Structural basis of selective cannabinoid CB2 receptor activation
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L. Heitman | A. Lichtman | M. van der Stelt | Lijie Wu | P. Pacher | T. Hua | P. Mukhopadhyay | R. J. van den Berg | J. Pálóczi | Mohammed A. Mustafa | Xiaoting Li | Cas van der Horst | A. Janssen | Hao Chang | Jara Bouma | Laura V. de Paus | Sanjay Sunil Kumar | Yanan Yu | Zhi-Jie Liu | Mario van der Stelt | J. Paloczi | L. V. de Paus | Zhijie Liu
[1] E. El-demerdash,et al. The Cannabinoid-2 receptor agonist, 1-phenylisatin, protects against cisplatin-induced nephrotoxicity in mice. , 2022, Life sciences.
[2] N. Grimsey,et al. Developing the Cannabinoid Receptor 2 (CB2) pharmacopoeia: past, present, and future. , 2022, Trends in pharmacological sciences.
[3] Lin Cheng,et al. Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1 , 2022, Nature Chemical Biology.
[4] F. Park,et al. Cannabinoid Type 2 Receptor Activation Reduces the Progression of Kidney Fibrosis Using a Mouse Model of Unilateral Ureteral Obstruction. , 2022, Cannabis and cannabinoid research.
[5] Qing-Rong Liu,et al. Anti-Inflammatory and Pro-Autophagy Effects of the Cannabinoid Receptor CB2R: Possibility of Modulation in Type 1 Diabetes , 2022, Frontiers in Pharmacology.
[6] R. Riera,et al. Efficacy and safety of therapeutic use of cannabis derivatives and their synthetic analogs: Overview of systematic reviews , 2021, Phytotherapy research : PTR.
[7] G. V. van Westen,et al. Identification of V6.51L as a selectivity hotspot in stereoselective A2B adenosine receptor antagonist recognition , 2021, Scientific Reports.
[8] U. Grether,et al. Cannabinoid receptor type 2 ligands: an analysis of granted patents since 2010. , 2021, Pharmaceutical patent analyst.
[9] S. Hanauer,et al. Safety, Pharmacokinetics, and Efficacy of Olorinab, a Peripherally Acting, Highly Selective, Full Agonist of the Cannabinoid Receptor 2, in a Phase 2a Study of Patients With Chronic Abdominal Pain Associated With Crohn’s Disease , 2020, Crohn's & colitis 360.
[10] S. Vlachou,et al. A Critical Review of the Role of the Cannabinoid Compounds Δ9-Tetrahydrocannabinol (Δ9-THC) and Cannabidiol (CBD) and their Combination in Multiple Sclerosis Treatment , 2020, Molecules.
[11] M. Stockler,et al. Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting (CINV): a randomised, placebo-controlled, phase 2 crossover trial. , 2020, Annals of oncology : official journal of the European Society for Medical Oncology.
[12] Whitney Mortensen,et al. Clinical Data for the Use of Cannabis-Based Treatments: A Comprehensive Review of the Literature , 2020, The Annals of pharmacotherapy.
[13] N. Kaminski,et al. Targeting Cannabinoid Receptor 2 on Peripheral Leukocytes to Attenuate Inflammatory Mechanisms Implicated in HIV-Associated Neurocognitive Disorder , 2020, Journal of Neuroimmune Pharmacology.
[14] L. Heitman,et al. Perspective: Implications of Ligand-Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors. , 2020, ACS pharmacology & translational science.
[15] Yong Chen,et al. Structural basis of ligand recognition and self-activation of orphan GPR52 , 2020, Nature.
[16] Suwen Zhao,et al. Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures , 2020, Cell.
[17] Junmei Wang,et al. Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex , 2020, Cell.
[18] K. Erdélyi,et al. Cannabinoid-2 receptor activation ameliorates hepatorenal syndrome. , 2019, Free radical biology & medicine.
