An update on the advancing high-throughput screening techniques for patch clamp-based ion channel screens: implications for drug discovery
暂无分享,去创建一个
Michael George | Søren Friis | Andrea Brüggemann | Claudia Haarmann | Niels Fertig | Nadine Becker | Nina Brinkwirth | Markus Rapedius | Tom A Goetze | Sonja Stölzle-Feix | Alison Obergrussberger | N. Fertig | M. George | A. Obergrussberger | C. Haarmann | Nadine Becker | Nina Brinkwirth | S. Friis | T. Goetze | Markus Rapedius | A. Brüggemann | Ilka Rinke-Weiß | Sonja Stölzle-Feix | Ilka Rinke-Weiß
[1] Icilio Cavero,et al. Comprehensive in vitro Proarrhythmia Assay, a novel in vitro/in silico paradigm to detect ventricular proarrhythmic liability: a visionary 21st century initiative , 2014, Expert opinion on drug safety.
[2] Tianbo Li,et al. High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE , 2017, PloS one.
[3] Andrea Brüggemann,et al. pH-sensitive K(+) channel TREK-1 is a novel target in pancreatic cancer. , 2016, Biochimica et biophysica acta.
[4] Y. Shimansky,et al. Contributions of Different Modes of TRPV1 Activation to TRPV1 Antagonist-Induced Hyperthermia , 2010, The Journal of Neuroscience.
[5] Gary R. Mirams,et al. Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG. , 2012, Journal of molecular and cellular cardiology.
[6] Carlos G. Vanoye,et al. Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy , 2017, Neurology: Genetics.
[7] C. Grimm,et al. The Chimeric Approach Reveals That Differences in the TRPV1 Pore Domain Determine Species-specific Sensitivity to Block of Heat Activation* , 2011, The Journal of Biological Chemistry.
[8] N. Fertig,et al. Automated Patch Clamp Analysis of nAChα7 and NaV1.7 Channels , 2014, Current protocols in pharmacology.
[9] Clemens Möller,et al. Automated planar patch-clamp. , 2013, Methods in molecular biology.
[10] Ralf Kettenhofen,et al. State-of-the-Art Automated Patch Clamp Devices: Heat Activation, Action Potentials, and High Throughput in Ion Channel Screening , 2011, Front. Pharmacol..
[11] Sonja Stoelzle,et al. Microchip technology for automated and parallel patch-clamp recording. , 2006, Small.
[12] N. Fertig,et al. Investigation of the Ion Channels TMEM16A and TRPC5 and their Modulation by Intracellular Calcium , 2017 .
[13] D. Schild,et al. Low frequency voltage clamp: recording of voltage transients at constant average command voltage , 2000, Journal of Neuroscience Methods.
[14] G. Gintant,et al. Evolution of strategies to improve preclinical cardiac safety testing , 2016, Nature Reviews Drug Discovery.
[15] Andrea Brüggemann,et al. Novel screening techniques for ion channel targeting drugs , 2015, Channels.
[16] C. January,et al. Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature. , 1998, Biophysical journal.
[17] Michael George,et al. Automated Patch Clamp Meets High-Throughput Screening , 2016, Journal of laboratory automation.
[18] Rahul R Kauthale,et al. Assessment of temperature‐induced hERG channel blockade variation by drugs , 2017, Journal of applied toxicology : JAT.
[19] A. George,et al. Use-Dependent Block of Human Cardiac Sodium Channels by GS967 , 2016, Molecular Pharmacology.
[20] Ronald Wilders,et al. Dynamic clamp: a powerful tool in cardiac electrophysiology , 2006, The Journal of physiology.
[21] Damian C Bell,et al. Using automated patch clamp electrophysiology platforms in pain‐related ion channel research: insights from industry and academia , 2018, British journal of pharmacology.
[22] C. January,et al. IK1-enhanced human-induced pluripotent stem cell-derived cardiomyocytes: an improved cardiomyocyte model to investigate inherited arrhythmia syndromes. , 2016, American journal of physiology. Heart and circulatory physiology.
[23] Michael George,et al. Characterizing Human Ion Channels in Induced Pluripotent Stem Cell–Derived Neurons , 2012, Journal of biomolecular screening.
[24] Jon T. Brown,et al. Voltage- and Temperature-Dependent Allosteric Modulation of α7 Nicotinic Receptors by PNU120596 , 2011, Front. Pharmacol..
[25] Qinlian Zhou,et al. Electronic "expression" of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells. , 2013, Heart rhythm.
[26] Yuji Haraguchi,et al. Electrophysiological analysis of mammalian cells expressing hERG using automated 384-well-patch-clamp , 2015, BMC Pharmacology and Toxicology.
[27] Chris Chambers,et al. High-Throughput Screening of Na(V)1.7 Modulators Using a Giga-Seal Automated Patch Clamp Instrument. , 2016, Assay and drug development technologies.
[28] Michael George,et al. Automated ion channel screening: patch clamping made easy , 2007, Expert opinion on therapeutic targets.
[29] Michael Xavier Doss,et al. Maximum Diastolic Potential of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Depends Critically on IKr , 2012, PloS one.
[30] Cristian Ionescu-Zanetti,et al. IonFlux: a microfluidic patch clamp system evaluated with human Ether-à-go-go related gene channel physiology and pharmacology. , 2011, Assay and drug development technologies.
[31] Gary Gintant,et al. Rechanneling the cardiac proarrhythmia safety paradigm: a meeting report from the Cardiac Safety Research Consortium. , 2014, American heart journal.
[32] Feng Zhang,et al. Channelrhodopsin-2 and optical control of excitable cells , 2006, Nature Methods.
[33] Dirk Trauner,et al. Restoring Visual Function to Blind Mice with a Photoswitch that Exploits Electrophysiological Remodeling of Retinal Ganglion Cells , 2014, Neuron.
[34] Martin Biel,et al. Photopharmacological control of bipolar cells restores visual function in blind mice , 2017, The Journal of clinical investigation.
[35] J. Nerbonne,et al. Molecular physiology of cardiac repolarization. , 2005, Physiological reviews.
[36] C. January,et al. Mechanism of block and identification of the verapamil binding domain to HERG potassium channels. , 1999, Circulation research.
[37] D. Trauner,et al. Photoswitchable fatty acids enable optical control of TRPV1 , 2015, Nature Communications.
[38] Dirk Trauner,et al. Photochemical Restoration of Visual Responses in Blind Mice , 2012, Neuron.
[39] Mark L Dallas,et al. Robotic multiwell planar patch-clamp for native and primary mammalian cells , 2009, Nature Protocols.
[40] A. V. van Ginneken,et al. Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual IK1 , 2015, Front. Physiol..
[41] R. Peri,et al. High-throughput electrophysiology: an emerging paradigm for ion-channel screening and physiology , 2008, Nature Reviews Drug Discovery.
[42] Yi Liu,et al. QPatch: the missing link between HTS and ion channel drug discovery. , 2009, Combinatorial chemistry & high throughput screening.
[43] S. Friis,et al. Characterization of compounds on nicotinic acetylcholine receptor alpha7 channels using higher throughput electrophysiology , 2009, Journal of Neuroscience Methods.
[44] Michael George,et al. Port-a-patch and patchliner: high fidelity electrophysiology for secondary screening and safety pharmacology. , 2009, Combinatorial chemistry & high throughput screening.
[45] Xuebin B. Yang,et al. Automated Electrophysiological and Pharmacological Evaluation of Human Pluripotent Stem Cell-Derived Cardiomyocytes , 2016, Stem cells and development.
[46] Nadine Becker,et al. A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time , 2018, Front. Physiol..