Esterase activity in porcine and albino rabbit ocular tissues

[1]  A. Urtti,et al.  Implications of melanin binding in ocular drug delivery☆ , 2017, Advanced drug delivery reviews.

[2]  H. Kidron,et al.  Expression, activity and pharmacokinetic impact of ocular transporters☆ , 2017, Advanced drug delivery reviews.

[3]  A. Urtti,et al.  Hyaluronic Acid Graft Copolymers with Cleavable Arms as Potential Intravitreal Drug Delivery Vehicles. , 2018, Macromolecular bioscience.

[4]  A. Urtti,et al.  Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts , 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[5]  U. Argikar,et al.  Do We Need to Study Metabolism and Distribution in the Eye: Why, When, and Are We There Yet? , 2017, Journal of pharmaceutical sciences.

[6]  A. Urtti,et al.  Differentially cleaving peptides as a strategy for controlled drug release in human retinal pigment epithelial cells , 2017, Journal of controlled release : official journal of the Controlled Release Society.

[7]  B. Pierscionek,et al.  Age‐related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens , 2015, The Journal of pharmacy and pharmacology.

[8]  C. Struble,et al.  Comparison of ocular tissue weights (volumes) and tissue collection techniques in commonly used preclinical animal species. , 2014 .

[9]  Edward J Kelly,et al.  Ocular cytochrome P450s and transporters: roles in disease and endobiotic and xenobiotic disposition , 2014, Drug metabolism reviews.

[10]  Y. Fukano,et al.  Disposition and Metabolism of a Novel Prostanoid Antiglaucoma Medication, Tafluprost, Following Ocular Administration to Rats , 2009, Drug Metabolism and Disposition.

[11]  G. Amidon,et al.  Nucleoside Ester Prodrug Substrate Specificity of Liver Carboxylesterase , 2006, Journal of Pharmacology and Experimental Therapeutics.

[12]  S. Majumdar,et al.  Role of metabolism in ocular drug delivery. , 2004, Current drug metabolism.

[13]  A. Mitra,et al.  Ocular disposition of novel lipophilic diester prodrugs of ganciclovir following intravitreal administration using microdialysis , 2004, Current eye research.

[14]  S. Coupland,et al.  Hydrolases of anterior segment tissues in the normal human, pig and rat eye: a comparative study , 1994, Graefe's Archive for Clinical and Experimental Ophthalmology.

[15]  P. Klimko,et al.  The hydrolysis of the prostaglandin analog prodrug bimatoprost to 17-phenyl-trinor PGF2alpha by human and rabbit ocular tissue. , 2003, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

[16]  B. Yan,et al.  Human and rodent carboxylesterases: immunorelatedness, overlapping substrate specificity, differential sensitivity to serine enzyme inhibitors, and tumor-related expression. , 2002, Drug metabolism and disposition: the biological fate of chemicals.

[17]  A. Mitra,et al.  Effect of mono- and di-acylation on the ocular disposition of ganciclovir: physicochemical properties, ocular bioreversion, and antiviral activity of short chain ester prodrugs. , 2002, Journal of pharmaceutical sciences.

[18]  S. Basu,et al.  The pharmacokinetics of a new antiglaucoma drug, latanoprost, in the rabbit. , 1998, Drug metabolism and disposition: the biological fate of chemicals.

[19]  I. Constable,et al.  Modulation of cathepsin D activity in retinal pigment epithelial cells. , 1997, The Biochemical journal.

[20]  M. Nakamura,et al.  Characterization of esterases involved in the hydrolysis of dipivefrin hydrochloride. , 1993, Ophthalmic research.

[21]  V. H. Lee,et al.  Improved corneal penetration of timolol by prodrugs as a means to reduce systemic drug load. , 1987, Investigative ophthalmology & visual science.

[22]  S. C. Chang,et al.  Ocular esterase composition in albino and pigmented rabbits: possible implications in ocular prodrug design and evaluation. , 1985, Current eye research.

[23]  V. H. Lee,et al.  The role of esterase activity in the ocular disposition of dipivalyl epinephrine in rabbits , 1983 .

[24]  V. H. Lee Esterase activities in adult rabbit eyes. , 1983, Journal of pharmaceutical sciences.

[25]  V. H. Lee,et al.  Esterase distribution in the rabbit cornea and its implications in ocular drug bioavailability. , 1982, Biopharmaceutics & drug disposition.

[26]  V. H. Lee,et al.  Subcellular distribution of esterases in the bovine eye. , 1982, Current eye research.

[27]  V. H. Lee,et al.  Influence of chain length on the in vitro hydrolysis of model ester prodrugs by ocular esterases. , 1982, Current eye research.

[28]  W. L. Davis,et al.  Site of ocular hydrolysis of a prodrug, dipivefrin, and a comparison of its ocular metabolism with that of the parent compound, epinephrine. , 1980, Investigative ophthalmology & visual science.

[29]  A. Kitabchi,et al.  Dipivalyl epinephrine: a new pro-drug in the treatment of glaucoma. , 1978, Ophthalmology.

[30]  M. M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.