Activation of superoxide dismutases: putting the metal to the pedal.

[1]  T. O’Halloran,et al.  Posttranslational modifications in Cu,Zn-superoxide dismutase and mutations associated with amyotrophic lateral sclerosis. , 2006, Antioxidants & redox signaling.

[2]  E. Bigio,et al.  Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[3]  T. Siddique,et al.  Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[4]  D. Winge,et al.  The effects of mitochondrial iron homeostasis on cofactor specificity of superoxide dismutase 2 , 2006, The EMBO journal.

[5]  P. Andersen,et al.  Disulphide-reduced superoxide dismutase-1 in CNS of transgenic amyotrophic lateral sclerosis models. , 2006, Brain : a journal of neurology.

[6]  M. Ushio-Fukai,et al.  Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress , 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[7]  D. Borchelt,et al.  Mapping superoxide dismutase 1 domains of non‐native interaction: roles of intra‐ and intermolecular disulfide bonding in aggregation , 2006, Journal of neurochemistry.

[8]  J. W. Whittaker,et al.  Kinetic analysis of the metal binding mechanism of Escherichia coli manganese superoxide dismutase. , 2006, Biophysical journal.

[9]  L. T. Jensen,et al.  Activation of CuZn Superoxide Dismutases from Caenorhabditis elegans Does Not Require the Copper Chaperone CCS* , 2005, Journal of Biological Chemistry.

[10]  N. Robinson,et al.  Understanding how cells allocate metals using metal sensors and metallochaperones. , 2005, Accounts of chemical research.

[11]  Bryan F. Shaw,et al.  Destabilization of apoprotein is insufficient to explain Cu,Zn-superoxide dismutase-linked ALS pathogenesis. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[12]  E. Luk,et al.  Manganese Activation of Superoxide Dismutase 2 in the Mitochondria of Saccharomyces cerevisiae* , 2005, Journal of Biological Chemistry.

[13]  J. Valentine,et al.  Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis. , 2005, Annual review of biochemistry.

[14]  S. Werner,et al.  Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. , 2005, Free radical biology & medicine.

[15]  E. Baumgart-Vogt,et al.  Peroxiredoxins, oxidative stress, and cell proliferation. , 2005, Antioxidants & redox signaling.

[16]  T. O’Halloran,et al.  Amyotrophic Lateral Sclerosis Mutations Have the Greatest Destabilizing Effect on the Apo- and Reduced Form of SOD1, Leading to Unfolding and Oxidative Aggregation* , 2005, Journal of Biological Chemistry.

[17]  D. Harrison,et al.  Role of Antioxidant-1 in Extracellular Superoxide Dismutase Function and Expression , 2005, Circulation research.

[18]  M. Beal,et al.  Mutant Superoxide Dismutase 1 Forms Aggregates in the Brain Mitochondrial Matrix of Amyotrophic Lateral Sclerosis Mice , 2005, The Journal of Neuroscience.

[19]  D. Richardson,et al.  Iron trafficking in the mitochondrion: novel pathways revealed by disease. , 2005, Blood.

[20]  C. Epstein,et al.  CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life , 2005, Oncogene.

[21]  Borries Demeler,et al.  Dissociation of Human Copper-Zinc Superoxide Dismutase Dimers Using Chaotrope and Reductant , 2004, Journal of Biological Chemistry.

[22]  I. Bertini,et al.  The Unusually Stable Quaternary Structure of Human Cu,Zn-Superoxide Dismutase 1 Is Controlled by Both Metal Occupancy and Disulfide Status* , 2004, Journal of Biological Chemistry.

[23]  Nikolay V Dokholyan,et al.  The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[24]  D. Kurtz.  Microbial detoxification of superoxide: the non-heme iron reductive paradigm for combating oxidative stress. , 2004, Accounts of chemical research.

[25]  O. Carugo,et al.  Unique Features of the sodC-encoded Superoxide Dismutase from Mycobacterium tuberculosis, a Fully Functional Copper-containing Enzyme Lacking Zinc in the Active Site* , 2004, Journal of Biological Chemistry.

[26]  T. O’Halloran,et al.  Oxygen‐induced maturation of SOD1: a key role for disulfide formation by the copper chaperone CCS , 2004, The EMBO journal.

[27]  Ole Gredal,et al.  Toxicity of Familial ALS-Linked SOD1 Mutants from Selective Recruitment to Spinal Mitochondria , 2004, Neuron.

[28]  John A Tainer,et al.  Nickel superoxide dismutase structure and mechanism. , 2004, Biochemistry.

[29]  J. W. Whittaker,et al.  Calorimetric Studies on the Tight Binding Metal Interactions of Escherichia coli Manganese Superoxide Dismutase* , 2004, Journal of Biological Chemistry.

