Structural insights into the mode of action of a pure antiestrogen.
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M Carlquist | R E Hubbard | A M Brzozowski | J. Gustafsson | R. Hubbard | A. Brzozowski | A. Pike | M. Carlquist | A. Thorsell | J A Gustafsson | A C Pike | J. Walton | J Walton | A G Thorsell | Y L Li | J. Gustafsson | Yi-Lin Li | Y. L. Li
[1] C. Glass,et al. Coactivator and corepressor complexes in nuclear receptor function. , 1999, Current opinion in genetics & development.
[2] Thorsten Heinzel,et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor , 1995, Nature.
[3] Collaborative Computational,et al. The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.
[4] J. Thornton,et al. PROCHECK: a program to check the stereochemical quality of protein structures , 1993 .
[5] P. Argos,et al. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A , 1986, Nature.
[6] H. Pols,et al. Distinct effects on the conformation of estrogen receptor alpha and beta by both the antiestrogens ICI 164,384 and ICI 182,780 leading to opposite effects on receptor stability. , 1999, Biochemical and biophysical research communications.
[7] D. Williams,et al. Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized rats. , 1994, The Journal of clinical investigation.
[8] R. Lanz,et al. Nuclear receptor coregulators: cellular and molecular biology. , 1999, Endocrine reviews.
[9] R J Fletterick,et al. Structure and specificity of nuclear receptor-coactivator interactions. , 1998, Genes & development.
[10] A. Wakeling,et al. Novel steroidal pure antiestrogens , 1989, Steroids.
[11] J. Gustafsson,et al. Differential response of estrogen receptor alpha and estrogen receptor beta to partial estrogen agonists/antagonists. , 1998, Molecular pharmacology.
[12] T. Willson,et al. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ , 1998, Nature.
[13] H Grøn,et al. Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[14] J. Gustafsson,et al. Cloning of a novel receptor expressed in rat prostate and ovary. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[15] M. Lazar,et al. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors , 1999, Nature.
[16] B. O’Malley,et al. Molecular mechanisms of action of steroid/thyroid receptor superfamily members. , 1994, Annual review of biochemistry.
[17] H. Gronemeyer,et al. The nuclear receptor ligand-binding domain: structure and function. , 1998, Current opinion in cell biology.
[18] Zbigniew Dauter,et al. Molecular basis of agonism and antagonism in the oestrogen receptor , 1997, Nature.
[19] M Carlquist,et al. Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist , 1999, The EMBO journal.
[20] A. Wakeling,et al. A potent specific pure antiestrogen with clinical potential. , 1991, Cancer research.
[21] B. Katzenellenbogen,et al. Ligand-dependent, transcriptionally productive association of the amino- and carboxyl-terminal regions of a steroid hormone nuclear receptor. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[22] C. Glass,et al. Molecular determinants of nuclear receptor-corepressor interaction. , 1999, Genes & development.
[23] N. Webster,et al. The human estrogen receptor has two independent nonacidic transcriptional activation functions , 1989, Cell.
[24] K.,et al. Diverse signaling pathways modulate nuclear receptor recruitment of N-CoR and SMRT complexes. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[25] Daniel Metzger,et al. Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase , 1995, Science.
[26] G. Murshudov,et al. Refinement of macromolecular structures by the maximum-likelihood method. , 1997, Acta crystallographica. Section D, Biological crystallography.
[27] E A Merritt,et al. Raster3D: photorealistic molecular graphics. , 1997, Methods in enzymology.
[28] R. Evans,et al. The steroid and thyroid hormone receptor superfamily. , 1988, Science.
[29] J. Lees,et al. Identification of a conserved region required for hormone dependent transcriptional activation by steroid hormone receptors. , 1992, The EMBO journal.
[30] P B Sigler,et al. Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[31] M. Parker,et al. Molecular Determinants of the Estrogen Receptor-Coactivator Interface , 1999, Molecular and Cellular Biology.
[32] B. Katzenellenbogen,et al. Transcription Activation by the Human Estrogen Receptor Subtypeβ (ERβ) Studied with ERβ and ERα Receptor Chimeras* *This work was supported by NIH Grants CA-18119 and CA-60514 (to B.S.K.). , 1998, Endocrinology.
[33] S. Fawell,et al. Identification of two transactivation domains in the mouse oestrogen receptor. , 1989, Nucleic acids research.
[34] David A. Agard,et al. The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen , 1998, Cell.
[35] P. Chambon,et al. The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function , 1988, Cell.
[36] A. Howell,et al. Response to a specific antioestrogen (ICI 182780) in tamoxifen-resistant breast cancer , 1995, The Lancet.
[37] K. Grandien,et al. Printed in U.S.A. Copyright © 1997 by The Endocrine Society Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors � and � , 2022 .
[38] V. Jordan,et al. Basic guide to the mechanisms of antiestrogen action. , 1998, Pharmacological reviews.
[39] Z. Otwinowski,et al. [20] Processing of X-ray diffraction data collected in oscillation mode. , 1997, Methods in enzymology.
[40] M. Parker,et al. Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[41] S. Fawell,et al. Inhibition of estrogen receptor-DNA binding by the "pure" antiestrogen ICI 164,384 appears to be mediated by impaired receptor dimerization. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[42] M. Tzukerman,et al. Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions. , 1994, Molecular endocrinology.
[43] R M Esnouf,et al. An extensively modified version of MolScript that includes greatly enhanced coloring capabilities. , 1997, Journal of molecular graphics & modelling.
[44] A. Mahfoudi,et al. Specific mutations in the estrogen receptor change the properties of antiestrogens to full agonists. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[45] M. Parker,et al. The antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttling. , 1993, Journal of cell science.
[46] Axel T. Brunger,et al. X-PLOR Version 3.1: A System for X-ray Crystallography and NMR , 1992 .
[47] J M Thornton,et al. LIGPLOT: a program to generate schematic diagrams of protein-ligand interactions. , 1995, Protein engineering.
[48] J. Pike,et al. Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens. , 1995, Molecular endocrinology.
[49] D. Fowlkes,et al. Comparative Analyses of Mechanistic Differences Among Antiestrogens1. , 1999, Endocrinology.
[50] R. Evans,et al. Mechanism of corepressor binding and release from nuclear hormone receptors. , 1999, Genes & development.
[51] R J Fletterick,et al. Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors. , 1998, Science.