Ginger From Ancient Times to the New Outlook

Context: Ginger is the rhizome of Zingiber officinale, a perennial plant, used alone or in compounds as a spice or remedy in ancient recipes of Iranian traditional medicine (ITM) as an effective tonic for the memory and digestive system, the opener of hepatic obstructions, aphrodisiac, for expelling compact wind from stomach and intestines, diluting, desiccating and emollient of phlegmatic and compact humor sticking to body organs, stomach, intestine, brain and throat. The ITM scholars believed that ginger was a vermifuge as well as a remedy for paralysis and obstructive jaundice. They also revealed that this phytomedicine cures diarrhea due to corrupted food. This study aimed to compare the medicinal properties (afaal) of ginger in ITM with those indicated in modern research. Results: Results of this study showed that the modern phytotherapy confirmed some of the properties of ginger. In addition, some of the properties of this phytomedicine have not been studied yet. Conclusions: By studding the ITM literature, herb elements or in other words ITM keywords, researchers can predict and state some unknown or less known potential pharmacologic effects of medicinal plants.

[1]  M. Mobasseri,et al.  Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients , 2013, International journal of food sciences and nutrition.

[2]  Shaohui Zong,et al.  Protective effects of ginger root extract on Alzheimer disease-induced behavioral dysfunction in rats. , 2013, Rejuvenation research.

[3]  Kaliyaperumal Karunamoorthi,et al.  Traditional Medicinal Plants , 2013 .

[4]  D. Gang,et al.  Suites of Terpene Synthases Explain Differential Terpenoid Production in Ginger and Turmeric Tissues , 2012, PloS one.

[5]  A. Delazar,et al.  Phytochemistry and bioactivity of Pedicularis sibthorpii growing in Iran , 2012 .

[6]  R. Hafizur,et al.  Antiglycation, antioxidant and toxicological potential of polyphenol extracts of alligator pepper, ginger and nutmeg from Nigeria. , 2012, Asian Pacific journal of tropical biomedicine.

[7]  M. Baliga,et al.  Radioprotective effects of Zingiber officinale Roscoe (ginger): past, present and future. , 2012, Food & function.

[8]  L. Rao,et al.  An Impression on Current Developments in the Technology, Chemistry, and Biological Activities of Ginger (Zingiber officinale Roscoe) , 2012, Critical reviews in food science and nutrition.

[9]  A. Delazar,et al.  Antioxidant and Antimicrobial activity of Pedicularis sibthorpii Boiss. And Pedicularis wilhelmsiana Fisch ex. , 2012, Advanced pharmaceutical bulletin.

[10]  Hanmei Liu,et al.  Effects of Zingiber officinale extract on antioxidation and lipid peroxidation in mice after exposure to 60 Co-γ-ray , 2012 .

[11]  J. De,et al.  Traditional use of medicinal plants as febrifuge by the tribals of Purulia district, West Bengal, India , 2012 .

[12]  Calvin Yu-Chian Chen,et al.  In silico pharmacology suggests ginger extracts may reduce stroke risks. , 2011, Molecular bioSystems.

[13]  M. Baliga,et al.  Zingiber officinale Roscoe (ginger) as an adjuvant in cancer treatment: a review. , 2011, Journal of B.U.ON. : official journal of the Balkan Union of Oncology.

[14]  M. Baliga,et al.  Update on the Chemopreventive Effects of Ginger and its Phytochemicals , 2011, Critical reviews in food science and nutrition.

[15]  R. Eid,et al.  Antischistosomal activity of ginger (Zingiber officinale) against Schistosoma mansoni harbored in C57 mice , 2011, Parasitology Research.

[16]  V. M. Nisha,et al.  Inhibitory potential of ginger extracts against enzymes linked to type 2 diabetes, inflammation and induced oxidative stress , 2011, International journal of food sciences and nutrition.

[17]  S. Sulaiman,et al.  Essential oils of Zingiber officinale var. rubrum Theilade and their antibacterial activities , 2011 .