[30]  L. Bruijn,et al.  Unraveling the mechanisms involved in motor neuron degeneration in ALS. , 2004, Annual review of neuroscience.

[31]  Timothy A. Jackson,et al.  Combined spectroscopic/computational studies on Fe- and Mn-dependent superoxide dismutases: insights into second-sphere tuning of active site properties. , 2004, Accounts of chemical research.

[32]  J. Valentine,et al.  Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[33]  T. O’Halloran,et al.  Oxygen and the copper chaperone CCS regulate posttranslational activation of Cu,Zn superoxide dismutase. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[34]  D. Winge,et al.  Yeast Contain a Non-proteinaceous Pool of Copper in the Mitochondrial Matrix* , 2004, Journal of Biological Chemistry.

[35]  A. C. May,et al.  Specificity and Phenetic Relationships of Iron- and Manganese-containing Superoxide Dismutases on the Basis of Structure and Sequence Comparisons* , 2004, Journal of Biological Chemistry.

[36]  J. Reusch,et al.  Role for Oxidative Stress in the Regeneration of Islet Beta Cells? , 2004, Journal of Investigative Medicine.

[37]  C. Epstein,et al.  Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. , 2003, Physiological genomics.

[38]  S. Kardinahl,et al.  Iron superoxide dismutases: structure and function of an archaic enzyme. , 2003, Biochemical Society transactions.

[39]  J. W. Whittaker.  The irony of manganese superoxide dismutase. , 2003, Biochemical Society transactions.

[40]  A. Paul,et al.  A Sod2 null mutation confers severely reduced adult life span in Drosophila. , 2003, Genetics.

[41]  J. Crapo,et al.  The dual nature of human extracellular superoxide dismutase: One sequence and two structures , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[42]  Y. Ho,et al.  Alcohol‐induced liver injury in mice lacking Cu, Zn‐superoxide dismutase , 2003, Hepatology.

[43]  A. Mondragón,et al.  Molecular Basis of Metal-Ion Selectivity and Zeptomolar Sensitivity by CueR , 2003, Science.

[44]  J. Gitlin,et al.  Mechanisms of Biosynthesis of Mammalian Copper/Zinc Superoxide Dismutase* , 2003, Journal of Biological Chemistry.

[45]  N. Brown‐Peterson,et al.  Replacement of a cytosolic copper/zinc superoxide dismutase by a novel cytosolic manganese superoxide dismutase in crustaceans that use copper (haemocyanin) for oxygen transport. , 2003, The Biochemical journal.

[46]  V. Culotta,et al.  Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a member of the mitochondrial carrier family , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[47]  T. O’Halloran,et al.  Factors Controlling the Uptake of Yeast Copper/Zinc Superoxide Dismutase into Mitochondria* , 2003, Journal of Biological Chemistry.

[48]  Thomas V. O'Halloran,et al.  Transition Metal Speciation in the Cell: Insights from the Chemistry of Metal Ion Receptors , 2003, Science.

[49]  M. Savolainen,et al.  The signal sequence polymorphism of the MnSOD gene is associated with the degree of carotid atherosclerosis. , 2003, Atherosclerosis.

[50]  E. Avvedimento,et al.  PKA-dependent binding of mRNA to the mitochondrial AKAP121 protein. , 2003, Journal of molecular biology.

[51]  J. Valentine,et al.  Misfolded CuZnSOD and amyotrophic lateral sclerosis , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[52]  A. Hilliker,et al.  RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[53]  L. Barbeito,et al.  CCS knockout mice establish an alternative source of copper for SOD in ALS. , 2002, Free radical biology & medicine.

[54]  V. Culotta,et al.  Copper Chaperones: Personal Escorts for Metal Ions , 2002, Journal of bioenergetics and biomembranes.

[55]  M. Beal,et al.  Mutated Human SOD1 Causes Dysfunction of Oxidative Phosphorylation in Mitochondria of Transgenic Mice* , 2002, The Journal of Biological Chemistry.

[56]  I. Fridovich,et al.  Amyotrophic lateral sclerosis: A proposed mechanism , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[57]  Jeffrey Rothstein,et al.  Mutant SOD1 causes motor neuron disease independent of copper chaperone–mediated copper loading , 2002, Nature Neuroscience.

[58]  Zuoshang Xu,et al.  Mutant Cu, Zn Superoxide Dismutase that Causes Motoneuron Degeneration Is Present in Mitochondria in the CNS , 2002, The Journal of Neuroscience.

[59]  Antoine Margeot,et al.  Genome‐wide analysis of mRNAs targeted to yeast mitochondria , 2002, EMBO reports.

