Running head : Platelets suppress lymphangiogenesis in colitis

Platelet interaction with lymphatics aggravates intestinal inflammation by suppressing 1 lymphangiogenesis 2 3 Running head: Platelets suppress lymphangiogenesis in colitis 4 5 Hirokazu Sato, Masaaki Higashiyama, Hideaki Hozumi, Shingo Sato, Hirotaka 6 Furuhashi, Takeshi Takajyo, Koji Maruta, Yuichi Yasutake, Kazuyuki Narimatsu, 7 Kenichi Yoshikawa, Chie Kurihara, Yoshikiyo Okada, Chikako Watanabe, Shunsuke 8 Komoto, Kengo Tomita, Shigeaki Nagao, Soichiro Miura, Ryota Hokari. 9 10 1 Department of Internal medicine, National Defense Medical College, Saitama, Japan 11 2 National Defense Medical College, Saitama, Japan 12 13 Corresponding author: Ryota Hokari 14 e-mail: ryota@ndmc.ac.jp 15 Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, 16 Tokorozawa, Saitama, Japan. 359-8513 17 Tel: +81-4-2995-1609, FAX: +81-4-2996-5201 18 19 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (June 16, 2016). doi:10.1152/ajpgi.00455.2015

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