Anatomy of the human hypothalamus (chiasmatic and tuberal region).

The hypothalamus sensu stricto consists of the chiasmatic, the tuberal and the mamillary region. The present study is confined to the poorly myelinated chiasmatic and tuberal region. Both regions harbor many nuclear grays with relatively clear-cut boundaries embedded in an ill-defined nerve cell assembly referred to as the hypothalamic gray. Prominent components of the chiasmatic region are the magnocellular neurosecretory complex (supraoptic nucleus, paraventricular nucleus, accessory neurosecretory nucleus), the sexually dimorphic intermediate nucleus, the suprachiasmatic and retrochiasmatic nuclei. The dominating structure of the tuberal region is the complex of the ventromedial, posteromedial and dorsomedial nuclei supplemented by the periventricular and infundibular nuclei. Lateral portions of the tuber cinereum harbor the lateral tuberal nucleus and the tuberomamillary nucleus. The lateral tuberal nucleus exhibits pronounced cell loss in Huntington's chorea and is also severely involved in cases of dementia with argyrophilic grains. The large nerve cells of the tuberomamillary nucleus show particularly severe affection in both Alzheimer's (intraneuronal neurofibrillary changes) and Parkinson's disease (Lewy bodies).

[1]  W. Bargmann.  [The neurosecretory connection between the hypothalamus and the neurohypophysis]. , 1949, Zeitschrift fur Zellforschung und mikroskopische Anatomie.

[2]  H. Braak,et al.  CORTICAL AND SUBCORTICAL ARGYROPHILIC GRAINS CHARACTERIZE A DISEASE ASSOCIATED WITH ADULT ONSET DEMENTIA , 1989, Neuropathology and applied neurobiology.

[3]  R. Moore.  The suprachiasmatic nucleus and the organization of a circadian system , 1982, Trends in Neurosciences.

[4]  D. Reis,et al.  Distribution of catecholamine-containing neurons in the normal human hypothalamus , 1985, Brain Research.

[5]  D. Swaab,et al.  The sexually dimorphic nucleus of the preoptic area in the human brain: a comparative morphometric study. , 1989, Journal of anatomy.

[6]  O. Vogt,et al.  Precipitating and modifying agents in chorea. , 1952, The Journal of nervous and mental disease.

[7]  U. Pirvola,et al.  A histamine-containing neuronal system in human brain , 1990, Neuroscience.

[8]  P. Daniel,et al.  STUDIES OF THE HYPOTHALAMUS AND THE PITUITARY GLAND with special reference to the effects of transection of the pituitary stalk , 1975, Acta endocrinologica. Supplementum.

[9]  T. Batten,et al.  The hypothalamus and pituitary gland , 1986 .

[10]  D. Swaab,et al.  Sexual differentiation of the human hypothalamus: ontogeny of the sexually dimorphic nucleus of the preoptic area. , 1988, Brain research. Developmental brain research.

[11]  D. German,et al.  Hypothalamic pathology in Alzheimer's disease , 1987, Neuroscience Letters.

[12]  H. Braak,et al.  Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques , 1986, Neuroscience Letters.

[13]  E. Masliah,et al.  Late onset dementia with argyrophilic grains and subcortical tangles or atypical progressive supranuclear palsy? , 1991, Annals of neurology.

[14]  R. Lydic,et al.  Human brain contains vasopressin and vasoactive intestinal polypeptide neuronal subpopulations in the suprachiasmatic region , 1984, Brain Research.

[15]  D. German,et al.  Alzheimer's disease: Neurofibrillary tangles in nuclei that project to the cerebral cortex , 1987, Neuroscience.

[16]  G. Fink,et al.  CONGO RED BIREFRINGENT STRUCTURES IN THE HYPOTHALAMUS IN SENILE DEMENTIA OF THE ALZHEIMER TYPE , 1988, Neuropathology and applied neurobiology.

[17]  W. Wahren.  Zur Pathoklise des Nucleus Tuberis Lateralis , 1964 .

[18]  V. Cassone,et al.  Comparative Anatomy of the Mammalian Hypothalamic Suprachiasmatic Nucleus , 1988, Journal of biological rhythms.