[60]  V. Culotta,et al.  Manganese Superoxide Dismutase in Saccharomyces cerevisiae Acquires Its Metal Co-factor through a Pathway Involving the Nramp Metal Transporter, Smf2p* , 2001, The Journal of Biological Chemistry.

[61]  G. Lubec,et al.  Protein expression in Down syndrome brain , 2001, Amino Acids.

[62]  Y. Bourbonnais,et al.  Candida albicans Expresses an Unusual Cytoplasmic Manganese-containing Superoxide Dismutase (SOD3 Gene Product) upon the Entry and during the Stationary Phase* , 2001, The Journal of Biological Chemistry.

[63]  L. T. Jensen,et al.  A fraction of yeast Cu,Zn-superoxide dismutase and its metallochaperone, CCS, localize to the intermembrane space of mitochondria. A physiological role for SOD1 in guarding against mitochondrial oxidative damage. , 2001, The Journal of biological chemistry.

[64]  J. Holstege,et al.  CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations , 2001, Acta Neuropathologica.

[65]  A. Lamb,et al.  Heterodimeric structure of superoxide dismutase in complex with its metallochaperone , 2001, Nature Structural Biology.

[66]  P. Langford,et al.  A Novel Heme Protein, the Cu,Zn-Superoxide Dismutase from Haemophilus ducreyi * , 2001, The Journal of Biological Chemistry.

[67]  T. Rouault,et al.  Iron on the brain , 2001, Nature Genetics.

[68]  C. Outten,et al.  Femtomolar Sensitivity of Metalloregulatory Proteins Controlling Zinc Homeostasis , 2001, Science.

[69]  T. O’Halloran,et al.  Mechanism of Cu,Zn-Superoxide Dismutase Activation by the Human Metallochaperone hCCS * , 2001, The Journal of Biological Chemistry.

[70]  A. Rosenzweig,et al.  Copper delivery by metallochaperone proteins. , 2001, Accounts of chemical research.

[71]  E. Cadenas,et al.  Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space. , 2001, The Biochemical journal.

[72]  I. Fridovich,et al.  Copper- and Zinc-containing Superoxide Dismutase Can Act as a Superoxide Reductase and a Superoxide Oxidase* , 2000, The Journal of Biological Chemistry.

[73]  V. Culotta,et al.  Copper Activation of Superoxide Dismutase 1 (SOD1) in Vivo , 2000, The Journal of Biological Chemistry.

[74]  J. Valentine,et al.  Yeast Lacking Superoxide Dismutase(s) Show Elevated Levels of “Free Iron” as Measured by Whole Cell Electron Paramagnetic Resonance* , 2000, The Journal of Biological Chemistry.

[75]  T. O’Halloran,et al.  Metallochaperones, an Intracellular Shuttle Service for Metal Ions* , 2000, The Journal of Biological Chemistry.

[76]  J. Walker,et al.  Identification and functions of new transporters in yeast mitochondria. , 2000, Biochimica et biophysica acta.

[77]  K. Davies,et al.  Mitochondrial free radical generation, oxidative stress, and aging. , 2000, Free radical biology & medicine.

[78]  D L Price,et al.  Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[79]  J. W. Whittaker,et al.  Thermally Triggered Metal Binding by Recombinant Thermus thermophilus Manganese Superoxide Dismutase, Expressed as the Apo-enzyme* , 1999, The Journal of Biological Chemistry.

[80]  R. Salvi,et al.  Age-related cochlear hair cell loss is enhanced in mice lacking copper/zinc superoxide dismutase , 1999, Neurobiology of Aging.

[81]  C. Epstein,et al.  Mitochondrial disease in superoxide dismutase 2 mutant mice. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[82]  M. Matzuk,et al.  Ovarian function in superoxide dismutase 1 and 2 knockout mice. , 1998, Endocrinology.

[83]  A. Nanji,et al.  Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil , 1998, Hepatology.

[84]  A. Dancis.  Genetic analysis of iron uptake in the yeast Saccharomyces cerevisiae. , 1998, The Journal of pediatrics.

[85]  Anne‐Frances Miller,et al.  A Simple Proposal That Can Explain the Inactivity of Metal-Substituted Superoxide Dismutases , 1998 .

[86]  G. Hunter,et al.  Cloning, Expression, and Characterization of Two Manganese Superoxide Dismutases from Caenorhabditis elegans * , 1997, The Journal of Biological Chemistry.

[87]  R. Casareno,et al.  The Copper Chaperone for Superoxide Dismutase* , 1997, The Journal of Biological Chemistry.

[88]  M. Gurney,et al.  The Copper Chelator d‐Penicillamine Delays Onset of Disease and Extends Survival in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis , 1997, The European journal of neuroscience.

