MALDI Imaging Mass Spectrometry-A Mini Review of Methods and Recent Developments.

As the only imaging method available, Imaging Mass Spectrometry (IMS) can determine both the identity and the distribution of hundreds of molecules on tissue sections, all in one single run. IMS is becoming an established research technology, and due to recent technical and methodological improvements the interest in this technology is increasing steadily and within a wide range of scientific fields. Of the different IMS methods available, matrix-assisted laser desorption/ionization (MALDI) IMS is the most commonly employed. The course at IMSC 2012 in Kyoto covered the fundamental principles and techniques of MALDI-IMS, assuming no previous experience in IMS. This mini review summarizes the content of the one-day course and describes some of the most recent work performed within this research field.

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[12]  Mitsutoshi Setou,et al.  Visualization of acetylcholine distribution in central nervous system tissue sections by tandem imaging mass spectrometry , 2012, Analytical and Bioanalytical Chemistry.

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[15]  Christoph H Borchers,et al.  Dithranol as a MALDI matrix for tissue imaging of lipids by Fourier transform ion cyclotron resonance mass spectrometry. , 2012, Analytical chemistry.

[16]  Pierre P Massion,et al.  High‐throughput proteomic analysis of formalin‐fixed paraffin‐embedded tissue microarrays using MALDI imaging mass spectrometry , 2008, Proteomics.

[17]  Mats Borén,et al.  Stopping the clock on proteomic degradation by heat treatment at the point of tissue excision , 2010, Proteomics.

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[19]  Kazuki Maeda,et al.  Alkylated dihydroxybenzoic acid as a MALDI matrix additive for hydrophobic peptide analysis. , 2012, Analytical chemistry.

[20]  Kristine Glunde,et al.  An Alternative Paper Based Tissue Washing Method for Mass Spectrometry Imaging: Localized Washing and Fragile Tissue Analysis , 2011, Journal of the American Society for Mass Spectrometry.

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[22]  Edward S Yeung,et al.  Use of mass spectrometry for imaging metabolites in plants. , 2012, The Plant journal : for cell and molecular biology.

[23]  Yinlong Guo,et al.  Chemical and biochemical applications of MALDI TOF-MS based on analyzing the small organic compounds. , 2013, Topics in current chemistry.

[24]  Hiroyuki Inoue,et al.  Distribution measurements of 3,4-methylenedioxymethamphetamine and its metabolites in organs by matrix-assisted laser desorption/ionization imaging mass spectrometry using an automatic matrix spraying system with an air brush and a turntable , 2012, Analytical and Bioanalytical Chemistry.

[25]  M. Stoeckli,et al.  Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole-body tissue sections , 2007 .

[26]  Maria C Prieto Conaway,et al.  Evaluation of an accurate mass approach for the simultaneous detection of drug and metabolite distributions via whole-body mass spectrometric imaging. , 2012, Analytical chemistry.

[27]  Brendan Prideaux,et al.  Mass spectrometry imaging for drug distribution studies. , 2012, Journal of proteomics.

[28]  Per E Andrén,et al.  Novel mass spectrometry imaging software assisting labeled normalization and quantitation of drugs and neuropeptides directly in tissue sections. , 2012, Journal of proteomics.

[29]  Sören-Oliver Deininger,et al.  MALDI imaging combined with hierarchical clustering as a new tool for the interpretation of complex human cancers. , 2008, Journal of proteome research.

[30]  Richard M. Caprioli,et al.  Solvent-free matrix dry-coating for MALDI imaging of phospholipids , 2008, Journal of the American Society for Mass Spectrometry.

[31]  Michel Salzet,et al.  Ionic matrices pre-spotted matrix-assisted laser desorption/ionization plates for patient maker following in course of treatment, drug titration, and MALDI mass spectrometry imaging. , 2013, Analytical biochemistry.

[32]  François Bouzom,et al.  Quantitative mass spectrometry imaging of propranolol and olanzapine using tissue extinction calculation as normalization factor. , 2012, Journal of proteomics.

[33]  Morgan C. Giddings,et al.  Baking a mass-spectrometry data PIE with McMC and simulated annealing: predicting protein post-translational modifications from integrated top-down and bottom-up data , 2011, Bioinform..

[34]  Edward S Yeung,et al.  High-spatial and high-mass resolution imaging of surface metabolites of Arabidopsis thaliana by laser desorption-ionization mass spectrometry using colloidal silver. , 2010, Analytical chemistry.

[35]  A. Pitt,et al.  A solvent-free matrix application method for matrix-assisted laser desorption/ionization imaging of small molecules. , 2010, Rapid communications in mass spectrometry : RCM.

[36]  P. Chaurand,et al.  Enhancement of protein sensitivity for MALDI imaging mass spectrometry after chemical treatment of tissue sections , 2008, Journal of the American Society for Mass Spectrometry.

[37]  R. Heeren,et al.  Mass spectrometry images acylcarnitines, phosphatidylcholines, and sphingomyelin in MDA-MB-231 breast tumor models[S] , 2013, Journal of Lipid Research.

[38]  Richard J A Goodwin,et al.  Sample preparation for mass spectrometry imaging: small mistakes can lead to big consequences. , 2012, Journal of proteomics.

[39]  M. Setou,et al.  In situ proteomics with imaging mass spectrometry and principal component analysis in the Scrapper‐knockout mouse brain , 2008, Proteomics.

[40]  Michel Salzet,et al.  2 Ionic matrices pre-spotted matrix-assisted laser desorption/ionization plates for 3 patient marker following, drug titration, and MALDI mass spectrometry imaging , 2012 .

[41]  Richard J A Goodwin,et al.  The significance of ambient-temperature on pharmaceutical and endogenous compound abundance and distribution in tissues sections when analyzed by matrix-assisted laser desorption/ionization mass spectrometry imaging. , 2012, Rapid communications in mass spectrometry : RCM.