Microscopic observation and mechanism discussion for the changes of mouse skin after interacted by intense pulse light

The technologies based on Differential Interference Contrast microscopy (DIC), Laser Scanning Confocal Microscopy (LSCM), Two Photon Emission Laser Scanning Microscopy (TPELSM) and Optical Coherent Tomography (OCT) were used to study the changes of mouse skin after irradiated by Intense Pulse Light (IPL). The experimental results were compared and analyzed by different microscopic observation tools. The relations of the epithelial or dermal interaction with IPL in different energy density were given, and the morphologic changes of mouse skin were observed before and after days irradiated respectively. The function of dermal collagen during the renovating of the tissue and the key factors were presented.

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