[89]  I. Fridovich,et al.  The copper- and zinc-containing superoxide dismutase from Escherichia coli: molecular weight and stability. , 1997, Archives of biochemistry and biophysics.

[90]  M. Matzuk,et al.  Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[91]  M. Beal,et al.  Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury , 1996, Nature Genetics.

[92]  H. Steinman,et al.  Periplasmic copper-zinc superoxide dismutase of Legionella pneumophila: role in stationary-phase survival , 1996, Journal of bacteriology.

[93]  C. Epstein,et al.  Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase , 1995, Nature Genetics.

[94]  S. Marklund,et al.  The interstitium of the human arterial wall contains very large amounts of extracellular superoxide dismutase. , 1995, Arteriosclerosis, thrombosis, and vascular biology.

[95]  G. Rotilio,et al.  Isolation of an active and heat‐stable monomeric form of Cu,Zn superoxide dismutase from the periplasmic space of Escherichia coli , 1995, FEBS letters.

[96]  T. Kwan,et al.  Nramp defines a family of membrane proteins. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[97]  P. Langford,et al.  Bacterial [Cu,Zn]-superoxide dismutase: phylogenetically distinct from the eukaryotic enzyme, and not so rare after all! , 1995, Microbiology.

[98]  I. Fridovich,et al.  Copper, zinc superoxide dismutase in Escherichia coli: periplasmic localization. , 1995, Archives of biochemistry and biophysics.

[99]  D. Borchelt,et al.  Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[100]  M Bolognesi,et al.  Conserved patterns in the Cu,Zn superoxide dismutase family. , 1994, Journal of molecular biology.

[101]  P. L. Larsen.  Aging and resistance to oxidative damage in Caenorhabditis elegans. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[102]  Y. Moriwaki,et al.  Purification and immunohistochemical tissue localization of human xanthine oxidase. , 1993, Biochimica et biophysica acta.

[103]  J. Haines,et al.  Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis , 1993, Nature.

[104]  N. Taniguchi,et al.  Site-specific and random fragmentation of Cu,Zn-superoxide dismutase by glycation reaction. Implication of reactive oxygen species. , 1992, The Journal of biological chemistry.

[105]  A J Sinskey,et al.  Oxidized redox state of glutathione in the endoplasmic reticulum. , 1992, Science.

[106]  I. Fridovich,et al.  Transcriptional and maturational effects of manganese and iron on the biosynthesis of manganese-superoxide dismutase in Escherichia coli. , 1992, The Journal of biological chemistry.

[107]  I. Fridovich,et al.  In vivo competition between iron and manganese for occupancy of the active site region of the manganese-superoxide dismutase of Escherichia coli. , 1991, The Journal of biological chemistry.

[108]  J. Crapo,et al.  Molecular immunocytochemistry of the CuZn superoxide dismutase in rat hepatocytes , 1988, The Journal of cell biology.

[109]  N. Taniguchi,et al.  Increase in the glucosylated form of erythrocyte Cu-Zn-superoxide dismutase in diabetes and close association of the nonenzymatic glucosylation with the enzyme activity. , 1987, Biochimica et biophysica acta.

[110]  K. Asayama,et al.  Rat superoxide dismutases. Purification, labeling, immunoassay, and tissue concentration. , 1985, The Journal of biological chemistry.

[111]  I. Fridovich,et al.  Isolation and characterization of a manganese-containing superoxide dismutase from yeast. , 1975, The Journal of biological chemistry.

[112]  D. Tyler,et al.  Polarographic assay and intracellular distribution of superoxide dismutase in rat liver. , 1975, The Biochemical journal.

[113]  I. Fridovich,et al.  An iron-containing superoxide dismutase from Escherichia coli. , 1973, The Journal of biological chemistry.

[114]  I. Fridovich,et al.  Mitochondrial superoxide simutase. Site of synthesis and intramitochondrial localization. , 1973, The Journal of biological chemistry.

[115]  I. Fridovich,et al.  Superoxide dismutase from escherichia coli B. A new manganese-containing enzyme. , 1970, The Journal of biological chemistry.

[116]  I. Fridovich,et al.  Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). , 1969, The Journal of biological chemistry.

[117]  M. L’Abbé,et al.  Copper deficiency induces the upregulation of the copper chaperone for Cu/Zn superoxide dismutase in weanling male rats. , 2003, The Journal of nutrition.

[118]  D. Huffman,et al.  Function, structure, and mechanism of intracellular copper trafficking proteins. , 2001, Annual review of biochemistry.

[119]  Jörg Lindenau,et al.  Cellular distribution of superoxide dismutases in the rat CNS , 2000, Glia.

[120]  I. Bertini,et al.  Structure and Properties of Copper-Zinc Superoxide Dismutases , 1998 .