In vivo quantification of the [11C]DASB binding in the normal canine brain using positron emission tomography

[1]  I. Goethals,et al.  Improved HPLC purification strategy for [11C]raclopride and [11C]DASB leading to high radiochemical yields and more practical high quality radiopharmaceutical formulations. , 2013, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[2]  K. Audenaert,et al.  Serotonin 2A receptor, serotonin transporter and dopamine transporter alterations in dogs with compulsive behaviour as a promising model for human obsessive-compulsive disorder , 2012, Psychiatry Research: Neuroimaging.

[3]  Lula Rosso,et al.  Quantification of Ligand PET Studies using a Reference Region with a Displaceable Fraction: Application to Occupancy Studies with [11C]-DASB as an Example , 2012, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[4]  K. Audenaert,et al.  Neuro-imaging the serotonin 2A receptor as a valid biomarker for canine behavioural disorders. , 2011, Research in veterinary science.

[5]  Rupert Lanzenberger,et al.  Serotonin and molecular neuroimaging in humans using PET , 2011, Amino Acids.

[6]  Fumitoshi Kodaka,et al.  Serotonergic neurotransmission in the living human brain: A positron emission tomography study using [11C]dasb and [11C]WAY100635 in young healthy men , 2011, Synapse.

[7]  Chihiro Yokoyama,et al.  Mapping of serotonin transporters by positron emission tomography with [11c]DASB in conscious common marmosets: Comparison with rhesus monkeys , 2010, Synapse.

[8]  Victor W Pike,et al.  PET radiotracers: crossing the blood-brain barrier and surviving metabolism. , 2009, Trends in pharmacological sciences.

[9]  K. Audenaert,et al.  Regional Cerebral Blood Flow Changes in Dogs with Anxiety Disorders, Measured with SPECT , 2009, Brain Imaging and Behavior.

[10]  L. Shuster,et al.  The combined effects of memantine and fluoxetine on an animal model of obsessive compulsive disorder. , 2009, Experimental and clinical psychopharmacology.

[11]  K. Audenaert,et al.  Evaluation of the Brain 5-HT2A Receptor Binding Index in Dogs with Anxiety Disorders, Measured with 123I-5I-R91150 and SPECT , 2009, Journal of Nuclear Medicine.

[12]  R. P. Maguire,et al.  Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[13]  R. Parsey,et al.  Erratum: In vivo quantification of serotonin transporters using [ 11C]DASB and positron emission tomography in humans: Modeling considerations (Journal of Cerebral Blood Flow and Metabolism (2007) 27, (205-217) DOI: 10.1038/sj.jcbfm.9600329) , 2007 .

[14]  Jeffrey H Meyer,et al.  Imaging the serotonin transporter during major depressive disorder and antidepressant treatment. , 2007, Journal of psychiatry & neuroscience : JPN.

[15]  R Todd Ogden,et al.  In vivo Quantification of Serotonin Transporters Using [11C]DASB and Positron Emission Tomography in Humans: Modeling Considerations , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[16]  Yuichi Kimura,et al.  PET kinetic analysis—compartmental model , 2006, Annals of nuclear medicine.

[17]  J. Votaw,et al.  Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. , 2006, Journal of medicinal chemistry.

[18]  K. Audenaert,et al.  Serotonin transporter and dopamine transporter imaging in the canine brain. , 2006, Nuclear medicine and biology.

[19]  Mark Slifstein,et al.  Estimation of serotonin transporter parameters with 11C-DASB in healthy humans: reproducibility and comparison of methods. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[20]  Sylvain Houle,et al.  Regional distribution of serotonin transporter protein in postmortem human brain: is the cerebellum a SERT-free brain region? , 2005, Nuclear medicine and biology.

[21]  Sylvain Houle,et al.  Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes. , 2004, Archives of general psychiatry.

[22]  U. Müller,et al.  Advances in in vivo imaging of serotonergic neurons in neuropsychiatric disorders , 2004, Neuroscience & Biobehavioral Reviews.

[23]  Jeih-San Liow,et al.  Linearized Reference Tissue Parametric Imaging Methods: Application to [11C]DASB Positron Emission Tomography Studies of the Serotonin Transporter in Human Brain , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[24]  Alan A. Wilson,et al.  [11C]‐NS 4194 versus [11C]‐DASB for PET imaging of serotonin transporters in living porcine brain , 2003, Synapse.

[25]  G. Slegers,et al.  Estimates of regional cerebral blood flow and 5-HT2A receptor density in impulsive, aggressive dogs with 99mTc-ECD and 123I-5-I-R91150 , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[26]  G. Slegers,et al.  Regional binding index of the radiolabeled selective 5-HT2A antagonist 123I-5-I-R91150 in the normal canine brain imaged with single photon emission computed tomography. , 2003, Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association.

[27]  Sylvain Houle,et al.  [11C]‐DASB, a tool for in vivo measurement of SSRI‐induced occupancy of the serotonin transporter: PET characterization and evaluation in cats , 2003, Synapse.

[28]  G. Slegers,et al.  Effects of aging on brain perfusion and serotonin-2A receptor binding in the normal canine brain measured with single photon emission tomography , 2002, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[29]  K. Overall,et al.  Clinical features and outcome in dogs and cats with obsessive-compulsive disorder: 126 cases (1989-2000). , 2002, Journal of the American Veterinary Medical Association.

[30]  G. Slegers,et al.  Biodistribution and displacement studies of the selective 5-HT2Areceptor antagonist 123I-5-I-R91150 in the normal dog , 2002, Nuclear medicine communications.

[31]  Sylvain Houle,et al.  In vitro and in vivo characterisation of [11C]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography. , 2002, Nuclear medicine and biology.

[32]  Alan A. Wilson,et al.  Positron Emission Tomography Quantification of [11C]-DASB Binding to the Human Serotonin Transporter: Modeling Strategies , 2001, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[33]  S. Horschitz,et al.  Structure, function and regulation of the 5-hydroxytryptamine (serotonin) transporter. , 2001, Biochemical Society transactions.

[34]  Alan A. Wilson,et al.  Imaging the serotonin transporter with positron emission tomography: initial human studies with [11C]DAPP and [11C]DASB , 2000, European Journal of Nuclear Medicine.

[35]  K. Overall.  Natural animal models of human psychiatric conditions: assessment of mechanism and validity , 2000, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[36]  A. Lammertsma,et al.  Simplified Reference Tissue Model for PET Receptor Studies , 1996, NeuroImage.

[37]  W. Rand,et al.  Use of fluoxetine to treat dominance aggression in dogs. , 1996, Journal of the American Veterinary Medical Association.

[38]  N. Volkow,et al.  Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[39]  David J. Schlyer,et al.  Graphical Analysis of Reversible Radioligand Binding from Time—Activity Measurements Applied to [N-11C-Methyl]-(−)-Cocaine PET Studies in Human Subjects , 1990, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[40]  Marc Laruelle,et al.  Regional and subcellular localization in human brain of [3H]paroxetine binding, a marker of serotonin uptake sites , 1988, Biological Psychiatry.

[41]  I. Goethals,et al.  Evaluation of the PET-radioligand 11C DASB in dogs , 2014 .

[42]  J. Votaw,et al.  Synthesis, radiosynthesis, and biological evaluation of fluorine-18-labeled 2beta-carbo(fluoroalkoxy)-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. , 2008, Journal of medicinal chemistry.

[43]  S. Houle,et al.  Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines. , 2000, Journal of medicinal chemistry.

[44]  R. K. Lim,et al.  A Stereotaxic atlas of the dog`s brain , 1960 .