[19] S. Natesan,et al. Does the Lipid Bilayer Orchestrate Access and Binding of Ligands to Transmembrane Orthosteric/Allosteric Sites of G Protein-Coupled Receptors? , 2019, Molecular Pharmacology.
[20] D. Rosenbaum,et al. Structure of an allosteric modulator bound to the CB1 cannabinoid receptor , 2019, Nature Chemical Biology.
[21] D. Greaves,et al. The Impact of Cannabinoid Receptor 2 Deficiency on Neutrophil Recruitment and Inflammation. , 2019, DNA and cell biology.
[22] M. Çakır,et al. The protective effect of cannabinoid type 2 receptor activation on renal ischemia–reperfusion injury , 2019, Molecular and Cellular Biochemistry.
[23] J. Giraldo,et al. Revealing the Mechanism of Agonist-Mediated Cannabinoid Receptor 1 (CB1) Activation and Phospholipid-Mediated Allosteric Modulation. , 2019, Journal of medicinal chemistry.
[24] M. R. Iyer,et al. Crystal Structure of the Human Cannabinoid Receptor CB2 , 2019, Cell.
[25] Ron O. Dror,et al. Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex , 2019, Cell.
[26] C. Lucas,et al. The pharmacokinetics and the pharmacodynamics of cannabinoids. , 2018, British journal of clinical pharmacology.
[27] J. Heymann,et al. Single particle reconstruction and validation using Bsoft for the map challenge. , 2018, Journal of structural biology.
[28] Mark W. H. Hoorens,et al. Structure‐kinetic relationship studies of cannabinoid CB2 receptor agonists reveal substituent‐specific lipophilic effects on residence time , 2018, Biochemical pharmacology.
[29] M. Badowski,et al. Dronabinol oral solution in the management of anorexia and weight loss in AIDS and cancer , 2018, Therapeutics and clinical risk management.
[30] S. Steffens,et al. Cardiovascular effects of marijuana and synthetic cannabinoids: the good, the bad, and the ugly , 2018, Nature Reviews Cardiology.
[31] R. J. Doerksen,et al. Selective Cannabinoid 2 Receptor Stimulation Reduces Tubular Epithelial Cell Damage after Renal Ischemia-Reperfusion Injury , 2018, The Journal of Pharmacology and Experimental Therapeutics.
[32] Albert C. Pan,et al. Entry from the Lipid Bilayer: A Possible Pathway for Inhibition of a Peptide G Protein-Coupled Receptor by a Lipophilic Small Molecule. , 2015, Biochemistry.
[33] I. Gaidarov,et al. Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain. , 2017, ACS medicinal chemistry letters.
[34] A. IJzerman,et al. A Novel Selective Inverse Agonist of the CB2 Receptor as a Radiolabeled Tool Compound for Kinetic Binding Studies , 2017, Molecular Pharmacology.
[35] Shan Jiang,et al. Crystal structures of agonist-bound human cannabinoid receptor CB1 , 2017, Nature.
[36] David J. Fleet,et al. cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination , 2017, Nature Methods.
[37] H. de Vries,et al. Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity , 2017, Nature Communications.
[38] A. Howlett,et al. CB1 and CB2 Receptor Pharmacology. , 2017, Advances in pharmacology.
[39] Slawomir Filipek,et al. Hydrophobic Ligand Entry and Exit Pathways of the CB1 Cannabinoid Receptor , 2016, J. Chem. Inf. Model..
[40] Jie Yin,et al. High-resolution crystal structure of the human CB1 cannabinoid receptor , 2016, Nature.
[41] R. Stevens,et al. Crystal Structure of the Human Cannabinoid Receptor CB1 , 2016, Cell.
[42] A. McAinch,et al. Renal effects of chronic pharmacological manipulation of CB2 receptors in rats with diet‐induced obesity , 2016, British journal of pharmacology.
[43] L. Pardo,et al. The pathway of ligand entry from the membrane bilayer to a lipid G protein-coupled receptor , 2016, Scientific Reports.
[44] L. Heitman,et al. The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI‐101 prevents cisplatin‐induced nephrotoxicity , 2016, British journal of pharmacology.