[18]  S. Arason,et al.  Effects of different pre-salting methods on protein aggregation during heavy salting of cod fillets , 2011 .

[19]  E. Al-Suhaimi,et al.  Physiological and therapeutical roles of ginger and turmeric on endocrine functions. , 2011, The American journal of Chinese medicine.

[20]  M. Ramalingam Health Benefits of Spices with Special Reference to Antimicrobial Activity and Bio Active Components , 2010 .

[21]  Gopal Chakrabarti,et al.  Aqueous extract of ginger shows antiproliferative activity through disruption of microtubule network of cancer cells. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[22]  M. Hou,et al.  6-Dehydrogingerdione, an active constituent of dietary ginger, induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human breast cancer cells. , 2010, Molecular Nutrition & Food Research.

[23]  L. Tiwari,et al.  Ethnoveterinary medicines in Indian perspective: reference to Uttarakhand, Himalaya. , 2010 .

[24]  Yasmin Anum Mohd Yusof,et al.  Ginger extract (Zingiber officinale) triggers apoptosis and G0/G1 cells arrest in HCT 116 and HT 29 colon cancer cell lines. , 2010 .

[25]  Dalia A. Hafez Effect of Extracts of Ginger Goots and Cinnamon Bark on Fertility of Male Diabetic Rats , 2010 .

[26]  R. Ringseis,et al.  Metabolism and actions of conjugated linoleic acids on atherosclerosis-related events in vascular endothelial cells and smooth muscle cells. , 2010, Molecular nutrition & food research.

[27]  A. Khaki Iranian Journal of Reproductive Medicine Vol.7. No.1. pp: 7-12, Winter 2009 The effects of Ginger on spermatogenesis and sperm parameters of rat , 2008 .

[28]  R. Nicoll,et al.  Ginger (Zingiber officinale Roscoe): a hot remedy for cardiovascular disease? , 2009, International journal of cardiology.

[29]  R. Cuman,et al.  Immunomodulatory activity of Zingiber officinale Roscoe, Salvia officinalis L. and Syzygium aromaticum L. essential oils: evidence for humor- and cell-mediated responses. , 2009, The Journal of pharmacy and pharmacology.

[30]  R. Bestetti,et al.  Sudden cardiac death in Chagas' heart disease in the contemporary era. , 2008, International journal of cardiology.

[31]  J. Hasegawa,et al.  Systemic administration of [6]-gingerol, a pungent constituent of ginger, induces hypothermia in rats via an inhibitory effect on metabolic rate. , 2008, European journal of pharmacology.

[32]  A. Nemmar,et al.  Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[33]  P. I. Ushimaru,et al.  Antibacterial activity of medicinal plant extracts , 2007 .

[34]  Samiuela Lee,et al.  Liquid chromatographic determination of 6-, 8-, 10-gingerol, and 6-shogaol in ginger (Zingiber officinale) as the raw herb and dried aqueous extract. , 2007, Journal of AOAC International.

[35]  Yasmin Anum Mohd Yusof,et al.  Antiproliferative, antioxidant and apoptosis effects of Zingiber Officenale and 6-Gingerol on HepG2 cells , 2007 .

[36]  Y. Shukla,et al.  Cancer preventive properties of ginger: a brief review. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[37]  T. A. Gomes,et al.  Expression of aggregative adherence to hela cells by Escherichia coli strains isolated from sick horses , 2007 .

[38]  B. Timmermann,et al.  The effect of extracts from ginger rhizome on inflammatory mediator production. , 2007, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[39]  A. Stoyanova,et al.  Antioxidant activity of a ginger extract (Zingiber officinale) , 2007 .

[40]  A. Cavender Folk medical uses of plant foods in southern Appalachia, United States. , 2006, Journal of ethnopharmacology.

[41]  P. Mukherjee,et al.  Determination of 6-gingerol in ginger (Zingiber officinale) using high-performance thin-layer chromatography. , 2006, Journal of separation science.

[42]  Z. Iqbal,et al.  In vivo anthelmintic activity of ginger against gastrointestinal nematodes of sheep. , 2006, Journal of ethnopharmacology.

