Assessing Cholesterol Storage in Live Cells and C. elegans by Stimulated Raman Scattering Imaging of Phenyl-Diyne Cholesterol

[1]  Ji-Xin Cheng,et al.  Label-free quantitative analysis of lipid metabolism in living Caenorhabditis elegans[S] , 2010, Journal of Lipid Research.

[2]  K. Cadigan,et al.  Isolation of Chinese hamster ovary cell lines expressing human acyl- coenzyme A/cholesterol acyltransferase activity , 1989, The Journal of cell biology.

[3]  Kai Simons,et al.  Lipid Rafts As a Membrane-Organizing Principle , 2010, Science.

[4]  Christian Matthäus,et al.  Noninvasive imaging of intracellular lipid metabolism in macrophages by Raman microscopy in combination with stable isotopic labeling. , 2012, Analytical chemistry.

[5]  Thomas Hellerer,et al.  Spectral focusing: High spectral resolution spectroscopy with broad-bandwidth laser pulses , 2004 .

[6]  Dan Fu,et al.  Hyperspectral imaging with stimulated Raman scattering by chirped femtosecond lasers. , 2013, The journal of physical chemistry. B.

[7]  W. Hickey,et al.  A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain Published, JLR Papers in Press, January 1, 2004. DOI 10.1194/jlr.D300032-JLR200 , 2004, Journal of Lipid Research.

[8]  G. Ruvkun,et al.  C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. , 2009, Cell metabolism.

[9]  Tao Chen,et al.  Live-cell stimulated Raman scattering imaging of alkyne-tagged biomolecules. , 2014, Angewandte Chemie.

[10]  Gengfeng Zheng,et al.  Laser-scanning coherent anti-Stokes Raman scattering microscopy and applications to cell biology. , 2002, Biophysical journal.

[11]  Delong Zhang,et al.  Highly Sensitive Vibrational Imaging by Femtosecond Pulse Stimulated Raman Loss. , 2011, The journal of physical chemistry letters.

[12]  A. Scholten,et al.  On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases , 2013, Journal of the American Chemical Society.

[13]  John Paul Pezacki,et al.  Chemical contrast for imaging living systems: molecular vibrations drive CARS microscopy , 2011, Nature chemical biology.

[14]  D. Sage,et al.  Selective Visualization of Fluorescent Sterols in Caenorhabditis elegans by Bleach‐Rate‐Based Image Segmentation , 2010, Traffic.

[15]  A S Verkman,et al.  Pyrene eximer mapping in cultured fibroblasts by ratio imaging and time-resolved microscopy. , 1990, Biochemistry.

[16]  V. Matyash,et al.  Distribution and transport of cholesterol in Caenorhabditis elegans. , 2001, Molecular biology of the cell.

[17]  Lukasz M. Solanko,et al.  Membrane orientation and lateral diffusion of BODIPY-cholesterol as a function of probe structure. , 2013, Biophysical journal.

[18]  Ping-yuan Wang,et al.  OSBP Is a Cholesterol-Regulated Scaffolding Protein in Control of ERK1/2 Activation , 2005, Science.

[19]  Shawn T. Brown,et al.  Advances in methods and algorithms in a modern quantum chemistry program package. , 2006, Physical chemistry chemical physics : PCCP.

[20]  J. Repa,et al.  Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1−/− mouse , 2009, Proceedings of the National Academy of Sciences.

[21]  AC Tose.  Cell , 1993, Cell.

[22]  C. Blaha,et al.  OSBP Is a Cholesterol-Regulated Scaffolding Protein in Control of ERK 1 / 2 Activation , 2022 .

[23]  Catherine C. Y. Chang,et al.  Acyl-coenzyme A:cholesterol acyltransferases. , 2009, American journal of physiology. Endocrinology and metabolism.

[24]  T. Chang,et al.  Acyl-coenzyme A:cholesterol acyltransferase. , 1997, Annual review of biochemistry.

[25]  Ilpo Vattulainen,et al.  BODIPY‐Cholesterol: A New Tool to Visualize Sterol Trafficking in Living Cells and Organisms , 2008, Traffic.

[26]  Y. Yamauchi,et al.  Cholesterol sensing, trafficking, and esterification. , 2006, Annual review of cell and developmental biology.

[27]  Michael O. Hengartner,et al.  Finding function in novel targets: C. elegans as a model organism , 2006, Nature Reviews Drug Discovery.

[28]  F. Maxfield,et al.  Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog. , 1998, Biophysical journal.

[29]  Gary Ruvkun,et al.  Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes , 2003, Nature.

[30]  L. Vaca,et al.  CUP-1 Is a Novel Protein Involved in Dietary Cholesterol Uptake in Caenorhabditis elegans , 2012, PloS one.

[31]  J. Billheimer.  Cholesterol acyltransferase. , 1985, Methods in enzymology.

[32]  K. G. Coleman,et al.  Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. , 1997, Science.

[33]  H. Tissenbaum,et al.  A Comparative Study of Fat Storage Quantitation in Nematode Caenorhabditis elegans Using Label and Label-Free Methods , 2010, PloS one.