[45] W. Guba,et al. Novel Triazolopyrimidine‐Derived Cannabinoid Receptor 2 Agonists as Potential Treatment for Inflammatory Kidney Diseases , 2016, ChemMedChem.
[46] G. Bruno,et al. Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice. , 2014, Kidney international.
[47] R. Mechoulam,et al. Early phytocannabinoid chemistry to endocannabinoids and beyond , 2014, Nature Reviews Neuroscience.
[48] John Reilly,et al. Observed Drug-Receptor Association Rates Are Governed by Membrane Affinity: The Importance of Establishing “Micro-Pharmacokinetic/Pharmacodynamic Relationships” at the β2-Adrenoceptor , 2014, Molecular Pharmacology.
[49] Hugh Rosen,et al. Crystal Structure of a Lipid G Protein–Coupled Receptor , 2012, Science.
[50] S. Boyce,et al. Discovery and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel class of selective cannabinoid CB2 receptor agonists. , 2011, Journal of medicinal chemistry.
[51] P Pacher,et al. Is lipid signaling through cannabinoid 2 receptors part of a protective system? , 2011, Progress in lipid research.
[52] Stephen P. H. Alexander,et al. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2 , 2010, Pharmacological Reviews.
[53] A. Howlett,et al. CB(1) cannabinoid receptors and their associated proteins. , 2010, Current medicinal chemistry.
[54] P. Emsley,et al. Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.
[55] H. Pan,et al. Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy. , 2010, Free radical biology & medicine.
[56] Randy J. Read,et al. Acta Crystallographica Section D Biological , 2003 .
[57] Vincent B. Chen,et al. Correspondence e-mail: , 2000 .
[58] A. Hohmann,et al. Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain , 2008, British journal of pharmacology.
[59] H. Pan,et al. Cannabinoid‐2 receptor mediates protection against hepatic ischemia/reperfusion injury , 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[60] Daniel Fleischer,et al. Mutation Studies of Ser7.39 and Ser2.60 in the Human CB1 Cannabinoid Receptor: Evidence for a Serine-Induced Bend in CB1 Transmembrane Helix 7 , 2007, Molecular Pharmacology.
[61] R. Copeland,et al. Drug–target residence time and its implications for lead optimization , 2006, Nature Reviews Drug Discovery.
[62] P. Pacher,et al. The Endocannabinoid System as an Emerging Target of Pharmacotherapy , 2006, Pharmacological Reviews.
[63] David N Mastronarde,et al. Automated electron microscope tomography using robust prediction of specimen movements. , 2005, Journal of structural biology.
[64] Conrad C. Huang,et al. UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..
[65] M. Herkenham,et al. International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors , 2002, Pharmacological Reviews.
[66] H. Weinstein,et al. Comparison of the amino acid residues in the sixth transmembrane domains accessible in the binding-site crevices of mu, delta, and kappa opioid receptors. , 2001, Biochemistry.
[67] R. Mechoulam,et al. HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[68] J. Ballesteros,et al. A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice. , 1998, Biochemistry.
[69] B. Martin,et al. Cannabis: pharmacology and toxicology in animals and humans. , 1996, Addiction.
[70] M. Krečmerová,et al. Lipases as Tools in the Synthesis of Prodrugs from Racemic 9-(2,3-Dihydroxypropyl)adenine , 2012, Molecules.
[71] S. Galiègue,et al. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. , 1995, European journal of biochemistry.
[72] S. Munro,et al. Molecular characterization of a peripheral receptor for cannabinoids , 1993, Nature.
[73] H. Okayama,et al. High-efficiency transformation of mammalian cells by plasmid DNA. , 1987, Molecular and cellular biology.
[74] P. K. Smith,et al. Measurement of protein using bicinchoninic acid. , 1985, Analytical biochemistry.
[75] Y. Cheng,et al. Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. , 1973, Biochemical pharmacology.
[76] O. Mock. [Animals and humans]. , 1967, Therapie der Gegenwart.