[43]  H. Nasri,et al.  Effects of ginger on the improvement of asthma The evaluation of its' treatmental effects , 2006 .

[44]  R. Cuman,et al.  Antiinflammatory and antinociceptive activities of zingiber officinale roscoe essential oil in experimental animal models , 2006 .

[45]  S. Chrubasik,et al.  Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles. , 2005, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[46]  R. Cady,et al.  Gelstat Migraine (sublingually administered feverfew and ginger compound) for acute treatment of migraine when administered during the mild pain phase. , 2005, Medical science monitor : international medical journal of experimental and clinical research.

[47]  B. Timmermann,et al.  Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production. , 2005, Phytochemistry.

[48]  J. Geiger The essential oil of ginger, Zingiber officinale, and anaesthesia , 2005 .

[49]  N. Keawpradub,et al.  Cytotoxic and free radical scavenging activities of Zingiberaceous rhizomes , 2004 .

[50]  M. Ishii,et al.  Diet and Japanese herbal medicine for recalcitrant atopic dermatitis: efficacy and safety. , 2004, Drugs under experimental and clinical research.

[51]  Ling-Ling Yang,et al.  Effects of 6-gingerol, an antioxidant from ginger, on inducing apoptosis in human leukemic HL-60 cells. , 2003, In vivo.

[52]  Yoshimasa Nakamura,et al.  Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells. , 2003, Cancer letters.

[53]  Y. Tsushima,et al.  Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats. , 2003, Cancer letters.

[54]  M. Gbéassor,et al.  Bioassay‐guided isolation and identification of antifungal compounds from ginger , 2003, Phytotherapy research : PTR.

[55]  K. Oguchi,et al.  Increase in plasma fibrinogen and plasminogen activator inhibitor level in diabetic KK and KK-Ay mice. , 2003, In vivo.

[56]  R. Altman,et al.  Effects of a ginger extract on knee pain in patients with osteoarthritis. , 2001, Arthritis and rheumatism.

[57]  G. Milne,et al.  Separation and identification of phospholipid peroxidation products , 2001, Lipids.

[58]  D. A. Golden,et al.  Antimicrobial activity of essential oils from plants against selected pathogenic and saprophytic microorganisms. , 2001, Journal of food protection.

[59]  M. Menon,,et al.  Ginger: An Ethnomedical, Chemical and Pharmacological Review , 2001, Drug metabolism and drug interactions.

[60]  R. Coleman,et al.  Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice. , 2000, The Journal of nutrition.

[61]  K. Naidu,et al.  Antioxidant activity of selected Indian spices. , 2000, Prostaglandins, leukotrienes, and essential fatty acids.

[62]  J. Yamahara,et al.  [Stomachic principles in ginger. II. Pungent and anti-ulcer effects of low polar constituents isolated from ginger, the dried rhizoma of Zingiber officinale Roscoe cultivated in Taiwan. The absolute stereostructure of a new diarylheptanoid]. , 1992, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[63]  K. C. Srivastava,et al.  Ginger (Zingiber officinale) and rheumatic disorders. , 1989, Medical hypotheses.

[64]  F. Sakamura Changes in volatile constituents of Zingiber officinale rhizomes during storage and cultivation , 1987 .

[65]  K. C. Srivastava Effects of aqueous extracts of onion, garlic and ginger on platelet aggregation and metabolism of arachidonic acid in the blood vascular system: in vitro study , 1984 .

[66]  W. Lands Biological consequences of fatty acid oxygenase reaction mechanisms. , 1984, Prostaglandins, leukotrienes, and medicine.

[67]  K. C. Srivas Effects of aqueous extracts of onion, garlic and ginger on platelet aggregation and metabolism of arachidonic acid in the blood vascular system: in vitro study. , 1984, Prostaglandins, leukotrienes, and medicine.

[68]  D. Holdsworth,et al.  Traditional Medicinal Plants of New Ireland, Papua New Guinea , 1980 .