[34]  James H. Thomas,et al.  NCR-1 and NCR-2, the C. elegans homologs of the human Niemann-Pick type C1 disease protein, function upstream of DAF-9 in the dauer formation pathways , 2004, Development.

[35]  Elina Ikonen,et al.  Cellular cholesterol trafficking and compartmentalization , 2008, Nature Reviews Molecular Cell Biology.

[36]  Thomas de Quincey.  [C] , 2000, The Works of Thomas De Quincey, Vol. 1: Writings, 1799–1820.

[37]  D. Ory,et al.  Niemann-Pick Type C1 (NPC1) Overexpression Alters Cellular Cholesterol Homeostasis* , 2000, The Journal of Biological Chemistry.

[38]  Joseph L. Goldstein,et al.  Protein Sensors for Membrane Sterols , 2006, Cell.

[39]  Jeff S. Jasper,et al.  27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology , 2013, Science.

[40]  Satoshi Kawata,et al.  Alkyne-tag Raman imaging for visualization of mobile small molecules in live cells. , 2012, Journal of the American Chemical Society.

[41]  J. Goldstein,et al.  Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells , 2009, Proceedings of the National Academy of Sciences.

[42]  Ji-Xin Cheng,et al.  High-speed vibrational imaging and spectral analysis of lipid bodies by compound Raman microscopy. , 2009, The journal of physical chemistry. B.

[43]  G. Gimpl,et al.  Cholesterol Reporter Molecules , 2007, Bioscience reports.

[44]  Kwang S. Kim,et al.  Polyenes vs polyynes: Efficient π-frame for nonlinear optical pathways , 2000 .

[45]  J. R. Arthur,et al.  Filipin recognizes both GM1 and cholesterol in GM1 gangliosidosis mouse brain , 2011, Journal of Lipid Research.

[46]  B. Cravatt,et al.  Proteome-wide Mapping of Cholesterol-Interacting Proteins in Mammalian Cells , 2013, Nature Methods.

[47]  Christoph Thiele,et al.  A novel alkyne cholesterol to trace cellular cholesterol metabolism and localization[S] , 2014, Journal of Lipid Research.

[48]  P. Yeagle.  Cholesterol and the cell membrane. , 1985, Biochimica et biophysica acta.

[49]  P. Beachy,et al.  Cholesterol modification of proteins. , 2000, Biochimica et biophysica acta.

[50]  Alberto Diaspro,et al.  Coherent Raman Scattering Microscopy , 2014 .

[51]  Robert V Farese,et al.  Lipid Droplets Finally Get a Little R-E-S-P-E-C-T , 2009, Cell.

[52]  Ho Yi Mak,et al.  Lipid droplets as fat storage organelles in Caenorhabditis elegans , 2012, Journal of Lipid Research.

[53]  R. Bittman,et al.  Sterol effects and sites of sterol accumulation in Caenorhabditis elegans: developmental requirement for 4alpha-methyl sterols. , 2003, Journal of lipid research.

[54]  Andrew C Box,et al.  Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans , 2010, Proceedings of the National Academy of Sciences.

[55]  X. Xie,et al.  Living Cells as Test Tubes , 2006, Science.

[56]  Ira Tabas,et al.  Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. , 2002, The Journal of clinical investigation.

[57]  M. Patterson,et al.  Progesterone blocks cholesterol translocation from lysosomes. , 1992, The Journal of biological chemistry.

[58]  Satoshi Kawata,et al.  Imaging of EdU, an alkyne-tagged cell proliferation probe, by Raman microscopy. , 2011, Journal of the American Chemical Society.

[59]  Jürgen Popp,et al.  Quantitative detection of C-deuterated drugs by CARS microscopy and Raman microspectroscopy. , 2011, The Analyst.

[60]  Wei Min,et al.  Vibrational imaging of newly synthesized proteins in live cells by stimulated Raman scattering microscopy , 2013, Proceedings of the National Academy of Sciences.

[61]  M. Patterson.  A Riddle Wrapped in a Mystery: Understanding Niemann-Pick Disease, Type C , 2003, The neurologist.

[62]  Ping Wang,et al.  Fast Vibrational Imaging of Single Cells and Tissues by Stimulated Raman Scattering Microscopy , 2014, Accounts of chemical research.

[63]  F. Pfrieger,et al.  Cholesterol homeostasis and function in neurons of the central nervous system , 2003, Cellular and Molecular Life Sciences CMLS.

[64]  Ji-Xin Cheng,et al.  Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness. , 2014, Cell metabolism.

[65]  Lu Wei,et al.  Live-cell imaging of alkyne-tagged small biomolecules by stimulated Raman scattering , 2014, Nature Methods.

[66]  R. Ansell,et al.  Cholesterol oxidase: sources, physical properties and analytical applications , 2000, The Journal of Steroid Biochemistry and Molecular Biology.

[67]  Min Goo Lee,et al.  Cholesterol Modulates Cell Signaling and Protein Networking by Specifically Interacting with PDZ Domain-Containing Scaffold Proteins , 2012, Nature Communications.