Activation during the Trail Making Test measured with functional near-infrared spectroscopy in healthy elderly subjects

Cognitive decline is very common in age and particularly in subjects with neurodegenerative conditions. Besides memory and language, executive functions are very often affected in elderly and patients with Alzheimer's disease or Parkinson's disease. However, the neural alterations associated with these executive deficits are still not fully understood. Therefore, we measured cortical activation using functional near-infrared spectroscopy (fNIRS) in 16 healthy elderly subjects (50-75 years) performing the Trail Making Test (TMT), a widely used neuropsychological instrument measuring executive function. In line with previous studies focusing on younger subjects, the results showed frontal activation during the TMT A and the TMT B in the dorsolateral prefrontal cortex, the frontopolar area and also Broca's area. Furthermore, significant activation in the left motor, somatosensory cortices and somatosensory association cortices was demonstrated. Additionally, after a median split the differences between younger (<58 years) and older (>58 years) subjects were analyzed with the older subjects showing a less focused prefrontal activation. Altogether, fNIRS was found to be suitable to detect cortical activation in elderly subjects during performance of the TMT as well as aging-related differences in prefrontal activation topography. These neural correlates of executive functions should be further investigated as a potential prodromal neural marker of executive deficits and neurodegenerative processes.

[1]  A. Fallgatter,et al.  Nah-Infrarot-Spektroskopie in der Psychiatrie , 2004, Der Nervenarzt.

[2]  Marco Ferrari,et al.  A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application , 2012, NeuroImage.

[3]  Deborah Blacker,et al.  Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment. , 2007, Archives of general psychiatry.

[4]  P. Weber,et al.  Cerebral Hemodynamic Changes in Response to an Executive Function Task in Children with Attention-Deficit Hyperactivity Disorder Measured by Near-Infrared Spectroscopy , 2005, Journal of developmental and behavioral pediatrics : JDBP.

[5]  P. Remy,et al.  Executive function deficits in early Alzheimer's disease and their relations with episodic memory. , 2006, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[6]  D. Stuss,et al.  Adult clinical neuropsychology: lessons from studies of the frontal lobes. , 2002, Annual review of psychology.

[7]  H. Wittchen,et al.  SKID. Strukturiertes Klinisches Interview für DSM-IV. Achse I und II. Handanweisung , 1997 .

[8]  G. Ratcliff,et al.  Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented , 2000, Neurology.

[9]  Ann-Christine Ehlis,et al.  Event-related functional near-infrared spectroscopy (fNIRS): Are the measurements reliable? , 2006, NeuroImage.

[10]  Masao Iwase,et al.  Frontal cortex activation associated with speeded processing of visuospatial working memory revealed by multichannel near-infrared spectroscopy during Advanced Trail Making Test performance , 2010, Behavioural Brain Research.

[11]  H. Yamashita,et al.  Depressive symptoms and apathy are associated with psychomotor slowness and frontal activation , 2012, European Archives of Psychiatry and Clinical Neuroscience.

[12]  S. Crowe,et al.  The differential contribution of mental tracking, cognitive flexibility, visual search, and motor speed to performance on parts A and B of the Trail Making Test. , 1998, Journal of clinical psychology.

[13]  M. Culic,et al.  Gender differences in brain areas involved in silent counting by means of fMRI , 2010, Nonlinear biomedical physics.

[14]  A. Ehlis,et al.  Simulation of Near-Infrared Light Absorption Considering Individual Head and Prefrontal Cortex Anatomy: Implications for Optical Neuroimaging , 2011, PloS one.

[15]  H. Garavan,et al.  An fMRI investigation of a novel analogue to the Trail-Making Test , 2011, Brain and Cognition.

[16]  H. Wittchen,et al.  Strukturiertes Klinisches Interview (und Fragebogen) für DSM-IV (SKID-II), Achse II (Persönlichkeitsstörungen). Eine deutschsprachige, erweiterte Bearbeitung der amerikanischen Originalversion des SCID-II von: M.B. First, R.L. Spitzer, M. Gibbon, J.B.W. Williams, L. Benjamin (Version 3/96) , 1996 .

[17]  M. Herrmann,et al.  [Near-infrared spectroscopy in psychiatry]. , 2004, Der Nervenarzt.

[18]  Dean C Delis,et al.  Specific Measures of Executive Function Predict Cognitive Decline in Older Adults , 2011, Journal of the International Neuropsychological Society.

[19]  T. Owens,et al.  A Functional Neuroimaging Analysis of the Trail Making Test-B: Implications for Clinical Application , 2011, Behavioural neurology.

[20]  M. Notoya,et al.  Identification of three factors influencing trail making test performance using multichannel near-infrared spectroscopy. , 2011, The Tohoku journal of experimental medicine.

[21]  R. Mohs,et al.  Consortium to establish a registry for Alzheimer's disease (CERAD) clinical and neuropsychological assessment of Alzheimer's disease. , 2002, Psychopharmacology bulletin.

[22]  A. Ehlis,et al.  Functional near Infrared Spectroscopy in Psychiatry: A Critical Review , 2012 .

[23]  P. Weber,et al.  Attention-induced frontal brain activation measured by near-infrared spectroscopy. , 2004, Pediatric neurology.

[24]  H. Jasper.  Report of the committee on methods of clinical examination in electroencephalography , 1958 .

[25]  T. Tombaugh.  Trail Making Test A and B: normative data stratified by age and education. , 2004, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[26]  Ivanei E. Bramati,et al.  The cerebral correlates of set-shifting: an fMRI study of the trail making test. , 2002, Arquivos de neuro-psiquiatria.

[27]  Peter Weber,et al.  Methylphenidate-Induced Changes in Cerebral Hemodynamics Measured by Functional Near-Infrared Spectroscopy , 2007, Journal of child neurology.

[28]  S. Holm.  A Simple Sequentially Rejective Multiple Test Procedure , 1979 .

[29]  S. Graham,et al.  An fMRI study of the Trail Making Test , 2005, Neuropsychologia.

[30]  Lars Bäckman,et al.  Cognitive impairment in preclinical Alzheimer's disease: a meta-analysis. , 2005, Neuropsychology.

[31]  T. Ohmori,et al.  Activation of the prefrontal cortex during the Trail‐Making Test detected with multichannel near‐infrared spectroscopy , 2007, Psychiatry and clinical neurosciences.

[32]  J. Corrigan,et al.  Relationships between parts A and B of the Trail Making Test. , 1987, Journal of clinical psychology.

[33]  Daniel N. Allen,et al.  Trail-Making Test , 2010 .

[34]  D. Salmon,et al.  Therapy for Specific Problems Therapy for Specific Problems : Youth Tobacco Cessation , 2009 .

[35]  D. Delis,et al.  Neuropsychological Contributions to the Early Identification of Alzheimer’s Disease , 2008, Neuropsychology Review.

[36]  M. Albert,et al.  Preclinical prediction of AD using neuropsychological tests , 2001, Journal of the International Neuropsychological Society.

[37]  T. Braver,et al.  The Role of Frontopolar Cortex in Subgoal Processing during Working Memory , 2002, NeuroImage.

[38]  Jacob Cohen.  Statistical Power Analysis for the Behavioral Sciences , 1969, The SAGE Encyclopedia of Research Design.

[39]  T. Kitawaki,et al.  Increase in Prefrontal Cortex Blood Flow during the Computer Version Trail Making Test , 2009, Neuropsychobiology.