Self-Sensing Scanning Superlens for Three-Dimensional Noninvasive Visible-Light Nanoscale Imaging on Complex Surfaces.

Microsphere-assisted super-resolution imaging technology offers label-free, real-time dynamic imaging via white light, which has potential applications in living systems and the nanoscale detection of semiconductor chips. Scanning can aid in overcoming the limitations of the imaging area of a single microsphere superlens. However, the current scanning imaging method based on the microsphere superlens cannot achieve super-resolution optical imaging of complex curved surfaces. Unfortunately, most natural surfaces are composed of complex curved surfaces at the microscale. In this study, we developed a method to overcome this limitation through a microsphere superlens with a feedback capability. By maintaining a constant force between the microspheres and the sample, noninvasive super-resolution optical imaging of complex abiotic and biological surfaces was achieved, and the three-dimensional information on the sample was simultaneously obtained. The proposed method significantly expands the universality of scanning microsphere superlenses for samples and promotes their widespread use.

[1]  Yuechao Wang,et al.  Correlative AFM and Scanning Microlens Microscopy for Time‐Efficient Multiscale Imaging , 2022, Advanced science.

[2]  Yunje Cho,et al.  Microsphere-assisted, nanospot, non-destructive metrology for semiconductor devices , 2022, Light, science & applications.

[3]  J. Rho,et al.  Electrically Tunable Bifocal Metalens with Diffraction‐Limited Focusing and Imaging at Visible Wavelengths , 2021, Advanced science.

[4]  Lin Li,et al.  Novel N-doped graphene enhanced ultrafiltration nano-porous polyvinylidene fluoride membrane with high permeability and stability for water treatment , 2021, Separation and Purification Technology.

[5]  Weidong Yang,et al.  High-speed super-resolution imaging of rotationally symmetric structures using SPEED microscopy and 2D-to-3D transformation , 2020, Nature Protocols.

[6]  Lianqing Liu,et al.  Scanning Super-resolution Imaging in Enclosed Environment by Laser Tweezer Controlled Superlens. , 2020, Biophysical journal.

[7]  T. Huang,et al.  Acoustofluidic Scanning Nanoscope with High Resolution and Large Field of View. , 2020, ACS nano.

[8]  P. Fratzl,et al.  Author Correction: Hierarchically-structured metalloprotein composite coatings biofabricated from co-existing condensed liquid phases , 2020, Nature Communications.

[9]  Yuchao Li,et al.  Single-cell biomagnifier for optical nanoscopes and nanotweezers , 2019, Light: Science & Applications.

[10]  M. Hong,et al.  Microsphere enhanced optical imaging and patterning: From physics to applications , 2019, Applied Physics Reviews.

[11]  M. Gijs,et al.  Turning a normal microscope into a super-resolution instrument using a scanning microlens array , 2018, Scientific Reports.

[12]  J. Rho,et al.  Realization of Wafer-Scale Hyperlens Device for Sub-diffractional Biomolecular Imaging , 2017 .

[13]  Mingjie Liu,et al.  Nature-inspired superwettability systems , 2017 .

[14]  Alberto Diaspro,et al.  Combination of scanning probe technology with photonic nanojets , 2017, Scientific Reports.

[15]  Stanislav N. Gorb,et al.  Bioinspired photocontrollable microstructured transport device , 2017, Science Robotics.

[16]  Lianqing Liu,et al.  Scanning superlens microscopy for non-invasive large field-of-view visible light nanoscale imaging , 2016, Nature Communications.

[17]  Joseph Wang,et al.  Swimming Microrobot Optical Nanoscopy. , 2016, Nano letters.

[18]  Martin A M Gijs,et al.  Super-Resolution Imaging of a Dielectric Microsphere Is Governed by the Waist of Its Photonic Nanojet. , 2016, Nano letters.

[19]  A. Urbas,et al.  Movable thin films with embedded high-index microspheres for super-resolution microscopy , 2015, 1508.05663.

[20]  J. Auwerx,et al.  Super-resolution biological microscopy using virtual imaging by a microsphere nanoscope. , 2014, Small.

[21]  Arash Darafsheh,et al.  Advantages of microsphere-assisted super-resolution imaging technique over solid immersion lens and confocal microscopies , 2014 .

[22]  Minghui Hong,et al.  Microsphere-coupled scanning laser confocal nanoscope for sub-diffraction-limited imaging at 25 nm lateral resolution in the visible spectrum. , 2014, ACS nano.

[23]  Tao Wang,et al.  Label-free super-resolution imaging of adenoviruses by submerged microsphere optical nanoscopy , 2013, Light: Science & Applications.

[24]  Zengbo Wang,et al.  Locomotion of microspheres for super-resolution imaging , 2013, Scientific Reports.

[25]  Sindy K. Y. Tang,et al.  Bioinspired self-repairing slippery surfaces with pressure-stable omniphobicity , 2011, Nature.

[26]  Zhaowei Liu,et al.  Spherical hyperlens for two-dimensional sub-diffractional imaging at visible frequencies. , 2010, Nature communications.

[27]  M. Hong,et al.  The optical microscopy with virtual image breaks a record: 50-nm resolution imaging is demonstrated , 2010, 1006.4037.

[28]  M. Gustafsson,et al.  Subdiffraction Multicolor Imaging of the Nuclear Periphery with 3D Structured Illumination Microscopy , 2008, Science.

[29]  D. Mcmullan.  Scanning electron microscopy 1928–1965† , 2006 .

[30]  Sverre Myhra,et al.  Scanning force microscopy - Calibrative procedures for 'best practice' , 2006 .

[31]  Michael J Rust,et al.  Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM) , 2006, Nature Methods.

[32]  J. Lippincott-Schwartz,et al.  Imaging Intracellular Fluorescent Proteins at Nanometer Resolution , 2006, Science.

[33]  Jin Zhai,et al.  A lotus-leaf-like superhydrophobic surface: a porous microsphere/nanofiber composite film prepared by electrohydrodynamics. , 2004, Angewandte Chemie.

[34]  J. Sambles,et al.  Photonic structures in biology , 2003, Nature.

[35]  E. Betzig,et al.  Near-Field Optics: Microscopy, Spectroscopy, and Surface Modification Beyond the Diffraction Limit , 1992, Science.

[36]  T. D. Harris,et al.  Breaking the Diffraction Barrier: Optical Microscopy on a Nanometric Scale , 1991, Science.