[19]  K. Feremutsch.  Die Variabilität der cytoarchitektonischen Struktur des menschlichen Hypothalamus , 1951 .

[20]  B. Bogerts.  A brainstem atlas of catecholaminergic neurons in man, using melanin as a natural marker , 1981, The Journal of comparative neurology.

[21]  Prof. Dr. Heiko Braak,et al.  Architectonics of the Human Telencephalic Cortex , 1980, Studies of Brain Function.

[22]  J W Langston,et al.  The hypothalamus in parkinson disease , 1978, Annals of neurology.

[23]  E Maran,et al.  Atrophy of the Hypothalamic Lateral Tuberal Nucleus in Huntington's Disease , 1990, Journal of neuropathology and experimental neurology.

[24]  B. L. Beattie,et al.  A case of adult‐onset dementia with argyrophilic grains , 1989, Annals of neurology.

[25]  W. Möllendorff,et al.  Handbuch der Mikroskopischen Anatomie des Menschen , 1958 .

[26]  R. Ravid,et al.  The hypothalamic lateral tuberal nucleus in Alzheimer's disease , 1991, Annals of neurology.

[27]  W. Cowan,et al.  Direct hypothalamo-autonomic connections , 1976, Brain Research.

[28]  R. Moore.  The geniculohypothalamic tract in monkey and man , 1989, Brain Research.

[29]  Clark We.  The Topography and Homologies of the Hypothalamic Nuclei in Man. , 1936 .

[30]  C. Saper,et al.  Preservation of hypothalamic dopaminergic neurons in Parkinson's disease , 1985, Annals of neurology.

[31]  Lois E. H. Smith,et al.  A retinohypothalamic pathway in man: Light mediation of circadian rhythms , 1984, Brain Research.

[32]  R. Bleier,et al.  Cytoarchitectonic sexual dimorphisms of the medial preoptic and anterior hypothalamic areas in guinea pig, rat, hamster, and mouse , 1982, The Journal of comparative neurology.

[33]  M. Mirmiran,et al.  Biological clocks in development, aging and Alzheimer's disease , 1989 .

[34]  R. Moore,et al.  Retinohypothalamic projection in mammals: a comparative study. , 1973, Brain research.

[35]  E. G. Jones,et al.  Midbrain, diencephalic and cortical relationships of the basal nucleus of meynert and associated structures in primates , 1976, The Journal of comparative neurology.

[36]  G. Fenichel,et al.  Studies on neuromelanin , 1967, Neurology.

[37]  D F Swaab,et al.  A sexually dimorphic nucleus in the human brain. , 1985, Science.

[38]  H. Kuhlenbeck,et al.  The derivatives of the hypothalamus in the human brain; their relation to the extrapyramidal and autonomic systems. , 1949, Military surgeon.

[39]  L Teckhaus,et al.  Evidence for subdivisions in the human suprachiasmatic nucleus , 1991, The Journal of comparative neurology.

[40]  M. Yahr,et al.  Protein-rich cytoplasmic bodies of substantia nigra and locus ceruleus. A comparative study in parkinsonian and normal brain. , 1978, Archives of neurology.

[41]  E. Zimmerman,et al.  The magnocellular neurosecretory system of the mammalian hypothalamus. , 1978, Research publications - Association for Research in Nervous and Mental Disease.

[42]  Edward A. Malone.  Über die Kerne des Menschlichen Diencephalon , 1910 .

[43]  R. Gorski,et al.  Two sexually dimorphic cell groups in the human brain , 1989, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[44]  D. F. Swaab,et al.  The suprachiasmatic nucleus of the human brain in relation to sex, age and senile dementia , 1985, Brain Research.

[45]  L. Swanson,et al.  The distribution of oxytocin‐ and neurophysin‐stained fibers in the spinal cord of the rat and monkey , 1979, The Journal of comparative neurology.

[46]  E. Fliers,et al.  The supraoptic and paraventricular nuclei of the human hypothalamus in relation to sex, age and Alzheimer's disease , 1990, Neurobiology of Aging.