Effect of UV irradiation on type I collagen fibril formation in neutral collagen solutions

Background: Collagens have the well‐known ability to spontaneously self‐associate to form fibrils at physiological temperature and neutral pH in vitro and in vivo. Because solar UV may photochemically alter collagen, the kinetics of fibril formation may be modified. Thus, we have begun a systematic study of the effect of various UV wavebands on fibril formation.

[1]  K. Scharffetter-Kochanek,et al.  Ultraviolet B Wavelength Dependence for the Regulation of Two Major Matrix‐Metalloproteinases and Their Inhibitor TIMP‐1 in Human Dermal Fibroblasts , 1996, Photochemistry and photobiology.

[2]  J. Menter,et al.  PHOTOCHEMISTRY OF TYPE I ACID‐SOLUBLE CALF SKIN COLLAGEN: DEPENDENCE ON EXCITATION WAVELENGTH , 1995, Photochemistry and photobiology.

[3]  F. Grinnell,et al.  Fibroblasts, myofibroblasts, and wound contraction , 1994, The Journal of cell biology.

[4]  L. Nanney,et al.  Localization of mRNAs representing collagenase and TIMP in sections of healing human burn wounds. , 1993, The American journal of pathology.

[5]  S. Craig,et al.  Ultraviolet A irradiation stimulates collagenase production in cultured human fibroblasts. , 1992, The Journal of investigative dermatology.

[6]  M. Pathak,et al.  Skin photosensitizing agents and the role of reactive oxygen species in photoaging. , 1992, Journal of photochemistry and photobiology. B, Biology.

[7]  T. Hayashi,et al.  Factors affecting the interactions of collagen molecules as observed by in vitro fibril formation. III. Non-helical regions of the collagen molecules. , 1974, Journal of biochemistry.

[8]  T. Miyata,et al.  Effects of ultraviolet irradiation on native and telopeptide-poor collagen. , 1971, Biochimica et biophysica acta.

[9]  J. Gross,et al.  The heat precipitation of collagen from neutral salt solutions: some rate-regulating factors. , 1958, The Journal of biological chemistry.

[10]  H. Noda,et al.  Uv-Irradiation of Collagen and its Effect on Fibril Reconstitution , 1972 .