Protein tolerance to random amino acid change.
暂无分享,去创建一个
Juno Choe | L. Loeb | H. Guo | Juno Choe | Lawrence A Loeb | Haiwei H Guo
[1] L. Samson,et al. Imbalanced Base Excision Repair Increases Spontaneous Mutation and Alkylation Sensitivity inEscherichia coli , 1999, Journal of bacteriology.
[2] L. Loeb,et al. Random Sequence Mutagenesis and Resistance to 5-Fluorouridine in Human Thymidylate Synthases* , 1998, The Journal of Biological Chemistry.
[3] M. Black,et al. Identification of important residues within the putative nucleoside binding site of HSV-1 thymidine kinase by random sequence selection: analysis of selected mutants in vitro. , 1993, Biochemistry.
[4] Michael H. Hecht,et al. Protein Design: The Choice of de Novo Sequences* , 1997, The Journal of Biological Chemistry.
[5] K. Loeb,et al. Multiple mutations and cancer , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[6] J. Mullins,et al. Lethal mutagenesis of HIV with mutagenic nucleoside analogs. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[7] J. Drake,et al. Rates of spontaneous mutation. , 1998, Genetics.
[8] Peter D. Keightley,et al. High genomic deleterious mutation rates in hominids , 1999, Nature.
[9] John Maynard Smith,et al. Natural Selection and the Concept of a Protein Space , 1970, Nature.
[10] C Cruz,et al. Genetic studies of the lac repressor. XIV. Analysis of 4000 altered Escherichia coli lac repressors reveals essential and non-essential residues, as well as "spacers" which do not require a specific sequence. , 1994, Journal of molecular biology.
[11] M. Zaccolo,et al. The effect of high-frequency random mutagenesis on in vitro protein evolution: a study on TEM-1 beta-lactamase. , 1999, Journal of molecular biology.
[12] S. Henikoff,et al. Predicting deleterious amino acid substitutions. , 2001, Genome research.
[13] L. Loeb,et al. Distribution of Mutations in Human Thymidylate Synthase Yielding Resistance to 5-Fluorodeoxyuridine* , 2002, Journal of Biological Chemistry.
[14] L. Hood,et al. Random mutagenesis of Thermus aquaticus DNA polymerase I: concordance of immutable sites in vivo with the crystal structure. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[15] S. Bouvier,et al. Systematic mutation of bacteriophage T4 lysozyme. , 1991, Journal of molecular biology.
[16] A. Fersht,et al. A search for single substitutions that eliminate enzymatic function in a bacterial ribonuclease. , 1998, Biochemistry.
[17] Christopher T. Saunders,et al. Evaluation of structural and evolutionary contributions to deleterious mutation prediction. , 2002, Journal of molecular biology.
[18] L. Loeb,et al. Mutations in human DNA polymerase η motif II alter bypass of DNA lesions , 2001, The EMBO journal.
[19] M D Wyatt,et al. Molecular basis for discriminating between normal and damaged bases by the human alkyladenine glycosylase, AAG. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[20] F. Taddei,et al. Evolution of Evolvability a , 1999 .
[21] L. Samson,et al. Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA Mechanisms for Nucleotide Flipping and Base Excision , 1998, Cell.
[22] P H Patel,et al. DNA polymerase active site is highly mutable: evolutionary consequences. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[23] L. Loeb,et al. Human Immunodeficiency Virus Reverse Transcriptase , 1996, The Journal of Biological Chemistry.
[24] R. Sauer,et al. Additivity of mutant effects assessed by binomial mutagenesis. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[25] W. Lim,et al. Deciphering the message in protein sequences: tolerance to amino acid substitutions. , 1990, Science.
[26] T. O'Connor,et al. Purification and characterization of human 3-methyladenine-DNA glycosylase. , 1993, Nucleic acids research.
[27] James Allan,et al. 3‐methyladenine DNA glycosylases: structure, function, and biological importance , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.
[28] L. Samson,et al. Cloning and characterization of a 3-methyladenine DNA glycosylase cDNA from human cells whose gene maps to chromosome 16. , 1991, Proceedings of the National Academy of Sciences of the United States of America.
[29] M. Malim,et al. DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses , 2003, Nature Immunology.