge,et al. Leishmania-Specific Surface Antigens Show Sub-Genus Sequence Variation and Immune Recognition , 2010, PLoS neglected tropical diseases.
[54] S. Beverley,et al. Expansion of the target of rapamycin (TOR) kinase family and function in Leishmania shows that TOR3 is required for acidocalcisome biogenesis and animal infectivity , 2010, Proceedings of the National Academy of Sciences.
[55] P. Volf,et al. Peritrophic matrix of Phlebotomus duboscqi and its kinetics during Leishmania major development , 2009, Cell and Tissue Research.
[56] B. Porse,et al. Bone Marrow-Derived Macrophages (BMM): Isolation and Applications. , 2008, CSH protocols.
[57] Ching C. Wang,et al. Tousled-like kinase in a microbial eukaryote regulates spindle assembly and S-phase progression by interacting with Aurora kinase and chromatin assembly factors , 2007, Journal of Cell Science.
[58] M. Wiese. Leishmania MAP kinases--familiar proteins in an unusual context. , 2007, International journal for parasitology.
[59] M. Wiese,et al. Interacting protein kinases involved in the regulation of flagellar length. , 2006, Molecular biology of the cell.
[60] M. Wiese,et al. LmxMPK4, a mitogen-activated protein (MAP) kinase homologue essential for promastigotes and amastigotes of Leishmania mexicana , 2005, Kinetoplastid biology and disease.
[61] M. Parsons,et al. Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi , 2005, BMC Genomics.
[62] J. Engel,et al. An essential, putative MEK kinase of Leishmania major. , 2005, Molecular and biochemical parasitology.
[63] P. Myler,et al. Ploidy changes associated with disruption of two adjacent genes on Leishmania major chromosome 1. , 2005, International journal for parasitology.
[64] Daniel Kuhn,et al. LmxPK4, a mitogen‐activated protein kinase kinase homologue of Leishmania mexicana with a potential role in parasite differentiation , 2005, Molecular microbiology.
[65] Daniel Kuhn,et al. LmxMPK9, a mitogen‐activated protein kinase homologue affects flagellar length in Leishmania mexicana , 2005, Molecular microbiology.
[66] Pauline Ward,et al. Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote , 2004, BMC Genomics.
[67] P. Volf,et al. Blocked stomodeal valve of the insect vector: similar mechanism of transmission in two trypanosomatid models. , 2004, International journal for parasitology.
[68] Daniel Kuhn,et al. Protein Kinase Involved in Flagellar-Length Control , 2003, Eukaryotic Cell.
[69] Wojtek J. Krzanowski,et al. Projection Pursuit Clustering for Exploratory Data Analysis , 2003 .
[70] A. Fairlamb,et al. A new expression vector for Crithidia fasciculata and Leishmania. , 2002, Molecular and biochemical parasitology.
[71] S. Beverley,et al. A lipophosphoglycan-independent method for isolation of infective Leishmania metacyclic promastigotes by density gradient centrifugation. , 2001, Experimental parasitology.
[72] J. Mottram,et al. The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana. , 2001, Molecular and biochemical parasitology.
[73] M. Wiese. A mitogen‐activated protein (MAP) kinase homologue of Leishmania mexicana is essential for parasite survival in the infected host , 1998, The EMBO journal.
[74] J. Mottram,et al. Gene disruptions indicate an essential function for the LmmCRK1 cdc2‐related kinase of Leishmania mexicana , 1996, Molecular microbiology.
[75] LAUREL L. Walters,et al. Leishmania Differentiation in Natural and Unnatural Sand Fly Hosts 1 , 1993, The Journal of eukaryotic microbiology.
[76] T. Roberts,et al. The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[77] S. Beverley,et al. Double targeted gene replacement for creating null mutants. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[78] D. Alessi,et al. The nuts and bolts of AGC protein kinases , 2010, Nature Reviews Molecular Cell Biology.