Hyperpolarized helium‐3 magnetic resonance imaging of chronic obstructive pulmonary disease exacerbation

A chronic obstructive pulmonary disease (COPD) exsmoker underwent pulmonary function tests and hyperpolarized helium‐3 (3He) magnetic resonance imaging (MRI) serially over 4 years, twice prior to and twice following an acute exacerbation (AE). About 2.5 years pre‐AE, 3He ventilation defect percent (VDP) was 16%, the apparent diffusion coefficient (ADC) was 0.34 cm2/s, and forced expiratory volume in 1 sec (FEV1) was 41%pred. Six months pre‐AE, VDP and ADC were worse (29% and 0.38 cm2/s, respectively) without worsening FEV1 (47%pred). After hospitalization and AE treatment, VDP was 20%, whereas FEV1 did not improve (45%pred); 16 months post‐AE, both VDP and ADC remained improved and similar to 4 years prior. J. Magn. Reson. Imaging 2013;37:1223–1227. © 2012 Wiley Periodicals, Inc.

[1]  T. Seemungal,et al.  Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease , 2002, Thorax.

[2]  Jonathan D. Campbell,et al.  Computed tomography correlates with pulmonary exacerbations in children with cystic fibrosis. , 2005, American journal of respiratory and critical care medicine.

[3]  Miranda Kirby,et al.  Chronic obstructive pulmonary disease: longitudinal hyperpolarized (3)He MR imaging. , 2010, Radiology.

[4]  P. Leander,et al.  Validity of apparent diffusion coefficient hyperpolarized 3He-MRI using MSCT and pulmonary function tests as references. , 2009, European journal of radiology.

[5]  F. Martinez,et al.  Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. , 2007, American journal of respiratory and critical care medicine.

[6]  Dmitriy A Yablonskiy,et al.  Hyperpolarized 3He diffusion MRI and histology in pulmonary emphysema , 2006, Magnetic resonance in medicine.

[7]  Per Wollmer,et al.  Hyperpolarized 3He apparent diffusion coefficient MRI of the lung: Reproducibility and volume dependency in healthy volunteers and patients with emphysema , 2008, Journal of magnetic resonance imaging : JMRI.

[8]  P. Reix,et al.  Hyperpolarized 3He MR for sensitive imaging of ventilation function and treatment efficiency in young cystic fibrosis patients with normal lung function. , 2010, Radiology.

[9]  G. Parraga,et al.  Hyperpolarized 3He functional magnetic resonance imaging of bronchoscopic airway bypass in chronic obstructive pulmonary disease. , 2012, Canadian respiratory journal.

[10]  Miranda Kirby,et al.  Hyperpolarized 3He magnetic resonance functional imaging semiautomated segmentation. , 2012, Academic radiology.

[11]  T. Seemungal,et al.  Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. , 1998, American journal of respiratory and critical care medicine.

[12]  Miranda Kirby,et al.  Chronic obstructive pulmonary disease: quantification of bronchodilator effects by using hyperpolarized ³He MR imaging. , 2011, Radiology.

[13]  S. Aaron,et al.  Physiological changes during symptom recovery from moderate exacerbations of COPD , 2005, European Respiratory Journal.

[14]  Aaron Fenster,et al.  Hyperpolarized 3He Ventilation Defects and Apparent Diffusion Coefficients in Chronic Obstructive Pulmonary Disease: Preliminary Results at 3.0 Tesla , 2007, Investigative radiology.

[15]  Jörg Schmiedeskamp,et al.  Diffusion‐weighted MRI of the lung with hyperpolarized helium‐3: A study of reproducibility , 2005, Journal of magnetic resonance imaging : JMRI.

[16]  G. Parraga,et al.  Evaluating bronchodilator effects in chronic obstructive pulmonary disease using diffusion-weighted hyperpolarized helium-3 magnetic resonance imaging. , 2012, Journal of applied physiology.

[17]  Grace Parraga,et al.  Anatomical distribution of 3He apparent diffusion coefficients in severe chronic obstructive pulmonary disease , 2007, Journal of magnetic resonance imaging : JMRI.

[18]  W. Happer,et al.  Biological magnetic resonance imaging using laser-polarized 129Xe , 1994, Nature.

[19]  Grace Parraga,et al.  Hyperpolarized 3He magnetic resonance imaging of chronic obstructive pulmonary disease: reproducibility at 3.0 tesla. , 2008, Academic radiology.

[20]  G. Parraga,et al.  Hyperpolarized ³He magnetic resonance imaging: preliminary evaluation of phenotyping potential in chronic obstructive pulmonary disease. , 2011, European journal of radiology.

[21]  John P Mugler,et al.  Emphysema: hyperpolarized helium 3 diffusion MR imaging of the lungs compared with spirometric indexes--initial experience. , 2002, Radiology.